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Title: One-Step Generation of Multifunctional Polyelectrolyte Microcapsules via Nanoscale Interfacial Complexation in Emulsion (NICE)

Polyelectrolyte microcapsules represent versatile stimuli-responsive structures that enable the encapsulation, protection, and release of active agents. Their conventional preparation methods, however, tend to be time-consuming, yield low encapsulation efficiency, and seldom allow for the dual incorporation of hydrophilic and hydrophobic materials, limiting their widespread utilization. In this work, we present a method to fabricate stimuli-responsive polyelectrolyte microcapsules in one step based on nanoscale interfacial complexation in emulsions (NICE) followed by spontaneous droplet hatching. NICE microcapsules can incorporate both hydrophilic and hydrophobic materials and also can be induced to trigger the release of encapsulated materials by changes in the solution pH or ionic strength. We also show that NICE microcapsules can be functionalized with nanomaterials to exhibit useful functionality, such as response to a magnetic field and disassembly in response to light. NICE represents a potentially transformative method to prepare multifunctional nanoengineered polyelectrolyte microcapsules for various applications such as drug delivery and cell mimicry.
Authors:
 [1] ;  [2] ;  [3] ;  [3] ;  [4] ;  [1] ;  [3]
  1. Univ. of Pennsylvania, Philadelphia, PA (United States); Pohang Univ. of Science and Technology (POSTECH) (Korea, Republic of)
  2. Univ. of Pennsylvania, Philadelphia, PA (United States); Sungkyunkwan Univ., Suwon (Republic of Korea)
  3. Univ. of Pennsylvania, Philadelphia, PA (United States)
  4. School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 440-746, Republic of Korea
Publication Date:
Grant/Contract Number:
sc0007063
Type:
Published Article
Journal Name:
ACS Nano
Additional Journal Information:
Journal Volume: 9; Journal Issue: 8; Journal ID: ISSN 1936-0851
Publisher:
American Chemical Society (ACS)
Research Org:
Univ. of Pennsylvania, Philadelphia, PA (United States)
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY; polyelectrolyte complexes; polyelectrolyte microcapsule; stimuli-responsive materials; triggered release
OSTI Identifier:
1198708
Alternate Identifier(s):
OSTI ID: 1454698