Cell fate regulation governed by a repurposed bacterial histidine kinase
Abstract
One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interaction between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.
- Authors:
-
- Stanford Univ. School of Medicine, Stanford, CA (United States)
- SLAC National Accelerator Laboratory, Menlo Park, CA (United States)
- Rutgers Univ., New Brunswick, NJ (United States)
- Publication Date:
- Research Org.:
- SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
- Sponsoring Org.:
- USDOE Office of Science (SC)
- OSTI Identifier:
- 1213908
- Grant/Contract Number:
- AC03-76SF00515
- Resource Type:
- Accepted Manuscript
- Journal Name:
- PLoS Biology (Online)
- Additional Journal Information:
- Journal Name: PLoS Biology (Online); Journal Volume: 12; Journal Issue: 10; Journal ID: ISSN 1545-7885
- Publisher:
- Public Library of Science
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES; phosphorylation; xylose; binding analysis; cell cycle and cell division; point mutation; crystal structure; caulobacter; histidine
Citation Formats
Childers, W. Seth, Xu, Qingping, Mann, Thomas H., Mathews, Irimpan I., Blair, Jimmy A., Deacon, Ashley M., Shapiro, Lucy, and Stock, Ann M. Cell fate regulation governed by a repurposed bacterial histidine kinase. United States: N. p., 2014.
Web. doi:10.1371/journal.pbio.1001979.
Childers, W. Seth, Xu, Qingping, Mann, Thomas H., Mathews, Irimpan I., Blair, Jimmy A., Deacon, Ashley M., Shapiro, Lucy, & Stock, Ann M. Cell fate regulation governed by a repurposed bacterial histidine kinase. United States. https://doi.org/10.1371/journal.pbio.1001979
Childers, W. Seth, Xu, Qingping, Mann, Thomas H., Mathews, Irimpan I., Blair, Jimmy A., Deacon, Ashley M., Shapiro, Lucy, and Stock, Ann M. Tue .
"Cell fate regulation governed by a repurposed bacterial histidine kinase". United States. https://doi.org/10.1371/journal.pbio.1001979. https://www.osti.gov/servlets/purl/1213908.
@article{osti_1213908,
title = {Cell fate regulation governed by a repurposed bacterial histidine kinase},
author = {Childers, W. Seth and Xu, Qingping and Mann, Thomas H. and Mathews, Irimpan I. and Blair, Jimmy A. and Deacon, Ashley M. and Shapiro, Lucy and Stock, Ann M.},
abstractNote = {One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via an interaction with the response regulator (RR) DivK. DivL uniquely contains a tyrosine at the histidine phosphorylation site, and can achieve these regulatory functions in vivo without kinase activity. Determination of the DivL crystal structure and biochemical analysis of wild-type and site-specific DivL mutants revealed that the DivL PAS domains regulate binding specificity for DivK~P over DivK, which is modulated by an allosteric intramolecular interaction between adjacent domains. We discovered that DivL's catalytic domains have been repurposed as a phosphospecific RR input sensor, thereby reversing the flow of information observed in conventional histidine kinase (HK)-RR systems and coupling a complex network of signaling proteins for cell-fate regulation.},
doi = {10.1371/journal.pbio.1001979},
journal = {PLoS Biology (Online)},
number = 10,
volume = 12,
place = {United States},
year = {Tue Oct 28 00:00:00 EDT 2014},
month = {Tue Oct 28 00:00:00 EDT 2014}
}
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Works referenced in this record:
Assembly of the Caulobacter cell division machine: Divisome assembly in Caulobacter
journal, May 2011
- Goley, Erin D.; Yeh, Yi-Chun; Hong, Sun-Hae
- Molecular Microbiology, Vol. 80, Issue 6
Distinct Constrictive Processes, Separated in Time and Space, Divide Caulobacter Inner and Outer Membranes
journal, October 2005
- Judd, Ellen M.; Comolli, Luis R.; Chen, Joseph C.
- Journal of Bacteriology, Vol. 187, Issue 20
Fluorescence bleaching reveals asymmetric compartment formation prior to cell division in Caulobacter
journal, June 2003
- Judd, Ellen M.; Ryan, Kathleen R.; Moerner, W. E.
