Proteomics of ovarian cancer: functional insights and clinical applications
Abstract
In the past decade, there has been an increasing interest in applying proteomics to assist in understanding the pathogenesis of ovarian cancer, elucidating the mechanism of drug resistance, and in the development of biomarkers for early detection of ovarian cancer. Although ovarian cancer is a spectrum of different diseases, the strategies for diagnosis and treatment with surgery and adjuvant therapy are similar across ovarian cancer types, increasing the general applicability of discoveries made through proteomics research. While proteomic experiments face many difficulties which slow the pace of clinical applications, recent advances in proteomic technology contribute significantly to the identification of aberrant proteins and networks which can serve as targets for biomarker development and individualized therapies. This review provides a summary of the literature on proteomics’ contributions to ovarian cancer research and highlights the current issues, future directions, and challenges. In conclusion, we propose that protein-level characterization of primary lesion in ovarian cancer can decipher the mystery of this disease, improve diagnostic tools, and lead to more effective screening programs.
- Authors:
-
- Egybiotech for Research and Biotechnology, Alexandria (Egypt); Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Biological Sciences Division
- Publication Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States). Environmental Molecular Sciences Laboratory (EMSL)
- Sponsoring Org.:
- USDOE; National Cancer Institute (NCI); National Inst.of Health (NIH)
- OSTI Identifier:
- 1208724
- Report Number(s):
- PNNL-SA-111055
Journal ID: ISSN 0167-7659; 48666; 400412000
- Grant/Contract Number:
- AC05-76RL01830; 5U24 CA160019-03; ACN12003-001-00000
- Resource Type:
- Accepted Manuscript
- Journal Name:
- Cancer and Metastasis Reviews
- Additional Journal Information:
- Journal Volume: 34; Journal Issue: 1; Journal ID: ISSN 0167-7659
- Publisher:
- Springer
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES; 59 BASIC BIOLOGICAL SCIENCES; Ovarian cancer; Proteomics; Biomarker; Drug resistance; Subtypes; Environmental Molecular Sciences Laboratory
Citation Formats
Elzek, Mohamed A., and Rodland, Karin D. Proteomics of ovarian cancer: functional insights and clinical applications. United States: N. p., 2015.
Web. doi:10.1007/s10555-014-9547-8.
Elzek, Mohamed A., & Rodland, Karin D. Proteomics of ovarian cancer: functional insights and clinical applications. United States. https://doi.org/10.1007/s10555-014-9547-8
Elzek, Mohamed A., and Rodland, Karin D. Wed .
"Proteomics of ovarian cancer: functional insights and clinical applications". United States. https://doi.org/10.1007/s10555-014-9547-8. https://www.osti.gov/servlets/purl/1208724.
@article{osti_1208724,
title = {Proteomics of ovarian cancer: functional insights and clinical applications},
author = {Elzek, Mohamed A. and Rodland, Karin D.},
abstractNote = {In the past decade, there has been an increasing interest in applying proteomics to assist in understanding the pathogenesis of ovarian cancer, elucidating the mechanism of drug resistance, and in the development of biomarkers for early detection of ovarian cancer. Although ovarian cancer is a spectrum of different diseases, the strategies for diagnosis and treatment with surgery and adjuvant therapy are similar across ovarian cancer types, increasing the general applicability of discoveries made through proteomics research. While proteomic experiments face many difficulties which slow the pace of clinical applications, recent advances in proteomic technology contribute significantly to the identification of aberrant proteins and networks which can serve as targets for biomarker development and individualized therapies. This review provides a summary of the literature on proteomics’ contributions to ovarian cancer research and highlights the current issues, future directions, and challenges. In conclusion, we propose that protein-level characterization of primary lesion in ovarian cancer can decipher the mystery of this disease, improve diagnostic tools, and lead to more effective screening programs.},
doi = {10.1007/s10555-014-9547-8},
journal = {Cancer and Metastasis Reviews},
number = 1,
volume = 34,
place = {United States},
year = {Wed Mar 04 00:00:00 EST 2015},
month = {Wed Mar 04 00:00:00 EST 2015}
}
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Works referenced in this record:
Mining the Ovarian Cancer Ascites Proteome for Potential Ovarian Cancer Biomarkers
journal, December 2008
- Kuk, Cynthia; Kulasingam, Vathany; Gunawardana, C. Geeth
- Molecular & Cellular Proteomics, Vol. 8, Issue 4
Gene Expression Profiles Predict Early Relapse in Ovarian Cancer after Platinum-Paclitaxel Chemotherapy
journal, March 2005
- Hartmann, L. C.
- Clinical Cancer Research, Vol. 11, Issue 6
Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor
journal, July 1983
- Pan, Bin-Tao; Johnstone, Rose M.
