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Title: FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas

Abstract

Purpose . The aim of this study was to prospectively evaluate whether FDG-PET allows an accurate assessment of histopathologic response to neoadjuvant treatment in adult patients with primary bone sarcomas. Methods . Twelve consecutive patients with resectable, primary high grade bone sarcomas were enrolled prospectively. FDG-PET/CT imaging was performed prior to the initiation and after completion of neoadjuvant treatment. Imaging findings were correlated with histopathologic response. Results . Histopathologic responders showed significantly more pronounced decreases in tumor FDG-SUVmax from baseline to late follow up than non-responders ( 64 ± 19 % versus 29 ± 30 %, resp.; P = .03 ). Using a 60% decrease in tumor FDG-uptake as a threshold for metabolic response correctly classified 3 of 4 histopathologic responders and 7 of 8 histopathologic non-responders as metabolic responders and non-responders, respectively (sensitivity, 75%; specificity, 88%). Conclusion . These results suggest that changes in FDG-SUVmax at the end of neoadjuvant treatment can identify histopathologic responders and non-responders in adult primary bone sarcoma patients.

Authors:
 [1];  [1];  [2];  [3];  [4];  [1];  [5];  [1];  [6];  [7]
  1. Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1782, USA
  2. Division of Medical Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1782, USA
  3. Department of Orthopedic Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1782, USA
  4. Department of Radiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1782, USA
  5. Department of Pathology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1782, USA
  6. Abteilung Nuklearmedizin, University of Freiburg, 79106 Freiburg, Germany
  7. Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1782, USA, Division of Surgical Oncology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1782, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1198465
Grant/Contract Number:  
FG02-06ER64249
Resource Type:
Published Article
Journal Name:
Sarcoma
Additional Journal Information:
Journal Name: Sarcoma Journal Volume: 2010; Journal ID: ISSN 1357-714X
Publisher:
Hindawi Publishing Corporation
Country of Publication:
Country unknown/Code not available
Language:
English

Citation Formats

Benz, Matthias R., Czernin, Johannes, Tap, William D., Eckardt, Jeffrey J., Seeger, Leanne L., Allen-Auerbach, Martin S., Dry, Sarah M., Phelps, Michael E., Weber, Wolfgang A., and Eilber, Fritz C. FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas. Country unknown/Code not available: N. p., 2010. Web. doi:10.1155/2010/143540.
Benz, Matthias R., Czernin, Johannes, Tap, William D., Eckardt, Jeffrey J., Seeger, Leanne L., Allen-Auerbach, Martin S., Dry, Sarah M., Phelps, Michael E., Weber, Wolfgang A., & Eilber, Fritz C. FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas. Country unknown/Code not available. doi:10.1155/2010/143540.
Benz, Matthias R., Czernin, Johannes, Tap, William D., Eckardt, Jeffrey J., Seeger, Leanne L., Allen-Auerbach, Martin S., Dry, Sarah M., Phelps, Michael E., Weber, Wolfgang A., and Eilber, Fritz C. Fri . "FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas". Country unknown/Code not available. doi:10.1155/2010/143540.
@article{osti_1198465,
title = {FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas},
author = {Benz, Matthias R. and Czernin, Johannes and Tap, William D. and Eckardt, Jeffrey J. and Seeger, Leanne L. and Allen-Auerbach, Martin S. and Dry, Sarah M. and Phelps, Michael E. and Weber, Wolfgang A. and Eilber, Fritz C.},
abstractNote = {Purpose . The aim of this study was to prospectively evaluate whether FDG-PET allows an accurate assessment of histopathologic response to neoadjuvant treatment in adult patients with primary bone sarcomas. Methods . Twelve consecutive patients with resectable, primary high grade bone sarcomas were enrolled prospectively. FDG-PET/CT imaging was performed prior to the initiation and after completion of neoadjuvant treatment. Imaging findings were correlated with histopathologic response. Results . Histopathologic responders showed significantly more pronounced decreases in tumor FDG-SUVmax from baseline to late follow up than non-responders ( 64 ± 19 % versus 29 ± 30 %, resp.; P = .03 ). Using a 60% decrease in tumor FDG-uptake as a threshold for metabolic response correctly classified 3 of 4 histopathologic responders and 7 of 8 histopathologic non-responders as metabolic responders and non-responders, respectively (sensitivity, 75%; specificity, 88%). Conclusion . These results suggest that changes in FDG-SUVmax at the end of neoadjuvant treatment can identify histopathologic responders and non-responders in adult primary bone sarcoma patients.},
doi = {10.1155/2010/143540},
journal = {Sarcoma},
number = ,
volume = 2010,
place = {Country unknown/Code not available},
year = {2010},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1155/2010/143540

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