- Proceedings of the National Academy of Sciences, Vol. 100, Issue 14
Differential Localization of Two Histidine Kinases Controlling Bacterial Cell Differentiation
journal, November 1999
- Wheeler, Robert T.; Shapiro, Lucy
- Molecular Cell, Vol. 4, Issue 5
Recruitment of a cytoplasmic response regulator to the cell pole is linked to its cell cycle-regulated proteolysis
journal, April 2004
- Ryan, K. R.; Huntwork, S.; Shapiro, L.
- Proceedings of the National Academy of Sciences, Vol. 101, Issue 19
Genes directly controlled by CtrA, a master regulator of the Caulobacter cell cycle
journal, April 2002
- Laub, M. T.; Chen, S. L.; Shapiro, L.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 7
Interplay between the Localization and Kinetics of Phosphorylation in Flagellar Pole Development of the Bacterium Caulobacter crescentus
journal, August 2012
- Tropini, Carolina; Huang, Kerwyn Casey
- PLoS Computational Biology, Vol. 8, Issue 8
Allosteric Regulation of Histidine Kinases by Their Cognate Response Regulator Determines Cell Fate
journal, May 2008
- Paul, Ralf; Jaeger, Tina; Abel, Sören
- Cell, Vol. 133, Issue 3
The Asymmetric Spatial Distribution of Bacterial Signal Transduction Proteins Coordinates Cell Cycle Events
journal, July 2003
- Lam, Hubert; Matroule, Jean-Yves; Jacobs-Wagner, Christine
- Developmental Cell, Vol. 5, Issue 1
Dynamic localization of a cytoplasmic signal transduction response regulator controls morphogenesis during the Caulobacter cell cycle
journal, March 2001
- Jacobs, C.; Hung, D.; Shapiro, L.
- Proceedings of the National Academy of Sciences, Vol. 98, Issue 7
DivL Performs Critical Cell Cycle Functions in Caulobacter crescentus Independent of Kinase Activity
journal, September 2007
- Reisinger, Sarah J.; Huntwork, Sarah; Viollier, Patrick H.
- Journal of Bacteriology, Vol. 189, Issue 22
A Dynamic Complex of Signaling Proteins Uses Polar Localization to Regulate Cell-Fate Asymmetry in Caulobacter crescentus
journal, March 2011
- Tsokos, Christos G.; Perchuk, Barrett S.; Laub, Michael T.
- Developmental Cell, Vol. 20, Issue 3
A bacterial control circuit integrates polar localization and proteolysis of key regulatory proteins with a phospho-signaling cascade
journal, October 2008
- Iniesta, A. A.; Shapiro, L.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 43
Cell pole-specific activation of a critical bacterial cell cycle kinase
journal, March 2010
- Iniesta, A. A.; Hillson, N. J.; Shapiro, L.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 15
A novel bacterial tyrosine kinase essential for cell division and differentiation
journal, November 1999
- Wu, J.; Ohta, N.; Zhao, J. -L.
- Proceedings of the National Academy of Sciences, Vol. 96, Issue 23
The essential genome of a bacterium
journal, January 2011
- Christen, Beat; Abeliuk, Eduardo; Collier, John M.
- Molecular Systems Biology, Vol. 7, Issue 1
The diversity and evolution of cell cycle regulation in alpha-proteobacteria: a comparative genomic analysis
journal, January 2010
- Brilli, Matteo; Fondi, Marco; Fani, Renato
- BMC Systems Biology, Vol. 4, Issue 1
MolProbity : all-atom structure validation for macromolecular crystallography
journal, December 2009
- Chen, Vincent B.; Arendall, W. Bryan; Headd, Jeffrey J.
- Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 1
Structural Insight into Partner Specificity and Phosphoryl Transfer in Two-Component Signal Transduction
journal, October 2009
- Casino, Patricia; Rubio, Vicente; Marina, Alberto
- Cell, Vol. 139, Issue 2
Structure of the entire cytoplasmic portion of a sensor histidine-kinase protein
journal, December 2005
- Marina, Alberto; Waldburger, Carey D.; Hendrickson, Wayne A.