- Cell, Vol. 33, Issue 3
Application of systems biology principles to protein biomarker discovery: Urinary exosomal proteome in renal transplantation
journal, June 2012
- Pisitkun, Trairak; Gandolfo, Maria T.; Das, Samarjit
- PROTEOMICS - Clinical Applications, Vol. 6, Issue 5-6
Genomic Predictors of Outcome and Treatment Response in Breast Cancer
journal, April 2009
- Dunn, Lara; DeMichele, Angela
- Molecular Diagnosis & Therapy, Vol. 13, Issue 2
Proteomic analyses of serous and endometrioid epithelial ovarian cancers - Cases studies - Molecular insights of a possible histological etiology of serous ovarian cancer
journal, June 2013
- Longuespée, Rémi; Gagnon, Hugo; Boyon, Charlotte
- PROTEOMICS - Clinical Applications, Vol. 7, Issue 5-6
Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)
journal, April 2009
- Menon, Usha; Gentry-Maharaj, Aleksandra; Hallett, Rachel
- The Lancet Oncology, Vol. 10, Issue 4
Therapeutic strategies in epithelial ovarian cancer
journal, January 2012
- Kim, Ayako; Ueda, Yutaka; Naka, Tetsuji
- Journal of Experimental & Clinical Cancer Research, Vol. 31, Issue 1
Label-Free LC-MSe in Tissue and Serum Reveals Protein Networks Underlying Differences between Benign and Malignant Serous Ovarian Tumors
journal, September 2014
- Wegdam, Wouter; Argmann, Carmen A.; Kramer, Gertjan
- PLoS ONE, Vol. 9, Issue 9
Proteomic Identification of Paclitaxel-Resistance Associated hnRNP A2 and GDI 2 Proteins in Human Ovarian Cancer Cells
journal, November 2010
- Lee, Dong Hyeon; Chung, Kwanghoe; Song, Ji-Ae
- Journal of Proteome Research, Vol. 9, Issue 11
Identification of Platinum-Resistance Associated Proteins through Proteomic Analysis of Human Ovarian Cancer Cells and Their Platinum-Resistant Sublines
journal, February 2007
- Yan, Xue-dong; Pan, Ling-ya; Yuan, Ye
- Journal of Proteome Research, Vol. 6, Issue 2
Historical perspective of peptidomics
journal, June 2014
- Schrader, Michael; Schulz-Knappe, Peter; Fricker, Lloyd D.
- EuPA Open Proteomics, Vol. 3
Quantitative mass spectrometry in proteomics: critical review update from 2007 to the present
journal, July 2012
- Bantscheff, Marcus; Lemeer, Simone; Savitski, Mikhail M.
- Analytical and Bioanalytical Chemistry, Vol. 404, Issue 4
Identification and proteomic profiling of exosomes in human cerebrospinal fluid
journal, January 2012
- Street, Jonathan M.; Barran, Perdita E.; Mackay, C. Logan
- Journal of Translational Medicine, Vol. 10, Issue 1
Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells
journal, October 2005
- Safaei, R.
- Molecular Cancer Therapeutics, Vol. 4, Issue 10
Proteomic analysis of post-translational modifications
journal, March 2003
- Mann, Matthias; Jensen, Ole N.
- Nature Biotechnology, Vol. 21, Issue 3
Genomic signatures to guide the use of chemotherapeutics
journal, October 2006
- Potti, Anil; Dressman, Holly K.; Bild, Andrea
- Nature Medicine, Vol. 12, Issue 11
Investigation of the Ovarian and Prostate Cancer Peptidome for Candidate Early Detection Markers Using a Novel Nanoparticle Biomarker Capture Technology
journal, June 2010
- Fredolini, Claudia; Meani, Francesco; Luchini, Alessandra
- The AAPS Journal, Vol. 12, Issue 4
THE CHRONOLOGY OF EARLY EPIC - (O.) Andersen, (D.T.T.) Haug (edd.) Relative Chronology in Early Greek Epic Poetry. Pp. xiv + 277, figs. Cambridge: Cambridge University Press, 2012. Cased, £60, US$99. ISBN: 978-0-521-19497-6.
journal, March 2014
- Hitch, Sarah
- The Classical Review, Vol. 64, Issue 1
Ovarian cancer molecular pathology
journal, June 2012
- Longuespée, Rémi; Boyon, C.; Desmons, Annie
- Cancer and Metastasis Reviews, Vol. 31, Issue 3-4
Comparative Proteomic Analysis of Paclitaxel Sensitive A2780 Epithelial Ovarian Cancer Cell Line and Its Resistant Counterpart A2780TC1 by 2D-DIGE: The Role of ERp57
journal, April 2009
- Cicchillitti, Lucia; Di Michele, Michela; Urbani, Andrea
- Journal of Proteome Research, Vol. 8, Issue 4
Ovarian Carcinoma Subtypes Are Different Diseases: Implications for Biomarker Studies
journal, December 2008
- Köbel, Martin; Kalloger, Steve E.; Boyd, Niki
- PLoS Medicine, Vol. 5, Issue 12
Effect of Screening on Ovarian Cancer Mortality: The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial
journal, June 2011
- Buys, Saundra S.
