Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery

Shirazi, Rahau S.; Ewert, Kai K.; Leal, Cecilia; Majzoub, Ramsey N.; Bouxsein, Nathan F.; Safinya, Cyrus R.

doi:10.1016/j.bbamem.2011.04.020

Title: Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery

Authors:: Shirazi, Rahau S.; Ewert, Kai K.; Leal, Cecilia; Majzoub, Ramsey N.; Bouxsein, Nathan F.; Safinya, Cyrus R.

Publication Date:: Thu Sep 01 00:00:00 EDT 2011

Sponsoring Org.:: USDOE

OSTI Identifier:: 1209611

Resource Type:: Published Article

Journal Name:: Biochimica et Biophysica Acta. Biomembranes

Additional Journal Information:: Journal Name: Biochimica et Biophysica Acta. Biomembranes Journal Volume: 1808 Journal Issue: 9; Journal ID: ISSN 0005-2736

Publisher:: Elsevier

Country of Publication:: Netherlands

Language:: English

Citation Formats


                    Shirazi, Rahau S., Ewert, Kai K., Leal, Cecilia, Majzoub, Ramsey N., Bouxsein, Nathan F., and Safinya, Cyrus R. Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery.  Netherlands: N. p., 2011. 
Web.  doi:10.1016/j.bbamem.2011.04.020.

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                    Shirazi, Rahau S., Ewert, Kai K., Leal, Cecilia, Majzoub, Ramsey N., Bouxsein, Nathan F., & Safinya, Cyrus R. Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery.  Netherlands.  https://doi.org/10.1016/j.bbamem.2011.04.020

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                    Shirazi, Rahau S., Ewert, Kai K., Leal, Cecilia, Majzoub, Ramsey N., Bouxsein, Nathan F., and Safinya, Cyrus R. Thu .  
"Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery".  Netherlands.  https://doi.org/10.1016/j.bbamem.2011.04.020.

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@article{osti_1209611,

  title        = {Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery},

  author       = {Shirazi, Rahau S. and Ewert, Kai K. and Leal, Cecilia and Majzoub, Ramsey N. and Bouxsein, Nathan F. and Safinya, Cyrus R.},

  abstractNote = {},

  doi          = {10.1016/j.bbamem.2011.04.020},

  journal      = {Biochimica et Biophysica Acta. Biomembranes},

  number       = 9,

  volume       = 1808,

  place        = {Netherlands},

  year         = {Thu Sep 01 00:00:00 EDT 2011},

  month        = {Thu Sep 01 00:00:00 EDT 2011}

}

Copy to clipboard

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Title: Synthesis and characterization of degradable multivalent cationic lipids with disulfide-bond spacers for gene delivery

Citation Formats

Structure and Structure—Function Studies of Lipid/Plasmid DNA Complexes journal, January 2000

Dendritic Cationic Lipids with Highly Charged Headgroups for Efficient Gene Delivery journal, July 2006

Condensation of DNA by multivalent cations: Considerations on mechanism journal, November 1991

Lipid-based Nanoparticles for Nucleic Acid Delivery journal, January 2007

Cationic Liposomes for Gene Therapy journal, August 1998

Intracellular Delivery of Nanometric DNA Particles via the Folate Receptor journal, July 2002

A Simple, High-Resolution Method for Establishing DNA Binding Affinity and Sequence Selectivity journal, June 2001

New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: lipid-DNA complexes for gene delivery journal, January 2005

Counterion-induced condensation of deoxyribonucleic acid. A light-scattering study journal, May 1979

GENE THERAPY: Safer and Virus-Free? journal, November 2001

A Columnar Phase of Dendritic Lipid−Based Cationic Liposome−DNA Complexes for Gene Delivery: Hexagonally Ordered Cylindrical Micelles Embedded in a DNA Honeycomb Lattice journal, March 2006

Use of an Aqueous Soluble Tetrazolium/Formazan Assay for Cell Growth Assays in Culture journal, July 1991

Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities journal, February 2003

Cationic lipids used in gene transfer journal, August 1997

Three-Dimensional Imaging of Lipid Gene-Carriers: Membrane Charge Density Controls Universal Transfection Behavior in Lamellar Cationic Liposome-DNA Complexes journal, May 2003

Introduction of a Disulfide Bond into a Cationic Lipid Enhances Transgene Expression of Plasmid DNA journal, January 1998

Use of Dithiodiglycolic Acid as a Tether for Cationic Lipids Decreases the Cytotoxicity and Increases Transgene Expression of Plasmid DNA in Vitro journal, September 1999

Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer journal, September 2003

Polyplex gene delivery modulated by redox potential gradients journal, January 2006

Gene therapy progress and prospects: non-viral gene therapy by systemic delivery journal, September 2006

Toxicity of cationic lipids and cationic polymers in gene delivery journal, August 2006

Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer journal, December 1997

BIOMEDICINE:Gene Therapy on Trial journal, May 2000

DNA condensation by multivalent cations journal, January 1997

Structure and Function of Lipid-DNA Complexes for Gene Delivery journal, June 2000

Structure and Gene Silencing Activities of Monovalent and Pentavalent Cationic Lipid Vectors Complexed with siRNA † journal, April 2007

Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. journal, September 1989

Glutathione journal, June 1983

The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products journal, January 1981

High-Resolution assessment of protein DNA binding affinity and selectivity utilizing a fluorescent intercalator displacement (FID) assay journal, November 2003

Gene therapy clinical trials worldwide to 2007—an update journal, January 2007

Overcoming the Obstacles to Gene Therapy journal, June 1997

Penetration of protein toxins into cells journal, August 2000

Human gene therapy comes of age journal, June 1992

Reduction-sensitive polymers and bioconjugates for biomedical applications journal, April 2009

Poly( l -glutamic acid) Gd(III)-DOTA Conjugate with a Degradable Spacer for Magnetic Resonance Imaging journal, July 2003

Reduction-Sensitive Lipopolyamines as a Novel Nonviral Gene Delivery System for Modulated Release of DNA with Improved Transgene Expression journal, November 2000

Efficient Synthesis and Cell-Transfection Properties of a New Multivalent Cationic Lipid for Nonviral Gene Delivery journal, November 2002

Reversible covalent attachment of cholesterol to oligodeoxyribonucleotides for studies of the mechanisms of their penetration into eucaryotic cells journal, January 1993

Gene therapeutics journal, January 1991

Gene therapy strategies for pulmonary disease journal, June 1992

Gene therapy clinical trials worldwide 1989–2004—an overview journal, May 2004

LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1 journal, October 2003

DNA Aggregation Induced by Polyamines and Cobalthexamine journal, March 1996

Monomolecular DNA Nanoparticles for Intravenous Delivery of Genes journal, August 2005

Synthesis of Sulfhydryl Cross-Linking Poly(Ethylene Glycol)-Peptides and Glycopeptides as Carriers for Gene Delivery † journal, March 2002

The Problem with Cationic Liposome / Micelle-Based Non-Viral Vector Systems for Gene Therapy journal, July 2003

Human gene therapy journal, May 1992

Gene Transfer with Synthetic Cationic Amphiphiles: Prospects for Gene Therapy journal, September 1994

Rapid chromatographic technique for preparative separations with moderate resolution journal, July 1978

Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease journal, April 2000

Gene Therapy Progress and Prospects: Nonviral vectors journal, November 2002

"Cleavable Trifunctional" Approach to Receptor Affinity Labeling: Regeneration of Binding to A1-Adenosine Receptors journal, May 1995

Reducible cationic lipids for gene transfer journal, June 2001

A Serious Adverse Event after Successful Gene Therapy for X-Linked Severe Combined Immunodeficiency journal, January 2003

Synthesis of Novel Cationic Poly(Ethylene Glycol) Containing Lipids journal, May 1999

Cationic Lipid-DNA Complexes for Gene Therapy: Understanding the Relationship Between Complex Structure and Gene Delivery Pathways at the Molecular Level journal, January 2004

A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung. journal, October 1996

DNA condensation journal, June 1996

Mechanisms of Liver Injury. III. Role of glutathione redox status in liver injury journal, July 2006

Biodegradable cystamine spacer facilitates the clearance of Gd(III) chelates in poly(glutamic acid) Gd-DO3A conjugates for contrast-enhanced MR imaging journal, September 2006

Structure and Structure—Function Studies of Lipid/Plasmid DNA Complexes
journal, January 2000

Dendritic Cationic Lipids with Highly Charged Headgroups for Efficient Gene Delivery
journal, July 2006

Condensation of DNA by multivalent cations: Considerations on mechanism
journal, November 1991

Lipid-based Nanoparticles for Nucleic Acid Delivery
journal, January 2007

Cationic Liposomes for Gene Therapy
journal, August 1998

Intracellular Delivery of Nanometric DNA Particles via the Folate Receptor
journal, July 2002

A Simple, High-Resolution Method for Establishing DNA Binding Affinity and Sequence Selectivity
journal, June 2001

New multivalent cationic lipids reveal bell curve for transfection efficiency versus membrane charge density: lipid-DNA complexes for gene delivery
journal, January 2005

Counterion-induced condensation of deoxyribonucleic acid. A light-scattering study
journal, May 1979

GENE THERAPY: Safer and Virus-Free?
journal, November 2001

A Columnar Phase of Dendritic Lipid−Based Cationic Liposome−DNA Complexes for Gene Delivery: Hexagonally Ordered Cylindrical Micelles Embedded in a DNA Honeycomb Lattice
journal, March 2006