- The EMBO Journal, Vol. 24, Issue 24
Structure of PAS-Linked Histidine Kinase and the Response Regulator Complex
journal, October 2009
- Yamada, Seiji; Sugimoto, Hiroshi; Kobayashi, Miki
- Structure, Vol. 17, Issue 10
Mechanistic Insights Revealed by the Crystal Structure of a Histidine Kinase with Signal Transducer and Sensor Domains
journal, February 2013
- Wang, Chen; Sang, Jiayan; Wang, Jiawei
- PLoS Biology, Vol. 11, Issue 2
Visualizing autophosphorylation in histidine kinases
journal, February 2014
- Casino, Patricia; Miguel-Romero, Laura; Marina, Alberto
- Nature Communications, Vol. 5, Issue 1
Full-Length Structure of a Sensor Histidine Kinase Pinpoints Coaxial Coiled Coils as Signal Transducers and Modulators
journal, July 2013
- Diensthuber, Ralph P.; Bommer, Martin; Gleichmann, Tobias
- Structure, Vol. 21, Issue 7
Ligand-Induced Asymmetry in Histidine Sensor Kinase Complex Regulates Quorum Sensing
journal, September 2006
- Neiditch, Matthew B.; Federle, Michael J.; Pompeani, Audra J.
- Cell, Vol. 126, Issue 6
How to Switch Off a Histidine Kinase: Crystal Structure of Geobacillus stearothermophilus KinB with the inhibitor Sda
journal, February 2009
- Bick, Matthew J.; Lamour, Valerie; Rajashankar, Kanagalaghatta R.
- Journal of Molecular Biology, Vol. 386, Issue 1
Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation
journal, January 2014
- Mechaly, Ariel E.; Sassoon, Nathalie; Betton, Jean-Michel
- PLoS Biology, Vol. 12, Issue 1
Structural basis of histidine kinase autophosphorylation deduced by integrating genomics, molecular dynamics, and mutagenesis
journal, June 2012
- Dago, A. E.; Schug, A.; Procaccini, A.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 26
TNP-ATP and TNP-ADP as Probes of the Nucleotide Binding Site of CheA, the Histidine Protein Kinase in the Chemotaxis Signal Transduction Pathway of Escherichia coli †
journal, September 1998
- Stewart, Richard C.; VanBruggen, Ricaele; Ellefson, Dolph D.
- Biochemistry, Vol. 37, Issue 35
Oxygen Blocks the Reaction of the FixL−FixJ Complex with ATP but Does Not Influence Binding of FixJ or ATP to FixL †
journal, November 2005
- Sousa, Eduardo Henrique Silva; Gonzalez, Gonzalo; Gilles-Gonzalez, Marie-Alda
- Biochemistry, Vol. 44, Issue 46
Probing the Nucleotide Binding Domain of the Osmoregulator EnvZ Using Fluorescent Nucleotide Derivatives †
journal, November 2002
- Plesniak, Leigh; Horiuchi, Yuki; Sem, Daniel
- Biochemistry, Vol. 41, Issue 47
Probing the nucleotide binding and phosphorylation by the histidine kinase of a novel three-protein two-component system from Mycobacterium tuberculosis
journal, April 2007
- Shrivastava, Rashmi; Ghosh, Ananta Kumar; Das, Amit Kumar
- FEBS Letters, Vol. 581, Issue 9
A High-Throughput TNP-ATP Displacement Assay for Screening Inhibitors of ATP-Binding in Bacterial Histidine Kinases
journal, April 2011
- Guarnieri, Michael T.; Blagg, Brian S. J.; Zhao, Rui
- ASSAY and Drug Development Technologies, Vol. 9, Issue 2
A comprehensive set of plasmids for vanillate- and xylose-inducible gene expression in Caulobacter crescentus
journal, November 2007
- Thanbichler, M.; Iniesta, A. A.; Shapiro, L.
- Nucleic Acids Research, Vol. 35, Issue 20
Identification of direct residue contacts in protein-protein interaction by message passing
journal, December 2008
- Weigt, M.; White, R. A.; Szurmant, H.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 1
Features of Protein–Protein Interactions in Two‐Component Signaling Deduced from Genomic Libraries
book, January 2007
- White, Robert A.; Szurmant, Hendrik; Hoch, James A.