- JAMA, Vol. 305, Issue 22
A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation
journal, February 2014
- Wiegand, Kimberly C.; Hennessy, Bryan T.; Leung, Samuel
- BMC Cancer, Vol. 14, Issue 1
Prediction of optimal versus suboptimal cytoreduction of advanced-stage serous ovarian cancer with the use of microarrays
journal, April 2004
- Berchuck, Andrew; Iversen, Edwin S.; Lancaster, Johnathan M.
- American Journal of Obstetrics and Gynecology, Vol. 190, Issue 4
Diverse Tumorigenic Pathways in Ovarian Serous Carcinoma
journal, April 2002
- Singer, Gad; Kurman, Robert J.; Chang, Hsueh-Wei
- The American Journal of Pathology, Vol. 160, Issue 4
Proteomics by Mass Spectrometry: Approaches, Advances, and Applications
journal, August 2009
- Yates, John R.; Ruse, Cristian I.; Nakorchevsky, Aleksey
- Annual Review of Biomedical Engineering, Vol. 11, Issue 1
The dynamic range problem in the analysis of the plasma proteome
journal, January 2010
- Hortin, Glen L.; Sviridov, Denis
- Journal of Proteomics, Vol. 73, Issue 3
Quantitative Proteomics Analysis Identifies Mitochondria as Therapeutic Targets of Multidrug-Resistance in Ovarian Cancer
journal, January 2014
- Chen, Xiulan; Wei, Shasha; Ma, Ying
- Theranostics, Vol. 4, Issue 12
Serum biomarker panels for the discrimination of benign from malignant cases in patients with an adnexal mass
journal, June 2010
- Nolen, Brian; Velikokhatnaya, Liudmila; Marrangoni, Adele
- Gynecologic Oncology, Vol. 117, Issue 3
Exosomes: an overview of biogenesis, composition and role in ovarian cancer
journal, January 2014
- Beach, Allison; Zhang, Huang-Ge; Ratajczak, Mariusz Z.
- Journal of Ovarian Research, Vol. 7, Issue 1
Toward improving the proteomic analysis of formalin-fixed, paraffin-embedded tissue
journal, August 2013
- Fowler, Carol B.; O’Leary, Timothy J.; Mason, Jeffrey T.
- Expert Review of Proteomics, Vol. 10, Issue 4
Proteomic analysis reflects different histologic subtypes of epithelial ovarian cancer
journal, March 2012
- Jia, Lin; Zhang, Hui; Qu, Xun
- Medical Hypotheses, Vol. 78, Issue 3
A database of mass spectrometric assays for the yeast proteome
journal, November 2008
- Picotti, Paola; Lam, Henry; Campbell, David
- Nature Methods, Vol. 5, Issue 11
Differential Exoprotease Activities Confer Tumor-Specific Serum Peptidome Patterns
journal, April 2006
- Zlotta, Alexandre R.
- European Urology, Vol. 49, Issue 4
Human Epididymis Protein 4 (HE4) Is a Secreted Glycoprotein that Is Overexpressed by Serous and Endometrioid Ovarian Carcinomas
journal, March 2005
- Drapkin, Ronny; von Horsten, Hans Henning; Lin, Yafang
- Cancer Research, Vol. 65, Issue 6
Potential tumor biomarkers identified in ovarian cyst fluid by quantitative proteomic analysis, iTRAQ
journal, April 2013
- Kristjansdottir, Björg; Levan, Kristina; Partheen, Karolina
- Clinical Proteomics, Vol. 10, Issue 1
Glycoproteomic identification of potential glycoprotein biomarkers in ovarian cancer proximal fluids
journal, January 2013
- Kuzmanov, Uros; Musrap, Natasha; Kosanam, Hari
- Clinical Chemistry and Laboratory Medicine, Vol. 51, Issue 7
CA125 surveillance increases optimal resectability at secondary cytoreductive surgery for recurrent epithelial ovarian cancer
journal, May 2011
- Fleming, Nicole D.; Cass, Ilana; Walsh, Christine S.
- Gynecologic Oncology, Vol. 121, Issue 2
Integrated Proteomic Analysis of Human Cancer Cells and Plasma from Tumor Bearing Mice for Ovarian Cancer Biomarker Discovery
journal, November 2009
- Pitteri, Sharon J.; JeBailey, Lellean; Faça, Vitor M.
- PLoS ONE, Vol. 4, Issue 11
Management Strategies for Recurrent Platinum-Resistant Ovarian Cancer
journal, January 2011
- Naumann, R. Wendel; Coleman, Robert L.
- Drugs, Vol. 71, Issue 11
Prediction of optimal versus suboptimal cytoreduction of advanced-stage serious ovarian cancer with the use of microarrays
journal, September 2004
- ,
- The Women's Oncology Review, Vol. 4, Issue 3, p. 203-204
The Cell of Origin of Ovarian Epithelial Tumors and the Ovarian Surface Epithelium Dogma: Does the Emperor Have No Clothes?
journal, March 1999
- Dubeau, Louis
- Gynecologic Oncology, Vol. 72, Issue 3
HE4 and CA125 as a diagnostic test in ovarian cancer: prospective validation of the Risk of Ovarian Malignancy Algorithm
journal, February 2011
- Van Gorp, T.; Cadron, I.; Despierre, E.
