Lipopolysaccharide induced MAP kinase activation in RAW 264.7 cells attenuated by cerium oxide nanoparticles

Selvaraj, Vellaisamy; Nepal, Niraj; Rogers, Steven; Manne, Nandini D. P. K.; Arvapalli, Ravikumar; Rice, Kevin M.; Asano, Shinichi; Fankenhanel, Erin; Ma, J. Y.; Shokuhfar, Tolou; Maheshwari, Mani; Blough, Eric R.

doi:10.1016/j.dib.2015.04.022

Title: Lipopolysaccharide induced MAP kinase activation in RAW 264.7 cells attenuated by cerium oxide nanoparticles

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Abstract

High mortality rates are associated with the life threatening disease of sepsis. Improvements in septic patient survivability have failed to materialize with currently available treatments. This article represents data regarding a study published in biomaterials (Vellaisamy et al., Biomaterials, 2015, in press). with the purpose of evaluating whether severe sepsis mortality and associated hepatic dysfunction induced by lipopolysaccharide (LPS) can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the method and processing of raw data related to our study publish in Biomaterials and Data in Brief (Vellaisamy et al., Biomaterials, 2015, in press; Vellaisamy et al., Data in Brief, 2015, in press.). The data contained in this article evaluates the contribution of MAPK signaling in LPS induced sepsis. Macrophage cells (RAW 264.7) were treated with a range of cerium oxide nanoparticle concentration in the presence and absence of LPS. Immunoblotting was performed on the cell lysates to evaluate the effect of cerium oxide nanoparticle treatment on LPS induced changes in Mitogen Activated Protein Kinases (MAPK) p-38, ERK 1/2, and SAPK/JNK phosphorylation.

Authors:: Selvaraj, Vellaisamy; Nepal, Niraj; Rogers, Steven; Manne, Nandini D. P. K.; Arvapalli, Ravikumar; Rice, Kevin M.; Asano, Shinichi; Fankenhanel, Erin; Ma, J. Y.; Shokuhfar, Tolou; Maheshwari, Mani; Blough, Eric R.

Publication Date:: Tue Sep 01 00:00:00 EDT 2015

Research Org.:: Marshall Univ., Huntington, WV (United States)

Sponsoring Org.:: USDOE Office of Science (SC)

OSTI Identifier:: 1198694

Alternate Identifier(s):: OSTI ID: 1629755

Grant/Contract Number:: PS02-09ER-01; SC0008104

Resource Type:: Published Article

Journal Name:: Data in Brief

Additional Journal Information:: Journal Name: Data in Brief Journal Volume: 4 Journal Issue: C; Journal ID: ISSN 2352-3409

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES; Sepsis; LPS; MAPK; Raw 264.7 cells

Citation Formats


                    Selvaraj, Vellaisamy, Nepal, Niraj, Rogers, Steven, Manne, Nandini D. P. K., Arvapalli, Ravikumar, Rice, Kevin M., Asano, Shinichi, Fankenhanel, Erin, Ma, J. Y., Shokuhfar, Tolou, Maheshwari, Mani, and Blough, Eric R. Lipopolysaccharide induced MAP kinase activation in RAW 264.7 cells attenuated by cerium oxide nanoparticles.  United States: N. p., 2015. 
Web.  doi:10.1016/j.dib.2015.04.022.

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                    Selvaraj, Vellaisamy, Nepal, Niraj, Rogers, Steven, Manne, Nandini D. P. K., Arvapalli, Ravikumar, Rice, Kevin M., Asano, Shinichi, Fankenhanel, Erin, Ma, J. Y., Shokuhfar, Tolou, Maheshwari, Mani, & Blough, Eric R. Lipopolysaccharide induced MAP kinase activation in RAW 264.7 cells attenuated by cerium oxide nanoparticles.  United States.  https://doi.org/10.1016/j.dib.2015.04.022

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                    Selvaraj, Vellaisamy, Nepal, Niraj, Rogers, Steven, Manne, Nandini D. P. K., Arvapalli, Ravikumar, Rice, Kevin M., Asano, Shinichi, Fankenhanel, Erin, Ma, J. Y., Shokuhfar, Tolou, Maheshwari, Mani, and Blough, Eric R. Tue .  
"Lipopolysaccharide induced MAP kinase activation in RAW 264.7 cells attenuated by cerium oxide nanoparticles".  United States.  https://doi.org/10.1016/j.dib.2015.04.022.

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@article{osti_1198694,

  title        = {Lipopolysaccharide induced MAP kinase activation in RAW 264.7 cells attenuated by cerium oxide nanoparticles},

  author       = {Selvaraj, Vellaisamy and Nepal, Niraj and Rogers, Steven and Manne, Nandini D. P. K. and Arvapalli, Ravikumar and Rice, Kevin M. and Asano, Shinichi and Fankenhanel, Erin and Ma, J. Y. and Shokuhfar, Tolou and Maheshwari, Mani and Blough, Eric R.},

  abstractNote = {High mortality rates are associated with the life threatening disease of sepsis. Improvements in septic patient survivability have failed to materialize with currently available treatments. This article represents data regarding a study published in biomaterials (Vellaisamy et al., Biomaterials, 2015, in press). with the purpose of evaluating whether severe sepsis mortality and associated hepatic dysfunction induced by lipopolysaccharide (LPS) can be prevented by cerium oxide nanoparticles (CeO2NPs) treatment in male Sprague Dawley rats. Here we provide the information about the method and processing of raw data related to our study publish in Biomaterials and Data in Brief (Vellaisamy et al., Biomaterials, 2015, in press; Vellaisamy et al., Data in Brief, 2015, in press.). The data contained in this article evaluates the contribution of MAPK signaling in LPS induced sepsis. Macrophage cells (RAW 264.7) were treated with a range of cerium oxide nanoparticle concentration in the presence and absence of LPS. Immunoblotting was performed on the cell lysates to evaluate the effect of cerium oxide nanoparticle treatment on LPS induced changes in Mitogen Activated Protein Kinases (MAPK) p-38, ERK 1/2, and SAPK/JNK phosphorylation.},

  doi          = {10.1016/j.dib.2015.04.022},

  journal      = {Data in Brief},

  number       = C,

  volume       = 4,

  place        = {United States},

  year         = {Tue Sep 01 00:00:00 EDT 2015},

  month        = {Tue Sep 01 00:00:00 EDT 2015}

}

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