- Methods in Enzymology
Systematic Dissection and Trajectory-Scanning Mutagenesis of the Molecular Interface That Ensures Specificity of Two-Component Signaling Pathways
journal, November 2010
- Capra, Emily J.; Perchuk, Barrett S.; Lubin, Emma A.
- PLoS Genetics, Vol. 6, Issue 11
Rewiring the Specificity of Two-Component Signal Transduction Systems
journal, June 2008
- Skerker, Jeffrey M.; Perchuk, Barrett S.; Siryaporn, Albert
- Cell, Vol. 133, Issue 6
Branched Signal Wiring of an Essential Bacterial Cell-Cycle Phosphotransfer Protein
journal, September 2013
- Blair, Jimmy A.; Xu, Qingping; Childers, W. Seth
- Structure, Vol. 21, Issue 9
Kinetic Characterization of the WalRKSpn (VicRK) Two-Component System of Streptococcus pneumoniae: Dependence of WalKSpn (VicK) Phosphatase Activity on Its PAS Domain
journal, February 2010
- Gutu, Alina D.; Wayne, Kyle J.; Sham, Lok-To
- Journal of Bacteriology, Vol. 192, Issue 9
Activation and Inhibition of the Receptor Histidine Kinase AgrC Occurs through Opposite Helical Transduction Motions
journal, March 2014
- Wang, Boyuan; Zhao, Aishan; Novick, Richard P.
- Molecular Cell, Vol. 53, Issue 6
Structural plasticity and catalysis regulation of a thermosensor histidine kinase
journal, September 2009
- Albanesi, D.; Martin, M.; Trajtenberg, F.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 38
The Two Active Sites of Thermotoga maritima CheA Dimers Bind ATP with Dramatically Different Affinities
journal, July 2009
- Eaton, Anna K.; Stewart, Richard C.
- Biochemistry, Vol. 48, Issue 27
Regulation of the bacterial cell cycle by an integrated genetic circuit
journal, November 2006
- Biondi, Emanuele G.; Reisinger, Sarah J.; Skerker, Jeffrey M.
- Nature, Vol. 444, Issue 7121
The HHpred interactive server for protein homology detection and structure prediction
journal, July 2005
- Soding, J.; Biegert, A.; Lupas, A. N.
- Nucleic Acids Research, Vol. 33, Issue Web Server
XDS
journal, January 2010
- Kabsch, Wolfgang
- Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2
A short history of SHELX
journal, December 2007
- Sheldrick, George M.
- Acta Crystallographica Section A Foundations of Crystallography, Vol. 64, Issue 1, p. 112-122
The Buccaneer software for automated model building. 1. Tracing protein chains
journal, August 2006
- Cowtan, Kevin
- Acta Crystallographica Section D Biological Crystallography, Vol. 62, Issue 9
Coot model-building tools for molecular graphics
journal, November 2004
- Emsley, Paul; Cowtan, Kevin
- Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
The CCP4 suite programs for protein crystallography
journal, September 1994
- ,
- Acta Crystallographica Section D Biological Crystallography, Vol. 50, Issue 5, p. 760-763
An SMC ATPase mutant disrupts chromosome segregation in Caulobacter: Role of the SMC ATPase in chromosome segregation
journal, September 2011
- Schwartz, Monica A.; Shapiro, Lucy
- Molecular Microbiology, Vol. 82, Issue 6
NADH-coupled microplate photometric assay for kinetic studies of ATP-hydrolyzing enzymes with low and high specific activities
journal, October 2003
- Kiianitsa, Konstantin; Solinger, Jachen A.; Heyer, Wolf-Dietrich
- Analytical Biochemistry, Vol. 321, Issue 2
Binding of guanosine 5'-triphosphate by soluble factors required for polypeptide synthesis.
journal, March 1968
- Ertel, R.; Brot, N.; Redfield, B.
- Proceedings of the National Academy of Sciences, Vol. 59, Issue 3
[22] Elongation factor Tu and the aminoacyl-tRNA · EFTu · GTP complex
book, January 1974
- Lee Miller, David; Weissbach, Herbert
- Methods in Enzymology
Communication Modules in Bacterial Signaling Proteins
journal, December 1992
- Parkinson, John S.; Kofoid, Eric C.