- British Journal of Cancer, Vol. 104, Issue 5
Origin and Pathogenesis of Pelvic (Ovarian, Tubal, and Primary Peritoneal) Serous Carcinoma
journal, January 2014
- Nik, Niloofar N.; Vang, Russell; Shih, Ie-Ming
- Annual Review of Pathology: Mechanisms of Disease, Vol. 9, Issue 1
Identification of glycoproteins associated with different histological subtypes of ovarian tumors using quantitative glycoproteomics
journal, November 2011
- Tian, Yuan; Yao, Zhihao; Roden, Richard B. S.
- PROTEOMICS, Vol. 11, Issue 24
Prediction of optimal versus suboptimal cytoreduction of advanced-stage serious ovarian cancer with the use of microarrays
journal, September 2004
- Not Available, Not Available
- The Women's Oncology Review, Vol. 4, Issue 3
Mass spectrometry-based proteomics
journal, March 2003
- Aebersold, Ruedi; Mann, Matthias
- Nature, Vol. 422, Issue 6928
Comprehensive Analysis of Conditioned Media from Ovarian Cancer Cell Lines Identifies Novel Candidate Markers of Epithelial Ovarian Cancer
journal, October 2009
- Gunawardana, C. Geeth; Kuk, Cynthia; Smith, Chris R.
- Journal of Proteome Research, Vol. 8, Issue 10
A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation
text, January 2014
- Wiegand, Kimberly C.; Hennessy, Bryan T.; Leung, Samuel
- BioMed Central
A Proteome Resource of Ovarian Cancer Ascites: Integrated Proteomic and Bioinformatic Analyses To Identify Putative Biomarkers
journal, January 2008
- Gortzak-Uzan, Limor; Ignatchenko, Alex; Evangelou, Andreas I.
- Journal of Proteome Research, Vol. 7, Issue 1
The outcomes of ovarian cancer treatment are better when provided by gynecologic oncologists and in specialized hospitals: A systematic review
journal, June 2007
- Vernooij, Flora; Heintz, Peter; Witteveen, Els
- Gynecologic Oncology, Vol. 105, Issue 3
In-depth proteomic analyses of ovarian cancer cell line exosomes reveals differential enrichment of functional categories compared to the NCI 60 proteome
journal, March 2014
- Sinha, Ankit; Ignatchenko, Vladimir; Ignatchenko, Alex
- Biochemical and Biophysical Research Communications, Vol. 445, Issue 4
A Xenograft Mouse Model Coupled with In-depth Plasma Proteome Analysis Facilitates Identification of Novel Serum Biomarkers for Human Ovarian Cancer
journal, November 2011
- Tang, Hsin-Yao; Beer, Lynn A.; Chang-Wong, Tony
- Journal of Proteome Research, Vol. 11, Issue 2
Proteogenomic characterization of human colon and rectal cancer
journal, July 2014
- Zhang, Bing; Wang, Jing; Wang, Xiaojing
- Nature, Vol. 513, Issue 7518
Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling
journal, September 2010
- Chairoungdua, Arthit; Smith, Danielle L.; Pochard, Pierre
- The Journal of Cell Biology, Vol. 190, Issue 6
Variation and genetic control of protein abundance in humans
journal, May 2013
- Wu, Linfeng; Candille, Sophie I.; Choi, Yoonha
- Nature, Vol. 499, Issue 7456
Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence
journal, June 2004
- Blom, Nikolaj; Sicheritz-Pontén, Thomas; Gupta, Ramneek
- PROTEOMICS, Vol. 4, Issue 6
LC−MS/MS Analysis of Ovarian Cancer Metastasis-Related Proteins Using a Nude Mouse Model: 14-3-3 Zeta as a Candidate Biomarker
journal, December 2010
- He, Yifeng; Wu, Xin; Liu, Xiaohui
- Journal of Proteome Research, Vol. 9, Issue 12
Integrated genomic analyses of ovarian carcinoma
journal, June 2011
- Network, Atlas Research
- Nature, Vol. 474, Issue 7353, p. 609-615
Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis
journal, December 2009
- Abbott, Karen L.; Lim, Jae-Min; Wells, Lance
- PROTEOMICS, Vol. 10, Issue 3
Proteomic analysis of microvesicles in human saliva by gel electrophoresis with liquid chromatography-mass spectrometry
journal, April 2012
- Xiao, Hua; Wong, David T. W.
- Analytica Chimica Acta, Vol. 723
Proteomic tracking of serum protein isoforms as screening biomarkers of ovarian cancer
journal, October 2005
- Ahmed, Nuzhat; Oliva, Karen T.; Barker, Gillian
- PROTEOMICS, Vol. 5, Issue 17
Lessons from BRCA: The Tubal Fimbria Emerges as an Origin for Pelvic Serous Cancer
journal, March 2007
- Crum, C. P.; Drapkin, R.; Kindelberger, D.
- Clinical Medicine & Research, Vol. 5, Issue 1
PARP Inhibitors for BRCA1/2 mutation-associated and BRCA-like malignancies
journal, January 2014
- Lee, J-m.; Ledermann, J. A.; Kohn, E. C.
