Hybrid Nanotrimers for Dual T 1 and T 2 -Weighted Magnetic Resonance Imaging

Cheng, Kai; Yang, Meng; Zhang, Ruiping; Qin, Chunxia; Su, Xinhui; Cheng, Zhen

doi:10.1021/nn500188y

Title: Hybrid Nanotrimers for Dual T ₁ and T ₂ -Weighted Magnetic Resonance Imaging

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Abstract

Development of multifunctional nanoparticle-based probes for dual T₁- and T₂-weighted magnetic resonance imaging (MRI) could allow us to image and diagnose the tumors or other abnormalities in an exceptionally accurate and reliable manner. In this study, by fusing distinct nanocrystals via solid-state interfaces, we built hybrid heteronanostructures to combine both T₁ and T₂- weighted contrast agents together for MRI with high accuracy and reliability. The resultant hybrid heterotrimers showed high stability in physiological conditions and could induce both simultaneous positive and negative contrast enhancements in MR images. Small animal positron emission tomography imaging study revealed that the hybrid heterostructures displayed favorable biodistribution and were suitable for in vivo imaging. Furthermore, their potential as dual contrast agents for T₁ and T₂-weighted MRI was further demonstrated by in vitro and in vivo imaging and relaxivity measurements.

Authors:

Cheng, Kai ^[1]; Yang, Meng ^[1]; Zhang, Ruiping ^[2]; Qin, Chunxia ^[1]; Su, Xinhui ^[1]; Cheng, Zhen ^[1]

Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Road, Lucas P095, Stanford, California 94305-5484, United States
Molecular Imaging Program at Stanford (MIPS), Canary Center at Stanford for Cancer Early Detection, Department of Radiology and Bio-X Program, School of Medicine, Stanford University, 1201 Welch Road, Lucas P095, Stanford, California 94305-5484, United States, Department of Radiology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China

Publication Date:: Wed Oct 08 00:00:00 EDT 2014

Research Org.:: Stanford Univ., CA (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

OSTI Identifier:: 1222731

Alternate Identifier(s):: OSTI ID: 1346921

Grant/Contract Number:: SC0008397

Resource Type:: Published Article

Journal Name:: ACS Nano

Additional Journal Information:: Journal Name: ACS Nano Journal Volume: 8 Journal Issue: 10; Journal ID: ISSN 1936-0851

Publisher:: American Chemical Society

Country of Publication:: United States

Language:: English

Subject:: 36 MATERIALS SCIENCE; 46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY; dumbbell structures; hybrid; nanotrimers; positron emission tomography; T1/T2-weighted magnetic resonance imaging

Citation Formats


                    Cheng, Kai, Yang, Meng, Zhang, Ruiping, Qin, Chunxia, Su, Xinhui, and Cheng, Zhen. Hybrid Nanotrimers for Dual T 1 and T 2 -Weighted Magnetic Resonance Imaging.  United States: N. p., 2014. 
Web.  doi:10.1021/nn500188y.

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                    Cheng, Kai, Yang, Meng, Zhang, Ruiping, Qin, Chunxia, Su, Xinhui, & Cheng, Zhen. Hybrid Nanotrimers for Dual T 1 and T 2 -Weighted Magnetic Resonance Imaging.  United States.  https://doi.org/10.1021/nn500188y

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                    Cheng, Kai, Yang, Meng, Zhang, Ruiping, Qin, Chunxia, Su, Xinhui, and Cheng, Zhen. Wed .  
"Hybrid Nanotrimers for Dual T 1 and T 2 -Weighted Magnetic Resonance Imaging".  United States.  https://doi.org/10.1021/nn500188y.

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@article{osti_1222731,

  title        = {Hybrid Nanotrimers for Dual T 1 and T 2 -Weighted Magnetic Resonance Imaging},

  author       = {Cheng, Kai and Yang, Meng and Zhang, Ruiping and Qin, Chunxia and Su, Xinhui and Cheng, Zhen},

  abstractNote = {Development of multifunctional nanoparticle-based probes for dual T1- and T2-weighted magnetic resonance imaging (MRI) could allow us to image and diagnose the tumors or other abnormalities in an exceptionally accurate and reliable manner. In this study, by fusing distinct nanocrystals via solid-state interfaces, we built hybrid heteronanostructures to combine both T1 and T2- weighted contrast agents together for MRI with high accuracy and reliability. The resultant hybrid heterotrimers showed high stability in physiological conditions and could induce both simultaneous positive and negative contrast enhancements in MR images. Small animal positron emission tomography imaging study revealed that the hybrid heterostructures displayed favorable biodistribution and were suitable for in vivo imaging. Furthermore, their potential as dual contrast agents for T1 and T2-weighted MRI was further demonstrated by in vitro and in vivo imaging and relaxivity measurements.},

  doi          = {10.1021/nn500188y},

  journal      = {ACS Nano},

  number       = 10,

  volume       = 8,

  place        = {United States},

  year         = {Wed Oct 08 00:00:00 EDT 2014},

  month        = {Wed Oct 08 00:00:00 EDT 2014}

}

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Title: Hybrid Nanotrimers for Dual T 1 and T 2 -Weighted Magnetic Resonance Imaging

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Title: Hybrid Nanotrimers for Dual T ₁ and T ₂ -Weighted Magnetic Resonance Imaging