- Annual Review of Genetics, Vol. 26, Issue 1
Ligand-Induced Asymmetry in Histidine Sensor Kinase Complex Regulates Quorum Sensing
journal, September 2006
- Neiditch, Matthew B.; Federle, Michael J.; Pompeani, Audra J.
- Cell, Vol. 126, Issue 6
Allosteric Regulation of Histidine Kinases by Their Cognate Response Regulator Determines Cell Fate
journal, May 2008
- Paul, Ralf; Jaeger, Tina; Abel, Sören
- Cell, Vol. 133, Issue 3
Rewiring Bacteria, Two Components at a Time
journal, June 2008
- Kohanski, Michael A.; Collins, James J.
- Cell, Vol. 133, Issue 6
A Dynamic Complex of Signaling Proteins Uses Polar Localization to Regulate Cell-Fate Asymmetry in Caulobacter crescentus
journal, March 2011
- Tsokos, Christos G.; Perchuk, Barrett S.; Laub, Michael T.
- Developmental Cell, Vol. 20, Issue 3
Probing the nucleotide binding and phosphorylation by the histidine kinase of a novel three-protein two-component system from Mycobacterium tuberculosis
journal, April 2007
- Shrivastava, Rashmi; Ghosh, Ananta Kumar; Das, Amit Kumar
- FEBS Letters, Vol. 581, Issue 9
Structure of PAS-Linked Histidine Kinase and the Response Regulator Complex
journal, October 2009
- Yamada, Seiji; Sugimoto, Hiroshi; Kobayashi, Miki
- Structure, Vol. 17, Issue 10
Full-Length Structure of a Sensor Histidine Kinase Pinpoints Coaxial Coiled Coils as Signal Transducers and Modulators
journal, July 2013
- Diensthuber, Ralph P.; Bommer, Martin; Gleichmann, Tobias
- Structure, Vol. 21, Issue 7
Branched Signal Wiring of an Essential Bacterial Cell-Cycle Phosphotransfer Protein
journal, September 2013
- Blair, Jimmy A.; Xu, Qingping; Childers, W. Seth
- Structure, Vol. 21, Issue 9
Probing the Nucleotide Binding Domain of the Osmoregulator EnvZ Using Fluorescent Nucleotide Derivatives †
journal, November 2002
- Plesniak, Leigh; Horiuchi, Yuki; Sem, Daniel
- Biochemistry, Vol. 41, Issue 47
Oxygen Blocks the Reaction of the FixL−FixJ Complex with ATP but Does Not Influence Binding of FixJ or ATP to FixL †
journal, November 2005
- Sousa, Eduardo Henrique Silva; Gonzalez, Gonzalo; Gilles-Gonzalez, Marie-Alda
- Biochemistry, Vol. 44, Issue 46
The Two Active Sites of Thermotoga maritima CheA Dimers Bind ATP with Dramatically Different Affinities
journal, July 2009
- Eaton, Anna K.; Stewart, Richard C.
- Biochemistry, Vol. 48, Issue 27
Regulation of the bacterial cell cycle by an integrated genetic circuit
journal, November 2006
- Biondi, Emanuele G.; Reisinger, Sarah J.; Skerker, Jeffrey M.
- Nature, Vol. 444, Issue 7121
Visualizing autophosphorylation in histidine kinases
journal, February 2014
- Casino, Patricia; Miguel-Romero, Laura; Marina, Alberto
- Nature Communications, Vol. 5, Issue 1
Structure of the entire cytoplasmic portion of a sensor histidine-kinase protein
journal, December 2005
- Marina, Alberto; Waldburger, Carey D.; Hendrickson, Wayne A.
- The EMBO Journal, Vol. 24, Issue 24
Recruitment of a cytoplasmic response regulator to the cell pole is linked to its cell cycle-regulated proteolysis
journal, April 2004
- Ryan, K. R.; Huntwork, S.; Shapiro, L.