- Annals of Oncology, Vol. 25, Issue 1
The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory
journal, January 2010
- Kurman, Robert J.; Shih, Ie-Ming
- The American Journal of Surgical Pathology, Vol. 34, Issue 3
Evaluating cell lines as tumour models by comparison of genomic profiles
journal, July 2013
- Domcke, Silvia; Sinha, Rileen; Levine, Douglas A.
- Nature Communications, Vol. 4, Issue 1
A proteomic kinetic analysis of IGROV1 ovarian carcinoma cell line response to cisplatin treatment
journal, November 2007
- Le Moguen, Karen; Lincet, Hubert; Marcelo, Paulo
- PROTEOMICS, Vol. 7, Issue 22
Proteomic Analysis of Urinary Exosomes in Cardiovascular and Associated Kidney Diseases by Two-Dimensional Electrophoresis and LC–MS/MS
book, January 2013
- Zubiri, Irene; Vivanco, Fernando; Alvarez-Llamas, Gloria
- Methods in Molecular Biology
Integrated genomic analyses of ovarian carcinoma
text, January 2011
- Charles, Perou,
- The University of North Carolina at Chapel Hill University Libraries
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
journal, April 2005
- Farmer, Hannah; McCabe, Nuala; Lord, Christopher J.
- Nature, Vol. 434, Issue 7035
Mitochondrial comparative proteomics of human ovarian cancer cells and their platinum-resistant sublines
journal, October 2010
- Dai, Zhiqin; Yin, Jie; He, Haojie
- PROTEOMICS, Vol. 10, Issue 21
A Novel, High-Throughput Workflow for Discovery and Identification of Serum Carrier Protein-Bound Peptide Biomarker Candidates in Ovarian Cancer Samples
journal, June 2007
- Lopez, Mary F.; Mikulskis, Alvydas; Kuzdzal, Scott
- Clinical Chemistry, Vol. 53, Issue 6
Comparative Proteomics of Ovarian Epithelial Tumors
journal, May 2006
- An, Hee Jung; Kim, Dong Su; Park, Yong Kyu
- Journal of Proteome Research, Vol. 5, Issue 5
Characterization of serum biomarkers for detection of early stage ovarian cancer
journal, October 2005
- Kozak, Katherine R.; Su, Feng; Whitelegge, Julian P.
- PROTEOMICS, Vol. 5, Issue 17
Global quantification of mammalian gene expression control
journal, May 2011
- Schwanhäusser, Björn; Busse, Dorothea; Li, Na
- Nature, Vol. 473, Issue 7347
In 2014, can we do better than CA125 in the early detection of ovarian cancer?
journal, January 2014
- Cohen, Joshua G.
- World Journal of Biological Chemistry, Vol. 5, Issue 3
A randomized study of screening for ovarian cancer: a multicenter study in Japan
journal, May 2008
- Kobayashi, H.; Yamada, Y.; Sado, T.
- International Journal of Gynecologic Cancer, Vol. 18, Issue 3
Gene Expression Signature With Independent Prognostic Significance in Epithelial Ovarian Cancer
journal, December 2004
- Spentzos, Dimitrios; Levine, Douglas A.; Ramoni, Marco F.
- Journal of Clinical Oncology, Vol. 22, Issue 23
Proteomic characterization of ovarian cancers identifying annexin-A4, phosphoserine aminotransferase, cellular retinoic acid-binding protein 2, and serpin B5 as histology-specific biomarkers
journal, February 2012
- Toyama, Atsuhiko; Suzuki, Atsushi; Shimada, Takashi
- Cancer Science, Vol. 103, Issue 4
Early Detection of Ovarian Cancer: Promise and Reality
book, January 2002
- Bast, Jr., Robert C.; Urban, Nicole; Shridhar, Viji
- Cancer Treatment and Research
Intraepithelial Carcinoma of the Fimbria and Pelvic Serous Carcinoma: Evidence for a Causal Relationship
journal, January 2007
- Kindelberger, David W.; Lee, Yonghee; Miron, Alexander
- The American Journal of Surgical Pathology, Vol. 31, Issue 2
Mitochondrial comparative proteomics of human ovarian cancer cells and their platinum-resistant sublines
journal, March 2011
- Dai, Zhiqin; Yin, Jie; He, Haojie
- PROTEOMICS - Clinical Applications, Vol. 5, Issue 3-4
Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS).
journal, April 2009
- Menon, U.; Gentry-Maharaj, A.; Hallet, R.
- The Lancet Oncology, Vol. 10, Issue 4, p. 327-340
Glycoproteomics of paclitaxel resistance in human epithelial ovarian cancer cell lines: Towards the identification of putative biomarkers
journal, March 2010
- Di Michele, Michela; Marcone, Simone; Cicchillitti, Lucia
- Journal of Proteomics, Vol. 73, Issue 5
Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review
journal, May 2013
- Azmi, Asfar S.; Bao, Bin; Sarkar, Fazlul H.
