Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants

Berni Canani, Roberto; Sangwan, Naseer; Stefka, Andrew T.; Nocerino, Rita; Paparo, Lorella; Aitoro, Rosita; Calignano, Antonio; Khan, Aly A.; Gilbert, Jack A.; Nagler, Cathryn R.

doi:10.1038/ismej.2015.151

Title: Lactobacillus rhamnosus GG-supplemented formula expands butyrate-producing bacterial strains in food allergic infants

Journal Article · 22 September 2015 · The ISME Journal

DOI: https://doi.org/10.1038/ismej.2015.151 · OSTI ID:1218958

Berni Canani, Roberto ^[1]; Sangwan, Naseer ^[2]; Stefka, Andrew T. ^[3]; Nocerino, Rita ^[1]; Paparo, Lorella ^[1]; Aitoro, Rosita ^[1]; Calignano, Antonio ^[1]; Khan, Aly A. ^[4]; Gilbert, Jack A. ^[5]; Nagler, Cathryn R. ^[3]

Univ. of Naples Federico II, Naples (Italy)
Argonne National Lab. (ANL), Argonne, IL (United States)
Univ. of Chicago, Chicago, IL (United States)
Toyota Technological Inst. at Chicago, Chicago, IL (United States)
Argonne National Lab. (ANL), Argonne, IL (United States); Univ. of Chicago, Chicago, IL (United States)

Dietary intervention with extensively hydrolyzed casein formula supplemented with Lactobacillus rhamnosus GG (EHCF+LGG) accelerates tolerance acquisition in infants with cow’s milk allergy (CMA). We examined whether this effect is attributable, at least in part, to an influence on the gut microbiota. Fecal samples from healthy controls (n=20) and from CMA infants (n=19) before and after treatment with EHCF with (n=12) and without (n=7) supplementation with LGG were compared by 16S rRNA-based operational taxonomic unit clustering and oligotyping. Differential feature selection and generalized linear model fitting revealed that the CMA infants have a diverse gut microbial community structure dominated by Lachnospiraceae (20.5±9.7%) and Ruminococcaceae (16.2±9.1%). Blautia, Roseburia and Coprococcus were significantly enriched following treatment with EHCF and LGG, but only one genus, Oscillospira, was significantly different between infants that became tolerant and those that remained allergic. However, most tolerant infants showed a significant increase in fecal butyrate levels, and those taxa that were significantly enriched in these samples, Blautia and Roseburia, exhibited specific strain-level demarcations between tolerant and allergic infants. As a result, our data suggest that EHCF+LGG promotes tolerance in infants with CMA, in part, by influencing the strain-level bacterial community structure of the infant gut.

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Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 1218958

Journal Information:: The ISME Journal, Journal Name: The ISME Journal; ISSN 1751-7362

Publisher:: Nature Publishing GroupCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 314 works

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The therapeutic efficacy of Bifidobacterium animalis subsp. lactis BB-12 ® in infant colic: A randomised, double blind, placebo-controlled trial Nocerino, Rita; De Filippis, Francesca; Cecere, Gaetano Alimentary Pharmacology & Therapeutics, Vol. 51, Issue 1 https://doi.org/10.1111/apt.15561	journal	December 2019
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Lactobacillus rhamnosus GG Affects Microbiota and Suppresses Autophagy in the Intestines of Pigs Challenged with Salmonella Infantis Zhang, Wei; Zhu, Yao-Hong; Yang, Gui-Yan Frontiers in Microbiology, Vol. 8 https://doi.org/10.3389/fmicb.2017.02705	journal	January 2018
Fine Resolution Analysis of Microbial Communities Provides Insights Into the Variability of Cocoa Bean Fermentation Pacheco-Montealegre, Mauricio Edilberto; Dávila-Mora, Lizeth Lorena; Botero-Rute, Lina Marcela Frontiers in Microbiology, Vol. 11 https://doi.org/10.3389/fmicb.2020.00650	journal	April 2020
Lactobacillus reuteri I5007 Modulates Intestinal Host Defense Peptide Expression in the Model of IPEC-J2 Cells and Neonatal Piglets Liu, Hongbin; Hou, Chengli; Wang, Gang Nutrients, Vol. 9, Issue 6 https://doi.org/10.3390/nu9060559	journal	May 2017
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Probiotics and Prebiotics in Infant Formulae Maldonado, José Prebiotics and Probiotics - Potential Benefits in Nutrition and Health https://doi.org/10.5772/intechopen.88609	book	March 2020

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