- Proceedings of the National Academy of Sciences, Vol. 101, Issue 19
Dynamic localization of a cytoplasmic signal transduction response regulator controls morphogenesis during the Caulobacter cell cycle
journal, March 2001
- Jacobs, C.; Hung, D.; Shapiro, L.
- Proceedings of the National Academy of Sciences, Vol. 98, Issue 7
A bacterial control circuit integrates polar localization and proteolysis of key regulatory proteins with a phospho-signaling cascade
journal, October 2008
- Iniesta, A. A.; Shapiro, L.
- Proceedings of the National Academy of Sciences, Vol. 105, Issue 43
Structural plasticity and catalysis regulation of a thermosensor histidine kinase
journal, September 2009
- Albanesi, D.; Martin, M.; Trajtenberg, F.
- Proceedings of the National Academy of Sciences, Vol. 106, Issue 38
Cell pole-specific activation of a critical bacterial cell cycle kinase
journal, March 2010
- Iniesta, A. A.; Hillson, N. J.; Shapiro, L.
- Proceedings of the National Academy of Sciences, Vol. 107, Issue 15
Structural basis of histidine kinase autophosphorylation deduced by integrating genomics, molecular dynamics, and mutagenesis
journal, June 2012
- Dago, A. E.; Schug, A.; Procaccini, A.
- Proceedings of the National Academy of Sciences, Vol. 109, Issue 26
Binding of guanosine 5'-triphosphate by soluble factors required for polypeptide synthesis.
journal, March 1968
- Ertel, R.; Brot, N.; Redfield, B.
- Proceedings of the National Academy of Sciences, Vol. 59, Issue 3
A novel bacterial tyrosine kinase essential for cell division and differentiation
journal, November 1999
- Wu, J.; Ohta, N.; Zhao, J. -L.
- Proceedings of the National Academy of Sciences, Vol. 96, Issue 23
Phosphorylation Alters the Interaction of the Response Regulator OmpR with Its Sensor Kinase EnvZ
journal, January 2002
- Mattison, Kirsten; Kenney, Linda J.
- Journal of Biological Chemistry, Vol. 277, Issue 13
A High-Throughput TNP-ATP Displacement Assay for Screening Inhibitors of ATP-Binding in Bacterial Histidine Kinases
journal, April 2011
- Guarnieri, Michael T.; Blagg, Brian S. J.; Zhao, Rui
- ASSAY and Drug Development Technologies, Vol. 9, Issue 2
The HHpred interactive server for protein homology detection and structure prediction
journal, July 2005
- Soding, J.; Biegert, A.; Lupas, A. N.
- Nucleic Acids Research, Vol. 33, Issue Web Server
A comprehensive set of plasmids for vanillate- and xylose-inducible gene expression in Caulobacter crescentus
journal, November 2007
- Thanbichler, M.; Iniesta, A. A.; Shapiro, L.
- Nucleic Acids Research, Vol. 35, Issue 20
Integration of Rotation and Piston Motions in Coiled-Coil Signal Transduction
journal, June 2007
- Gao, Rong; Lynn, David G.
- Journal of Bacteriology, Vol. 189, Issue 16
Polar Remodeling and Histidine Kinase Activation, Which Is Essential for Caulobacter Cell Cycle Progression, Are Dependent on DNA Replication Initiation
journal, June 2010
- Iniesta, Antonio A.; Hillson, Nathan J.; Shapiro, Lucy
- Journal of Bacteriology, Vol. 192, Issue 15
The Core Dimerization Domains of Histidine Kinases Contain Recognition Specificity for the Cognate Response Regulator
journal, August 2003
- Ohta, Noriko; Newton, Austin
- Journal of Bacteriology, Vol. 185, Issue 15
High-Resolution Anatomy of a Progressively Pinching Cell Division
journal, October 2005
- Maddock, Janine R.
- Journal of Bacteriology, Vol. 187, Issue 20
Mutations in DivL and CckA Rescue a divJ Null Mutant of Caulobacter crescentus by Reducing the Activity of CtrA
journal, April 2006
- Pierce, Deanne L.; O'Donnol, Danielle S.; Allen, Rebecca C.