- Cancer and Metastasis Reviews, Vol. 32, Issue 3-4
Investigation of ovarian cancer associated sialylation changes in N-linked glycopeptides by quantitative proteomics
journal, January 2012
- Shetty, Vivekananda; Hafner, Julie; Shah, Punit
- Clinical Proteomics, Vol. 9, Issue 1
Serum S100A6 Concentration Predicts Peritoneal Tumor Burden in Mice with Epithelial Ovarian Cancer and Is Associated with Advanced Stage in Patients
journal, October 2009
- Wei, Bih-Rong; Hoover, Shelley B.; Ross, Mark M.
- PLoS ONE, Vol. 4, Issue 10
Gene-expression profiling in epithelial ovarian cancer
journal, July 2008
- Konstantinopoulos, Panagiotis A.; Spentzos, Dimitrios; Cannistra, Stephen A.
- Nature Clinical Practice Oncology, Vol. 5, Issue 10
Molecular Cloning of the CA125 Ovarian Cancer Antigen: IDENTIFICATION AS A NEW MUCIN, MUC16
journal, May 2001
- Yin, Beatrice W. T.; Lloyd, Kenneth O.
- Journal of Biological Chemistry, Vol. 276, Issue 29
Ovarian cancer: strategies for overcoming resistance to chemotherapy
journal, July 2003
- Agarwal, Roshan; Kaye, Stan B.
- Nature Reviews Cancer, Vol. 3, Issue 7
Studies of the ‘hook’ effect in the one-step sandwich immunoassay
journal, July 1992
- Amarasiri Fernando, S.; Wilson, George S.
- Journal of Immunological Methods, Vol. 151, Issue 1-2
Functional Proteomic Analysis of Advanced Serous Ovarian Cancer Using Reverse Phase Protein Array: TGF- Pathway Signaling Indicates Response to Primary Chemotherapy
journal, May 2010
- Carey, M. S.; Agarwal, R.; Gilks, B.
- Clinical Cancer Research, Vol. 16, Issue 10
Exosomes with Immune Modulatory Features Are Present in Human Breast Milk
journal, July 2007
- Admyre, Charlotte; Johansson, Sara M.; Qazi, Khaleda Rahman
- The Journal of Immunology, Vol. 179, Issue 3
HE4 in ovarian cancer
book, September 2011
- Montagnana, M.; Danese, E.; Giudici, S.
- Advances in Clinical Chemistry
Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer—Shifting the paradigm
journal, July 2011
- Kurman, Robert J.; Shih, Ie-Ming
- Human Pathology, Vol. 42, Issue 7
A novel multiple marker bioassay utilizing HE4 and CA125 for the prediction of ovarian cancer in patients with a pelvic mass
journal, January 2009
- Moore, Richard G.; McMeekin, D. Scott; Brown, Amy K.
- Gynecologic Oncology, Vol. 112, Issue 1
Laser-capture microdissection
journal, June 2006
- Espina, Virginia; Wulfkuhle, Julia D.; Calvert, Valerie S.
- Nature Protocols, Vol. 1, Issue 2
Quantification of β-Catenin Signaling Components in Colon Cancer Cell Lines, Tissue Sections, and Microdissected Tumor Cells using Reaction Monitoring Mass Spectrometry
journal, August 2010
- Chen, Yi; Gruidl, Mike; Remily-Wood, Elizabeth
- Journal of Proteome Research, Vol. 9, Issue 8
Phosphoproteomics in cancer
journal, September 2010
- Harsha, H. C.; Pandey, Akhilesh
- Molecular Oncology, Vol. 4, Issue 6
The ROMA (Risk of Ovarian Malignancy Algorithm) for estimating the risk of epithelial ovarian cancer in women presenting with pelvic mass: is it really useful?
journal, January 2011
- Montagnana, Martina; Danese, Elisa; Ruzzenente, Orazio
- Clinical Chemistry and Laboratory Medicine, Vol. 49, Issue 3
Identification of candidate biomarkers with cancer-specific glycosylation in the tissue and serum of endometrioid ovarian cancer patients by glycoproteomic analysis
journal, September 2010
- Abbott, Karen L.; Lim, Jae-Min; Wells, Lance
- PROTEOMICS - Clinical Applications, Vol. 4, Issue 8-9
Proteomic search for potential diagnostic markers and therapeutic targets for ovarian clear cell adenocarcinoma
journal, November 2006
- Morita, Atsushi; Miyagi, Etsuko; Yasumitsu, Hidetaro
- PROTEOMICS, Vol. 6, Issue 21
Reverse-phase protein lysate microarrays for cell signaling analysis
journal, October 2008
- Spurrier, Brett; Ramalingam, Sundhar; Nishizuka, Satoshi
- Nature Protocols, Vol. 3, Issue 11
Extracellular vesicles: biology and emerging therapeutic opportunities
journal, April 2013
- EL Andaloussi, Samir; Mäger, Imre; Breakefield, Xandra O.
