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Title: Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action

Authors:
 [1];  [1];  [1];  [2];  [1];  [3];  [3];  [2];  [1]
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  1. Georgia State Univ., Atlanta, GA (United States)
  2. Brookhaven National Lab. (BNL), Upton, NY (United States)
  3. Kansai Univ., Osaka (Japan)
Publication Date:
Research Org.:
Argonne National Laboratory (ANL), Argonne, IL (United States); Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1168512
Alternate Identifier(s):
OSTI ID: 1201330
Report Number(s):
BNL-107771-2015-JA
Journal ID: ISSN 2041-1723; ncomms6935
Grant/Contract Number:  
SC00112704; AC02-98CH10886; W-31-109-ENG-38; AC02-06CH11357
Resource Type:
Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 6; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
ENGLISH
Subject:
59 BASIC BIOLOGICAL SCIENCES; chemical sciences; biochemistry; chemical biology; physical chemistry

Citation Formats

Huo, Lu, Davis, Ian, Liu, Fange, Andi, Babak, Esaki, Shingo, Iwaki, Hiroaki, Hasegawa, Yoshie, Orville, Allen M., and Liu, Aimin. Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action. United States: N. p., 2015. Web. doi:10.1038/ncomms6935.
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Huo, Lu, Davis, Ian, Liu, Fange, Andi, Babak, Esaki, Shingo, Iwaki, Hiroaki, Hasegawa, Yoshie, Orville, Allen M., & Liu, Aimin. Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action. United States. https://doi.org/10.1038/ncomms6935
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Huo, Lu, Davis, Ian, Liu, Fange, Andi, Babak, Esaki, Shingo, Iwaki, Hiroaki, Hasegawa, Yoshie, Orville, Allen M., and Liu, Aimin. Wed . "Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action". United States. https://doi.org/10.1038/ncomms6935. https://www.osti.gov/servlets/purl/1168512.
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@article{osti_1168512,
title = {Crystallographic and spectroscopic snapshots reveal a dehydrogenase in action},
author = {Huo, Lu and Davis, Ian and Liu, Fange and Andi, Babak and Esaki, Shingo and Iwaki, Hiroaki and Hasegawa, Yoshie and Orville, Allen M. and Liu, Aimin},
abstractNote = {},
doi = {10.1038/ncomms6935},
journal = {Nature Communications},
number = ,
volume = 6,
place = {United States},
year = {Wed Jan 07 00:00:00 EST 2015},
month = {Wed Jan 07 00:00:00 EST 2015}
}
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https://doi.org/10.1038/ncomms6935
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Works referenced in this record:

Alternative respiratory pathways of Escherichia coli: energetics and transcriptional regulation in response to electron acceptors
journal, July 1997

Capture of an intermediate in the catalytic cycle of L-aspartate- -semialdehyde dehydrogenase
journal, October 2003

  • Blanco, J.; Moore, R. A.; Viola, R. E.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 22
  • DOI: 10.1073/pnas.1634958100

Detection of Transient Intermediates in the Metal-Dependent Nonoxidative Decarboxylation Catalyzed by α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase
journal, August 2007

  • Li, Tingfeng; Ma, John K.; Hosler, Jonathan P.
  • Journal of the American Chemical Society, Vol. 129, Issue 30
  • DOI: 10.1021/ja073648l

Structural Basis for a Cofactor-dependent Oxidation Protection and Catalysis of Cyanobacterial Succinic Semialdehyde Dehydrogenase
journal, April 2013

Mitochondrial function and dysfunction in the cell: its relevance to aging and aging-related disease
journal, November 2002

Identification of a catalytically essential nucleophilic residue in sheep liver cytoplasmic aldehyde dehydrogenase
journal, April 1991

  • Kitson, T. M.; Hill, J. P.; Midwinter, G. G.
  • Biochemical Journal, Vol. 275, Issue 1
  • DOI: 10.1042/bj2750207

Endogenous kynurenines as targets for drug discovery and development
journal, August 2002

  • Stone, Trevor W.; Darlington, L. Gail
  • Nature Reviews Drug Discovery, Vol. 1, Issue 8
  • DOI: 10.1038/nrd870

Capture of an intermediate in the catalytic cycle of L-aspartate- -semialdehyde dehydrogenase
journal, October 2003

  • Blanco, J.; Moore, R. A.; Viola, R. E.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 22
  • DOI: 10.1073/pnas.1634958100

Detection of Transient Intermediates in the Metal-Dependent Nonoxidative Decarboxylation Catalyzed by α-Amino-β-Carboxymuconate-ε-Semialdehyde Decarboxylase
journal, August 2007

  • Li, Tingfeng; Ma, John K.; Hosler, Jonathan P.
  • Journal of the American Chemical Society, Vol. 129, Issue 30
  • DOI: 10.1021/ja073648l

The kynurenine pathway of tryptophan degradation as a drug target
journal, February 2004