- Journal of Bacteriology, Vol. 188, Issue 7
Specificity Residues Determine Binding Affinity for Two-Component Signal Transduction Systems
journal, November 2013
- Willett, Jonathan W.; Tiwari, Nitija; Müller, Susanne
- mBio, Vol. 4, Issue 6
Communication Modules in Bacterial Signaling Proteins
journal, December 1992
- Parkinson, John S.; Kofoid, Eric C.
- Annual Review of Genetics, Vol. 26, Issue 1
The diversity and evolution of cell cycle regulation in alpha-proteobacteria: a comparative genomic analysis
journal, January 2010
- Brilli, Matteo; Fondi, Marco; Fani, Renato
- BMC Systems Biology, Vol. 4, Issue 1
Segmental Helical Motions and Dynamical Asymmetry Modulate Histidine Kinase Autophosphorylation
journal, January 2014
- Mechaly, Ariel E.; Sassoon, Nathalie; Betton, Jean-Michel
- PLoS Biology, Vol. 12, Issue 1
Interplay between the Localization and Kinetics of Phosphorylation in Flagellar Pole Development of the Bacterium Caulobacter crescentus
journal, August 2012
- Tropini, Carolina; Huang, Kerwyn Casey
- PLoS Computational Biology, Vol. 8, Issue 8
Role of the VirA histidine autokinase of Agrobacterium tumefaciens in the initial steps of pathogenesis
journal, May 2014
- Lin, Yi-Han; Pierce, B. Daniel; Fang, Fang
- Frontiers in Plant Science, Vol. 5
Works referencing / citing this record:
Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication
journal, May 2015
- Lori, C.; Ozaki, S.; Steiner, S.
- Nature, Vol. 523, Issue 7559
miRNA863-3p sequentially targets negative immune regulator ARLPKs and positive regulator SERRATE upon bacterial infection
journal, April 2016
- Niu, Dongdong; Lii, Yifan E.; Chellappan, Padmanabhan
- Nature Communications, Vol. 7, Issue 1
Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa
journal, June 2018
- Francis, Vanessa I.; Waters, Elaine M.; Finton-James, Sutharsan E.
- Nature Communications, Vol. 9, Issue 1
Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation
journal, April 2018
- Rodriguez-Beltran, Jeronimo; Hernandez-Beltran, J. Carlos R.; DelaFuente, Javier
- Nature Ecology & Evolution, Vol. 2, Issue 5
Selective sequestration of signalling proteins in a membraneless organelle reinforces the spatial regulation of asymmetry in Caulobacter crescentus
journal, January 2020
- Lasker, Keren; von Diezmann, Lexy; Zhou, Xiaofeng
- Nature Microbiology, Vol. 5, Issue 3
Dynamic translation regulation in Caulobacter cell cycle control
journal, October 2016
- Schrader, Jared M.; Li, Gene-Wei; Childers, W. Seth
- Proceedings of the National Academy of Sciences, Vol. 113, Issue 44
Integration of cell cycle signals by multi-PAS domain kinases
journal, May 2018
- Mann, Thomas H.; Shapiro, Lucy
- Proceedings of the National Academy of Sciences
Absolute measurements of mRNA translation in C. crescentus reveal important fitness costs of vitamin B 12 scavenging
journal, February 2019
- Aretakis, James R.; Gega, Alisa; Schrader, Jared M.
- mSystems
Regulation of bacterial surface attachment by a network of sensory transduction proteins
journal, February 2019
- Reyes Ruiz, Leila M.; Fiebig, Aretha; Crosson, Sean
- PLOS Genetics
Reversed Signaling Flow of a Bacterial Pseudokinase
posted_content, October 2019
- Kowallis, Kimberly A.; Silfani, Elayna M.; Kasumu, Amanda P.