- Nature Reviews Drug Discovery, Vol. 12, Issue 5
Comparative proteome analysis of human epithelial ovarian cancer
journal, January 2007
- Gagné, Jean-Philippe; Éthier, Chantal; Gagné, Pierre
- Proteome Science, Vol. 5, Issue 1
Gene Expression Patterns in Ovarian Carcinomas
journal, November 2003
- Schaner, Marci E.; Ross, Douglas T.; Ciaravino, Giuseppe
- Molecular Biology of the Cell, Vol. 14, Issue 11
Classifications of ovarian cancer tissues by proteomic patterns
journal, November 2006
- Zhu, Yi; Wu, Rong; Sangha, Navneet
- PROTEOMICS, Vol. 6, Issue 21
Beyond chemotherapy: targeted therapies in ovarian cancer
journal, March 2009
- Yap, Timothy A.; Carden, Craig P.; Kaye, Stan B.
- Nature Reviews Cancer, Vol. 9, Issue 3
Enrichment techniques employed in phosphoproteomics
journal, October 2011
- Fíla, Jan; Honys, David
- Amino Acids, Vol. 43, Issue 3
Characterization and proteomic analysis of ovarian cancer-derived exosomes
journal, March 2013
- Liang, Bing; Peng, Peng; Chen, She
- Journal of Proteomics, Vol. 80
Screening for Ovarian Cancer: U.S. Preventive Services Task Force Reaffirmation Recommendation Statement
journal, December 2012
- Moyer, Virginia A.
- Annals of Internal Medicine, Vol. 157, Issue 12
Ovarian Conservation at the Time of Hysterectomy and Long-Term Health Outcomes in the Nurses’ Health Study
journal, January 2009
- Parker, William H.; Broder, Michael S.; Chang, Eunice
- Obstetrics & Gynecology, Vol. 113, Issue 5
Proteomic Analysis of Ovarian Cancer Cells Reveals Dynamic Processes of Protein Secretion and Shedding of Extra-Cellular Domains
journal, June 2008
- Faça, Vitor M.; Ventura, Aviva P.; Fitzgibbon, Mathew P.
- PLoS ONE, Vol. 3, Issue 6
Three new potential ovarian cancer biomarkers detected in human urine with equalizer bead technology
journal, January 2009
- Petri, Anette Lykke; Simonsen, Anja Hviid; Yip, Tai-Tung
- Acta Obstetricia et Gynecologica Scandinavica, Vol. 88, Issue 1
Mitochondrial Proteomic Analysis of Cisplatin Resistance in Ovarian Cancer
journal, August 2012
- Chappell, Nicole P.; Teng, Pang-ning; Hood, Brian L.
- Journal of Proteome Research, Vol. 11, Issue 9
Effectiveness of a Multivariate Index Assay in the Preoperative Assessment of Ovarian Tumors
journal, January 2011
- Ueland, Frederick R.; Desimone, Christopher P.; Seamon, Leigh G.
- Obstetrics & Gynecology, Vol. 117, Issue 6
The cell of origin of ovarian epithelial tumours
journal, December 2008
- Dubeau, Louis
- The Lancet Oncology, Vol. 9, Issue 12
A Randomized Study of Screening for Ovarian Cancer: A Multicenter Study in Japan
journal, January 2008
- Kobayashi, H.; Yamada, Y.; Sado, T.
- Obstetrical & Gynecological Survey, Vol. 63, Issue 10
Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma
journal, October 2013
- Kalra, Hina; Adda, Christopher G.; Liem, Michael
- PROTEOMICS, Vol. 13, Issue 22
Assessing the clinical utility of cancer genomic and proteomic data across tumor types
journal, June 2014
- Yuan, Yuan; Van Allen, Eliezer M.; Omberg, Larsson
- Nature Biotechnology, Vol. 32, Issue 7
Comparison of Serum Human Epididymis Protein 4 with Cancer Antigen 125 as a Tumor Marker in Patients with Malignant and Nonmalignant Diseases
journal, November 2011
- Escudero, Jose M.; Auge, Jose M.; Filella, Xavier
- Clinical Chemistry, Vol. 57, Issue 11
Three Biomarkers Identified from Serum Proteomic Analysis for the Detection of Early Stage Ovarian Cancer
journal, August 2004
- Zhang, Zhen; Bast, Robert C.; Yu, Yinhua
- Cancer Research, Vol. 64, Issue 16
The ovarian cancer-derived secretory/releasing proteome: A repertoire of tumor markers
journal, June 2012
- Zhang, Ying; Xu, Bin; Liu, Yu
- PROTEOMICS, Vol. 12, Issue 11
Evaluation of the Diagnostic Accuracy of the Risk of Ovarian Malignancy Algorithm in Women With a Pelvic Mass
journal, January 2011
- Moore, Richard G.; Miller, M. Craig; Disilvestro, Paul
- Obstetrics & Gynecology, Vol. 118, Issue 2, Part 1
Phase III Trial of Carboplatin and Paclitaxel Compared With Cisplatin and Paclitaxel in Patients With Optimally Resected Stage III Ovarian Cancer: A Gynecologic Oncology Group Study
journal, September 2003
- Ozols, Robert F.; Bundy, Brian N.; Greer, Benjamin E.