Use of an Aqueous Soluble Tetrazolium/Formazan Assay for Cell Growth Assays in Culture
journal, July 1991

Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities
journal, February 2003

Cationic lipids used in gene transfer
journal, August 1997

Three-Dimensional Imaging of Lipid Gene-Carriers: Membrane Charge Density Controls Universal Transfection Behavior in Lamellar Cationic Liposome-DNA Complexes
journal, May 2003

Introduction of a Disulfide Bond into a Cationic Lipid Enhances Transgene Expression of Plasmid DNA
journal, January 1998

Use of Dithiodiglycolic Acid as a Tether for Cationic Lipids Decreases the Cytotoxicity and Increases Transgene Expression of Plasmid DNA in Vitro
journal, September 1999

Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer
journal, September 2003

Polyplex gene delivery modulated by redox potential gradients
journal, January 2006

Gene therapy progress and prospects: non-viral gene therapy by systemic delivery
journal, September 2006

Toxicity of cationic lipids and cationic polymers in gene delivery
journal, August 2006

Virus-sized self-assembling lamellar complexes between plasmid DNA and cationic micelles promote gene transfer
journal, December 1997

BIOMEDICINE:Gene Therapy on Trial
journal, May 2000

DNA condensation by multivalent cations
journal, January 1997

Structure and Function of Lipid-DNA Complexes for Gene Delivery
journal, June 2000

Structure and Gene Silencing Activities of Monovalent and Pentavalent Cationic Lipid Vectors Complexed with siRNA ^†
journal, April 2007

Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA.
journal, September 1989

Glutathione
journal, June 1983

The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products
journal, January 1981

High-Resolution assessment of protein DNA binding affinity and selectivity utilizing a fluorescent intercalator displacement (FID) assay
journal, November 2003

Gene therapy clinical trials worldwide to 2007—an update
journal, January 2007

Overcoming the Obstacles to Gene Therapy
journal, June 1997

Penetration of protein toxins into cells
journal, August 2000

Human gene therapy comes of age
journal, June 1992

Reduction-sensitive polymers and bioconjugates for biomedical applications
journal, April 2009

Poly( l -glutamic acid) Gd(III)-DOTA Conjugate with a Degradable Spacer for Magnetic Resonance Imaging
journal, July 2003

Reduction-Sensitive Lipopolyamines as a Novel Nonviral Gene Delivery System for Modulated Release of DNA with Improved Transgene Expression
journal, November 2000

Efficient Synthesis and Cell-Transfection Properties of a New Multivalent Cationic Lipid for Nonviral Gene Delivery
journal, November 2002

Reversible covalent attachment of cholesterol to oligodeoxyribonucleotides for studies of the mechanisms of their penetration into eucaryotic cells
journal, January 1993

Gene therapeutics
journal, January 1991

Gene therapy strategies for pulmonary disease
journal, June 1992

Gene therapy clinical trials worldwide 1989–2004—an overview
journal, May 2004

LMO2-Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1
journal, October 2003

DNA Aggregation Induced by Polyamines and Cobalthexamine
journal, March 1996

Monomolecular DNA Nanoparticles for Intravenous Delivery of Genes
journal, August 2005

Synthesis of Sulfhydryl Cross-Linking Poly(Ethylene Glycol)-Peptides and Glycopeptides as Carriers for Gene Delivery ^†
journal, March 2002

The Problem with Cationic Liposome / Micelle-Based Non-Viral Vector Systems for Gene Therapy
journal, July 2003

Human gene therapy
journal, May 1992

Gene Transfer with Synthetic Cationic Amphiphiles: Prospects for Gene Therapy
journal, September 1994

Rapid chromatographic technique for preparative separations with moderate resolution
journal, July 1978

Gene Therapy of Human Severe Combined Immunodeficiency (SCID)-X1 Disease
journal, April 2000

Gene Therapy Progress and Prospects: Nonviral vectors
journal, November 2002

"Cleavable Trifunctional" Approach to Receptor Affinity Labeling: Regeneration of Binding to A1-Adenosine Receptors
journal, May 1995

Reducible cationic lipids for gene transfer
journal, June 2001

A Serious Adverse Event after Successful Gene Therapy for X-Linked Severe Combined Immunodeficiency
journal, January 2003

Synthesis of Novel Cationic Poly(Ethylene Glycol) Containing Lipids
journal, May 1999

Cationic Lipid-DNA Complexes for Gene Therapy: Understanding the Relationship Between Complex Structure and Gene Delivery Pathways at the Molecular Level
journal, January 2004

A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung.
journal, October 1996

DNA condensation
journal, June 1996

Mechanisms of Liver Injury. III. Role of glutathione redox status in liver injury
journal, July 2006

Biodegradable cystamine spacer facilitates the clearance of Gd(III) chelates in poly(glutamic acid) Gd-DO3A conjugates for contrast-enhanced MR imaging
journal, September 2006