- BioRxiv
Classification of ab initio models of proteins restored from small-angle X-ray scattering
journal, August 2018
- Oide, Mao; Sekiguchi, Yuki; Fukuda, Asahi
- Journal of Synchrotron Radiation, Vol. 25, Issue 5
Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking
journal, September 2016
- Dubey, Badri N.; Lori, Christian; Ozaki, Shogo
- Science Advances, Vol. 2, Issue 9
Emerging concepts in pseudoenzyme classification, evolution, and signaling
journal, August 2019
- Ribeiro, António J. M.; Das, Sayoni; Dawson, Natalie
- Science Signaling, Vol. 12, Issue 594
The Protease ClpXP and the PAS Domain Protein DivL Regulate CtrA and Gene Transfer Agent Production in Rhodobacter capsulatus
journal, April 2018
- Westbye, Alexander B.; Kater, Lukas; Wiesmann, Christina
- Applied and Environmental Microbiology, Vol. 84, Issue 11
Absolute Measurements of mRNA Translation in Caulobacter crescentus Reveal Important Fitness Costs of Vitamin B 12 Scavenging
journal, May 2019
- Aretakis, James R.; Gega, Alisa; Schrader, Jared M.
- mSystems, Vol. 4, Issue 4
Regulation of bacterial surface attachment by a network of sensory transduction proteins
journal, May 2019
- Reyes Ruiz, Leila M.; Fiebig, Aretha; Crosson, Sean
- PLOS Genetics, Vol. 15, Issue 5
Integration of cell cycle signals by multi-PAS domain kinases
journal, July 2018
- Mann, Thomas H.; Shapiro, Lucy
- Proceedings of the National Academy of Sciences, Vol. 115, Issue 30
Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication
text, January 2015
- Lori, Christian; Ozaki, Shogo; Steiner, Samuel
- Macmillan
Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking
text, January 2016
- N., Dubey, Badri; Christian, Lori,; Shogo, Ozaki,
- University of Basel
miRNA863-3p sequentially targets negative immune regulator ARLPKs and positive regulator SERRATE upon bacterial infection
journal, April 2016
- Niu, Dongdong; Lii, Yifan E.; Chellappan, Padmanabhan
- Nature Communications, Vol. 7, Issue 1
A cell cycle kinase with tandem sensory PAS domains integrates cell fate cues
journal, April 2016
- Mann, Thomas H.; Seth Childers, W.; Blair, Jimmy A.
- Nature Communications, Vol. 7, Issue 1
Multicopy plasmids allow bacteria to escape from fitness trade-offs during evolutionary innovation
journal, April 2018
- Rodriguez-Beltran, Jeronimo; Hernandez-Beltran, J. Carlos R.; DelaFuente, Javier
- Nature Ecology & Evolution, Vol. 2, Issue 5
Reciprocal control of motility and biofilm formation by the PdhS2 two-component sensor kinase of Agrobacterium tumefaciens
journal, February 2019
- Heindl, Jason E.; Crosby, Daniel; Brar, Sukhdev
- Microbiology, Vol. 165, Issue 2
Cyclic di-GMP mediates a histidine kinase/phosphatase switch by noncovalent domain cross-linking
journal, September 2016
- Dubey, Badri N.; Lori, Christian; Ozaki, Shogo
- Science Advances, Vol. 2, Issue 9
Polar Organizing Protein PopZ Is Required for Chromosome Segregation in Agrobacterium tumefaciens
journal, September 2017
- Ehrle, Haley M.; Guidry, Jacob T.; Iacovetto, Rebecca
- Journal of Bacteriology, Vol. 199, Issue 17
Absolute Measurements of mRNA Translation in Caulobacter crescentus Reveal Important Fitness Costs of Vitamin B 12 Scavenging
journal, May 2019
- Aretakis, James R.; Gega, Alisa; Schrader, Jared M.
- mSystems, Vol. 4, Issue 4
Regulation of bacterial surface attachment by a network of sensory transduction proteins
journal, May 2019
- Reyes Ruiz, Leila M.; Fiebig, Aretha; Crosson, Sean
- PLOS Genetics, Vol. 15, Issue 5
Comparative Analysis ofWolbachiaGenomes Reveals Streamlining and Divergence of Minimalist Two-Component Systems
journal, May 2015
- Christensen, Steen; Serbus, Laura Renee
- G3 Genes|Genomes|Genetics, Vol. 5, Issue 5
Redefining bacterial origins of replication as centralized information processors
journal, June 2015
- Marczynski, Gregory T.; Rolain, Thomas; Taylor, James A.
- Frontiers in Microbiology, Vol. 6