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Title: Hybrid nanotrimers for dual T1 and T2-weighted magnetic resonance imaging

Development of multifunctional nanoparticle-based probes for dual T1- and T2-weighted magnetic resonance imaging (MRI) could allow us to image and diagnose the tumors or other abnormalities in an exceptionally accurate and reliable manner. In this study, by fusing distinct nanocrystals via solid-state interfaces, we built hybrid heteronanostructures to combine both T1 and T2- weighted contrast agents together for MRI with high accuracy and reliability. The resultant hybrid heterotrimers showed high stability in physiological conditions and could induce both simultaneous positive and negative contrast enhancements in MR images. Small animal positron emission tomography imaging study revealed that the hybrid heterostructures displayed favorable biodistribution and were suitable for in vivo imaging. Furthermore, their potential as dual contrast agents for T1 and T2-weighted MRI was further demonstrated by in vitro and in vivo imaging and relaxivity measurements.
Authors:
 [1] ;  [1] ;  [2] ;  [1] ;  [1] ;  [1]
  1. Stanford Univ., Stanford, CA (United States)
  2. Stanford Univ., Stanford, CA (United States); First Hospital of Shanxi Medical Univ., Shanxi (China)
Publication Date:
Grant/Contract Number:
SC0008397
Type:
Published Article
Journal Name:
ACS Nano
Additional Journal Information:
Journal Volume: 8; Journal Issue: 10; Journal ID: ISSN 1936-0851
Publisher:
American Chemical Society (ACS)
Research Org:
Stanford Univ., CA (United States)
Sponsoring Org:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23)
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE; 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; dumbbell structures; hybrid; nanotrimers; positron emission tomography; T1/T2-weighted magnetic resonance imaging
OSTI Identifier:
1222731
Alternate Identifier(s):
OSTI ID: 1346921