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Title: Structural basis for selective targeting of leishmanial ribosomes: Aminoglycoside derivatives as promising therapeutics

Abstract

Leishmaniasis comprises an array of diseases caused by pathogenic species of Leishmania, resulting in a spectrum of mild to life-threatening pathologies. Currently available therapies for leishmaniasis include a limited selection of drugs. This coupled with the rather fast emergence of parasite resistance, presents a dire public health concern. Paromomycin (PAR), a broad-spectrum aminoglycoside antibiotic, has been shown in recent years to be highly efficient in treating visceral leishmaniasis (VL)—the life-threatening form of the disease. While much focus has been given to exploration of PAR activities in bacteria, its mechanism of action in Leishmania has received relatively little scrutiny and has yet to be fully deciphered. In the present study we present an X-ray structure of PAR bound to rRNA model mimicking its leishmanial binding target, the ribosomal A-site. We evaluate PAR inhibitory actions on leishmanial growth and ribosome function, as well as effects on auditory sensory cells, by comparing several structurally related natural and synthetic aminoglycoside derivatives. The results provide insights into the structural elements important for aminoglycoside inhibitory activities and selectivity for leishmanial cytosolic ribosomes, highlighting a novel synthetic derivative, compound 3, as a prospective therapeutic candidate for the treatment of VL.

Authors:
 [1];  [2];  [3];  [4];  [4];  [3];  [5];  [5];  [4];  [3];  [3]
+ Show Author Affiliations
  1. Israel Institute of Technology, Haifa (Israel); Weizmann Institute of Science, Rehovot (Israel)
  2. Weizmann Institute of Science, Rehovot (Israel)
  3. Israel Institute of Technology, Haifa (Israel)
  4. Hebrew Univ.-Hadassah Medical School, Jerusalem (Israel)
  5. Univ. of Michigan Medical School, Ann Arbor, MI (United States)
Publication Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1223387
Grant/Contract Number:  
AC02-06CH11357
Resource Type:
Accepted Manuscript
Journal Name:
Nucleic Acids Research
Additional Journal Information:
Journal Volume: 43; Journal Issue: 17; Journal ID: ISSN 0305-1048
Publisher:
Oxford University Press
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Shalev, Moran, Rozenberg, Haim, Smolkin, Boris, Nasereddin, Abedelmajeed, Kopelyanskiy, Dmitry, Belakhov, Valery, Schrepfer, Thomas, Schacht, Jochen, Jaffe, Charles L., Adir, Noam, and Baasov, Timor. Structural basis for selective targeting of leishmanial ribosomes: Aminoglycoside derivatives as promising therapeutics. United States: N. p., 2015. Web. doi:10.1093/nar/gkv821.
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Shalev, Moran, Rozenberg, Haim, Smolkin, Boris, Nasereddin, Abedelmajeed, Kopelyanskiy, Dmitry, Belakhov, Valery, Schrepfer, Thomas, Schacht, Jochen, Jaffe, Charles L., Adir, Noam, & Baasov, Timor. Structural basis for selective targeting of leishmanial ribosomes: Aminoglycoside derivatives as promising therapeutics. United States. https://doi.org/10.1093/nar/gkv821
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Shalev, Moran, Rozenberg, Haim, Smolkin, Boris, Nasereddin, Abedelmajeed, Kopelyanskiy, Dmitry, Belakhov, Valery, Schrepfer, Thomas, Schacht, Jochen, Jaffe, Charles L., Adir, Noam, and Baasov, Timor. Tue . "Structural basis for selective targeting of leishmanial ribosomes: Aminoglycoside derivatives as promising therapeutics". United States. https://doi.org/10.1093/nar/gkv821. https://www.osti.gov/servlets/purl/1223387.
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@article{osti_1223387,
title = {Structural basis for selective targeting of leishmanial ribosomes: Aminoglycoside derivatives as promising therapeutics},
author = {Shalev, Moran and Rozenberg, Haim and Smolkin, Boris and Nasereddin, Abedelmajeed and Kopelyanskiy, Dmitry and Belakhov, Valery and Schrepfer, Thomas and Schacht, Jochen and Jaffe, Charles L. and Adir, Noam and Baasov, Timor},
abstractNote = {Leishmaniasis comprises an array of diseases caused by pathogenic species of Leishmania, resulting in a spectrum of mild to life-threatening pathologies. Currently available therapies for leishmaniasis include a limited selection of drugs. This coupled with the rather fast emergence of parasite resistance, presents a dire public health concern. Paromomycin (PAR), a broad-spectrum aminoglycoside antibiotic, has been shown in recent years to be highly efficient in treating visceral leishmaniasis (VL)—the life-threatening form of the disease. While much focus has been given to exploration of PAR activities in bacteria, its mechanism of action in Leishmania has received relatively little scrutiny and has yet to be fully deciphered. In the present study we present an X-ray structure of PAR bound to rRNA model mimicking its leishmanial binding target, the ribosomal A-site. We evaluate PAR inhibitory actions on leishmanial growth and ribosome function, as well as effects on auditory sensory cells, by comparing several structurally related natural and synthetic aminoglycoside derivatives. The results provide insights into the structural elements important for aminoglycoside inhibitory activities and selectivity for leishmanial cytosolic ribosomes, highlighting a novel synthetic derivative, compound 3, as a prospective therapeutic candidate for the treatment of VL.},
doi = {10.1093/nar/gkv821},
journal = {Nucleic Acids Research},
number = 17,
volume = 43,
place = {United States},
year = {Tue Aug 11 00:00:00 EDT 2015},
month = {Tue Aug 11 00:00:00 EDT 2015}
}
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https://doi.org/10.1093/nar/gkv821
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The bacterial and mitochondrial ribosomal A-site molecular switches possess different conformational substates
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journal, April 2013

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text, January 2010

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