Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model
Abstract
Clostridia are anaerobic Gram-positive Firmicutes containing broad and flexible systems for substrate utilization, which have been used successfully to produce a range of industrial compounds. In particular, Clostridium acetobutylicum has been used to produce butanol on an industrial scale through acetone-butanol-ethanol (ABE) fermentation. A genome-scale metabolic (GSM) model is a powerful tool for understanding the metabolic capacities of an organism and developing metabolic engineering strategies for strain development. The integration of stress-related specific transcriptomics information with the GSM model provides opportunities for elucidating the focal points of regulation.
- Authors:
-
- Pennsylvania State Univ., University Park, PA (United States)
- Delaware Biotechnology Institute, Newark, DE (United States); Univ. of Delaware, Newark, DE (United States)
- Publication Date:
- Research Org.:
- Pennsylvania State Univ., University Park, PA (United States); Univ. of Delaware, Newark, DE (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1221631
- Alternate Identifier(s):
- OSTI ID: 1454689
- Grant/Contract Number:
- SC0007092; sc0007092
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Biotechnology for Biofuels
- Additional Journal Information:
- Journal Volume: 7; Journal Issue: 1; Journal ID: ISSN 1754-6834
- Publisher:
- BioMed Central
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; Clostridium acetobutylicum; CoreReg; regulation; genome-scale metabolic model
Citation Formats
Dash, Satyakam, Mueller, Thomas J., Venkataramanan, Keerthi P., Papoutsakis, Eleftherios T., and Maranas, Costas D. Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model. United States: N. p., 2014.
Web. doi:10.1186/s13068-014-0144-4.
Dash, Satyakam, Mueller, Thomas J., Venkataramanan, Keerthi P., Papoutsakis, Eleftherios T., & Maranas, Costas D. Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model. United States. https://doi.org/10.1186/s13068-014-0144-4
Dash, Satyakam, Mueller, Thomas J., Venkataramanan, Keerthi P., Papoutsakis, Eleftherios T., and Maranas, Costas D. Tue .
"Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model". United States. https://doi.org/10.1186/s13068-014-0144-4. https://www.osti.gov/servlets/purl/1221631.
@article{osti_1221631,
title = {Capturing the response of Clostridium acetobutylicum to chemical stressors using a regulated genome-scale metabolic model},
author = {Dash, Satyakam and Mueller, Thomas J. and Venkataramanan, Keerthi P. and Papoutsakis, Eleftherios T. and Maranas, Costas D.},
abstractNote = {Clostridia are anaerobic Gram-positive Firmicutes containing broad and flexible systems for substrate utilization, which have been used successfully to produce a range of industrial compounds. In particular, Clostridium acetobutylicum has been used to produce butanol on an industrial scale through acetone-butanol-ethanol (ABE) fermentation. A genome-scale metabolic (GSM) model is a powerful tool for understanding the metabolic capacities of an organism and developing metabolic engineering strategies for strain development. The integration of stress-related specific transcriptomics information with the GSM model provides opportunities for elucidating the focal points of regulation.},
doi = {10.1186/s13068-014-0144-4},
journal = {Biotechnology for Biofuels},
number = 1,
volume = 7,
place = {United States},
year = {Tue Oct 14 00:00:00 EDT 2014},
month = {Tue Oct 14 00:00:00 EDT 2014}
}
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