- Journal of Clinical Oncology, Vol. 21, Issue 17
Proteomic Analysis of Malignant Ovarian Cancer Effusions as a Tool for Biologic and Prognostic Profiling
journal, February 2006
- Davidson, B.
- Clinical Cancer Research, Vol. 12, Issue 3
Highlights on the capacities of "Gel-based" proteomics
journal, January 2010
- Chevalier, François
- Proteome Science, Vol. 8, Issue 1
An overview of biomarkers for the ovarian cancer diagnosis
journal, October 2011
- Zhang, Bei; Cai, Feng Feng; Zhong, Xiao Yan
- European Journal of Obstetrics & Gynecology and Reproductive Biology, Vol. 158, Issue 2
Committee Opinion No. 477: The Role of the Obstetrician–Gynecologist in the Early Detection of Epithelial Ovarian Cancer
journal, March 2011
- ,
- Obstetrics & Gynecology, Vol. 117, Issue 3, p. 742-746
Application of laser capture microdissection and proteomics in colon cancer
journal, August 2001
- Lawrie, L. C.
- Molecular Pathology, Vol. 54, Issue 4
Differential exoprotease activities confer tumor-specific serum peptidome patterns
journal, December 2005
- Villanueva, Josep; Shaffer, David R.; Philip, John
- Journal of Clinical Investigation, Vol. 116, Issue 1, p. 271-284
Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.
journal, August 1983
- Ciechanover, A.; Schwartz, A. L.; Dautry-Varsat, A.
- Journal of Biological Chemistry, Vol. 258, Issue 16
Works referencing / citing this record:
Novel Approaches in Ovarian Cancer Research against Heterogeneity, Late Diagnosis, Drug Resistance, and Transcoelomic Metastases
journal, May 2019
- Erol, Anna; Niemira, Magdalena; Krętowski, Adam Jacek
- International Journal of Molecular Sciences, Vol. 20, Issue 11
Sample Treatment for Saliva Proteomics
book, June 2019
- Amado, Francisco; Calheiros-Lobo, Maria João; Ferreira, Rita
- Advances in Experimental Medicine and Biology
MALDI-TOF-MS analysis in discovery and identification of serum proteomic patterns of ovarian cancer
journal, July 2017
- Swiatly, Agata; Horala, Agnieszka; Hajduk, Joanna
- BMC Cancer, Vol. 17, Issue 1
Highly-accurate metabolomic detection of early-stage ovarian cancer
journal, November 2015
- Gaul, David A.; Mezencev, Roman; Long, Tran Q.
- Scientific Reports, Vol. 5, Issue 1
Functional characterization of a panel of high-grade serous ovarian cancer cell lines as representative experimental models of the disease
journal, April 2016
- Haley, James; Tomar, Sunil; Pulliam, Nicholas
- Oncotarget, Vol. 7, Issue 22
MALDI-TOF-MS analysis in discovery and identification of serum proteomic patterns of ovarian cancer
journal, July 2017
- Swiatly, Agata; Horala, Agnieszka; Hajduk, Joanna
- BMC Cancer, Vol. 17, Issue 1
Targeted metabolomic profiling of low and high grade serous epithelial ovarian cancer tissues: a pilot study
journal, November 2018
- Garg, Gunjal; Yilmaz, Ali; Kumar, Praveen
- Metabolomics, Vol. 14, Issue 12
Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research
journal, October 2016
- Hughes, Christopher S.; McConechy, Melissa K.; Cochrane, Dawn R.
- Scientific Reports, Vol. 6, Issue 1
Mass spectrometry-based proteomics techniques and their application in ovarian cancer research
journal, October 2018
- Swiatly, Agata; Plewa, Szymon; Matysiak, Jan
- Journal of Ovarian Research, Vol. 11, Issue 1
Highly-accurate metabolomic detection of early-stage ovarian cancer
journal, November 2015
- Gaul, David A.; Mezencev, Roman; Long, Tran Q.
- Scientific Reports, Vol. 5, Issue 1
20(S)-Rg3 blocked epithelial-mesenchymal transition through DNMT3A/miR-145/FSCN1 in ovarian cancer
journal, June 2017
- Li, Jie; Lu, Jiaojiao; Ye, Zhongxue
- Oncotarget, Vol. 8, Issue 32
miR-30d Blocked Transforming Growth Factor β1–Induced Epithelial-Mesenchymal Transition by Targeting Snail in Ovarian Cancer Cells
journal, November 2015
- Ye, Zhongxue; Zhao, Le; Li, Jie
- International Journal of Gynecologic Cancer, Vol. 25, Issue 9
Expression and clinical significance of WWOX, Elf5, Snail1 and EMT related factors in epithelial ovarian cancer
journal, December 2019
- Hu, Yakun; Yan, Yuchen; Xu, Yang
- Oncology Letters
Quantitative Profiling of Single Formalin Fixed Tumour Sections: proteomics for translational research
journal, October 2016
- Hughes, Christopher S.; McConechy, Melissa K.; Cochrane, Dawn R.
- Scientific Reports, Vol. 6, Issue 1