The kynurenine pathway of tryptophan degradation as a drug target
journal, February 2004

A novel degradative pathway of 2-nitrobenzoate via 3-hydroxyanthranilate in Pseudomonas fluorescens strain KU-7
journal, September 2000

Active site of human liver aldehyde dehydrogenase
journal, September 1987

  • Abriola, Darryl P.; Fields, Robert; Stein, Stanley
  • Biochemistry, Vol. 26, Issue 18
  • DOI: 10.1021/bi00392a015

Understanding the role of tryptophan and serotonin metabolism in gastrointestinal function
journal, December 2009

Spontaneous α-N-6-Phosphogluconoylation of a “His Tag” inEscherichia coli:The Cause of Extra Mass of 258 or 178 Da in Fusion Proteins
journal, February 1999

  • Geoghegan, Kieran F.; Dixon, Henry B. F.; Rosner, Philip J.
  • Analytical Biochemistry, Vol. 267, Issue 1
  • DOI: 10.1006/abio.1998.2990

Quinolinic acid in cerebrospinal fluid and serum in HIV-1 Infection: Relationship to clinical and neurological status
journal, February 1991

  • Heyes, Melvyn P.; Brew, Bruce J.; Martin, Alex
  • Annals of Neurology, Vol. 29, Issue 2
  • DOI: 10.1002/ana.410290215

The Pyridine Ring of NAD Is Formed by a Nonenzymatic Pericyclic Reaction
journal, January 2005

  • Colabroy, Keri L.; Begley, Tadhg P.
  • Journal of the American Chemical Society, Vol. 127, Issue 3
  • DOI: 10.1021/ja0446395

Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion
journal, May 1997

Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques
journal, July 1998

Purification, Characterization, and Sequence Analysis of 2-Aminomuconic 6-Semialdehyde Dehydrogenase from Pseudomonas pseudoalcaligenes JS45
journal, September 1998

Kynurenine pathway in major depression: Evidence of impaired neuroprotection
journal, February 2007

  • Myint, Aye-Mu; Kim, Yong Ku; Verkerk, Robert
  • Journal of Affective Disorders, Vol. 98, Issue 1-2
  • DOI: 10.1016/j.jad.2006.07.013

Aldehyde dehydrogenases: Widespread structural and functional diversity within a shared framework
journal, November 1993

The First Crystal Structure of a Thioacylenzyme Intermediate in the ALDH Family:  New Coenzyme Conformation and Relevance to Catalysis †
journal, March 2006

  • D'Ambrosio, Katia; Pailot, Arnaud; Talfournier, François
  • Biochemistry, Vol. 45, Issue 9
  • DOI: 10.1021/bi0515117

Correlated single-crystal electronic absorption spectroscopy and X-ray crystallography at NSLS beamline X26-C
journal, March 2011

  • Orville, Allen M.; Buono, Richard; Cowan, Matt
  • Journal of Synchrotron Radiation, Vol. 18, Issue 3
  • DOI: 10.1107/S0909049511006315

Automated detection and centring of cryocooled protein crystals
journal, October 2006

  • Pothineni, Sudhir Babu; Strutz, Tilo; Lamzin, Victor S.
  • Acta Crystallographica Section D Biological Crystallography, Vol. 62, Issue 11
  • DOI: 10.1107/s0907444906031672

Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex
journal, January 1998

Crystallographic evidence for active-site dynamics in the hydrolytic aldehyde dehydrogenases. Implications for the deacylation step of the catalyzed reaction
journal, May 2011

  • Muñoz-Clares, Rosario A.; González-Segura, Lilian; Díaz-Sánchez, Ángel G.
  • Chemico-Biological Interactions, Vol. 191, Issue 1-3
  • DOI: 10.1016/j.cbi.2010.12.024

Coot model-building tools for molecular graphics
journal, November 2004

  • Emsley, Paul; Cowtan, Kevin
  • Acta Crystallographica Section D Biological Crystallography, Vol. 60, Issue 12, p. 2126-2132
  • DOI: 10.1107/S0907444904019158

Coenzyme Isomerization Is Integral to Catalysis in Aldehyde Dehydrogenase † , ‡
journal, June 2003

  • Perez-Miller, Samantha J.; Hurley, Thomas D.
  • Biochemistry, Vol. 42, Issue 23
  • DOI: 10.1021/bi034182w

Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques
journal, July 1998

Kynurenine pathway in major depression: Evidence of impaired neuroprotection
journal, February 2007

  • Myint, Aye-Mu; Kim, Yong Ku; Verkerk, Robert
  • Journal of Affective Disorders, Vol. 98, Issue 1-2
  • DOI: 10.1016/j.jad.2006.07.013

Sheep liver cytosolic aldehyde dehydrogenase: the structure reveals the basis for the retinal specificity of class 1 aldehyde dehydrogenases
journal, December 1998

PHENIX: a comprehensive Python-based system for macromolecular structure solution
journal, January 2010

  • Adams, Paul D.; Afonine, Pavel V.; Bunkóczi, Gábor
  • Acta Crystallographica Section D Biological Crystallography, Vol. 66, Issue 2, p. 213-221
  • DOI: 10.1107/S0907444909052925

The First Crystal Structure of a Thioacylenzyme Intermediate in the ALDH Family:  New Coenzyme Conformation and Relevance to Catalysis
journal, August 2007

  • D'Ambrosio, Katia; Pailot, Arnaud; Talfournier, Francois
  • Biochemistry, Vol. 46, Issue 35
  • DOI: 10.1021/bi701283c

Quinolinic acid in cerebrospinal fluid and serum in HIV-1 Infection: Relationship to clinical and neurological status
journal, February 1991

  • Heyes, Melvyn P.; Brew, Bruce J.; Martin, Alex
  • Annals of Neurology, Vol. 29, Issue 2
  • DOI: 10.1002/ana.410290215

Kinetic and Spectroscopic Characterization of ACMSD from Pseudomonas fluorescens Reveals a Pentacoordinate Mononuclear Metallocofactor
journal, September 2005

  • Li, Tingfeng; Walker, Antoinette L.; Iwaki, Hiroaki
  • Journal of the American Chemical Society, Vol. 127, Issue 35
  • DOI: 10.1021/ja0532234

Kinetic and Spectroscopic Characterization of ACMSD from Pseudomonas fluorescens Reveals a Pentacoordinate Mononuclear Metallocofactor
journal, September 2005

  • Li, Tingfeng; Walker, Antoinette L.; Iwaki, Hiroaki
  • Journal of the American Chemical Society, Vol. 127, Issue 35
  • DOI: 10.1021/ja0532234

Kynurenine pathway abnormalities in Parkinson's disease
journal, September 1992

Relationships within the aldehyde dehydrogenase extended family
journal, January 1999

  • Perozich, John; Nicholas, Hugh; Wang, Bi-Cheng
  • Protein Science, Vol. 8, Issue 1
  • DOI: 10.1110/ps.8.1.137

Investigation of the Active Site Cysteine Residue of Rat Liver Mitochondrial Aldehyde Dehydrogenase by Site-Directed Mutagenesis
journal, February 1995

  • Farres, Jaume; Wang, Thomas T. Y.; Cunningham, Suzanne J.
  • Biochemistry, Vol. 34, Issue 8
  • DOI: 10.1021/bi00008a025

Crystallographic evidence for active-site dynamics in the hydrolytic aldehyde dehydrogenases. Implications for the deacylation step of the catalyzed reaction
journal, May 2011

  • Muñoz-Clares, Rosario A.; González-Segura, Lilian; Díaz-Sánchez, Ángel G.
  • Chemico-Biological Interactions, Vol. 191, Issue 1-3
  • DOI: 10.1016/j.cbi.2010.12.024

Coenzyme Isomerization Is Integral to Catalysis in Aldehyde Dehydrogenase † , ‡
journal, June 2003

  • Perez-Miller, Samantha J.; Hurley, Thomas D.
  • Biochemistry, Vol. 42, Issue 23
  • DOI: 10.1021/bi034182w

Endogenous kynurenines as targets for drug discovery and development
journal, August 2002

  • Stone, Trevor W.; Darlington, L. Gail
  • Nature Reviews Drug Discovery, Vol. 1, Issue 8
  • DOI: 10.1038/nrd870

Identification of a catalytically essential nucleophilic residue in sheep liver cytoplasmic aldehyde dehydrogenase
journal, April 1991

  • Kitson, T. M.; Hill, J. P.; Midwinter, G. G.
  • Biochemical Journal, Vol. 275, Issue 1
  • DOI: 10.1042/bj2750207

Aldehyde dehydrogenases: Widespread structural and functional diversity within a shared framework
journal, November 1993

Quinolinic Acid in the Pathogenesis of Alzheimer's Disease
book, January 2003

  • Guillemin, Gilles J.; Williams, Kieran R.; Smith, Danielle G.
  • Advances in Experimental Medicine and Biology
  • DOI: 10.1007/978-1-4615-0135-0_19

Chronic exposure of human neurons to quinolinic acid results in neuronal changes consistent with AIDS dementia complex
journal, January 1998

Active site of human liver aldehyde dehydrogenase
journal, September 1987

  • Abriola, Darryl P.; Fields, Robert; Stein, Stanley
  • Biochemistry, Vol. 26, Issue 18
  • DOI: 10.1021/bi00392a015

3-Hydroxykynurenine and Quinolinate: Pathogenic Synergism in Early Grade Huntington’s Disease?
book, January 2003

A novel degradative pathway of 2-nitrobenzoate via 3-hydroxyanthranilate in Pseudomonas fluorescens strain KU-7
journal, September 2000

Studies on the Metabolism of the Benzene Ring of Tryptophan in Mammalian Tissues
journal, February 1965

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    Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism
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