Ion Selectivity Mechanism in a Bacterial Pentameric Ligand-Gated Ion Channel

Fritsch, Sebastian; Ivanov, Ivaylo; Wang, Hailong; Cheng, Xiaolin

doi:10.1016/j.bpj.2010.11.077

Title: Ion Selectivity Mechanism in a Bacterial Pentameric Ligand-Gated Ion Channel

Authors:: Fritsch, Sebastian; Ivanov, Ivaylo; Wang, Hailong; Cheng, Xiaolin

Publication Date:: Sat Jan 01 00:00:00 EST 2011

Sponsoring Org.:: USDOE

OSTI Identifier:: 1198420

Grant/Contract Number:: FWP ERKJE84

Resource Type:: Published Article

Journal Name:: Biophysical Journal

Additional Journal Information:: Journal Name: Biophysical Journal Journal Volume: 100 Journal Issue: 2; Journal ID: ISSN 0006-3495

Publisher:: Elsevier

Country of Publication:: United States

Language:: English

Citation Formats


                    Fritsch, Sebastian, Ivanov, Ivaylo, Wang, Hailong, and Cheng, Xiaolin. Ion Selectivity Mechanism in a Bacterial Pentameric Ligand-Gated Ion Channel.  United States: N. p., 2011. 
Web.  doi:10.1016/j.bpj.2010.11.077.

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                    Fritsch, Sebastian, Ivanov, Ivaylo, Wang, Hailong, & Cheng, Xiaolin. Ion Selectivity Mechanism in a Bacterial Pentameric Ligand-Gated Ion Channel.  United States.  https://doi.org/10.1016/j.bpj.2010.11.077

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                    Fritsch, Sebastian, Ivanov, Ivaylo, Wang, Hailong, and Cheng, Xiaolin. Sat .  
"Ion Selectivity Mechanism in a Bacterial Pentameric Ligand-Gated Ion Channel".  United States.  https://doi.org/10.1016/j.bpj.2010.11.077.

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@article{osti_1198420,

  title        = {Ion Selectivity Mechanism in a Bacterial Pentameric Ligand-Gated Ion Channel},

  author       = {Fritsch, Sebastian and Ivanov, Ivaylo and Wang, Hailong and Cheng, Xiaolin},

  abstractNote = {},

  doi          = {10.1016/j.bpj.2010.11.077},

  journal      = {Biophysical Journal},

  number       = 2,

  volume       = 100,

  place        = {United States},

  year         = {Sat Jan 01 00:00:00 EST 2011},

  month        = {Sat Jan 01 00:00:00 EST 2011}

}

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Title: Ion Selectivity Mechanism in a Bacterial Pentameric Ligand-Gated Ion Channel

Citation Formats

A stepwise mechanism for acetylcholine receptor channel gating journal, April 2007

Detection and trapping of intermediate states priming nicotinic receptor channel opening journal, April 2009

Electrostatics of nanosystems: Application to microtubules and the ribosome journal, August 2001

Pore conformations and gating mechanism of a Cys-loop receptor journal, October 2005

X-ray structure of a prokaryotic pentameric ligand-gated ion channel journal, March 2008

Nonphysical sampling distributions in Monte Carlo free-energy estimation: Umbrella sampling journal, February 1977

On the Origin of Ion Selectivity in the Cys-Loop Receptor Family journal, September 2009

Nicotinic Receptors at the Amino Acid Level journal, April 2000

Ligand-gated ion channels: mechanisms underlying ion selectivity journal, October 2004

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue journal, March 2010

Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors journal, February 2010

Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems journal, June 1993

A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor journal, June 2006

Rational Understanding of Nicotinic Receptors Drug Binding journal, February 2004

Scalable molecular dynamics with NAMD journal, January 2005

HOLE: A program for the analysis of the pore dimensions of ion channel structural models journal, December 1996

Ion Conduction in Ligand-Gated Ion Channels: Brownian Dynamics Studies of Four Recent Crystal Structures journal, February 2010

THE weighted histogram analysis method for free-energy calculations on biomolecules. I. The method journal, October 1992

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes journal, March 1977

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family journal, December 2006

Barriers to Ion Translocation in Cationic and Anionic Receptors from the Cys-Loop Family journal, June 2007

An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance journal, October 2008

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues journal, February 2010

Reversible multiple time scale molecular dynamics journal, August 1992

PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations journal, July 2004

Recent advances in Cys-loop receptor structure and function journal, March 2006

Emerging structure of the Nicotinic Acetylcholine receptors journal, February 2002

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches journal, August 1981

Tests of Continuum Theories as Models of Ion Channels. I. Poisson−Boltzmann Theory versus Brownian Dynamics journal, May 2000

Energetics of ion conduction through the gramicidin channel journal, December 2003

Mutational Analysis of the Charge Selectivity Filter of the α7 Nicotinic Acetylcholine Receptor journal, April 1999

Role of acetylcholine receptor domains in ion selectivity journal, July 2009

Control of Cation Permeation through the Nicotinic Receptor Channel journal, January 2008

Intrinsic Ion Selectivity of Narrow Hydrophobic Pores journal, May 2009

M2 Pore Mutations Convert the Glycine Receptor Channel from Being Anion- to Cation-Selective journal, July 2000

Structure and gating mechanism of the acetylcholine receptor pore journal, June 2003

Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution journal, March 2005

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance journal, October 1988

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel journal, November 2008

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation journal, November 2008

VMD: Visual molecular dynamics journal, February 1996

Conversion of the Ion Selectivity of the 5-HT3AReceptor from Cationic to Anionic Reveals a Conserved Feature of the Ligand-gated Ion Channel Superfamily journal, April 2001

A stepwise mechanism for acetylcholine receptor channel gating
journal, April 2007

Detection and trapping of intermediate states priming nicotinic receptor channel opening
journal, April 2009

Electrostatics of nanosystems: Application to microtubules and the ribosome
journal, August 2001

Pore conformations and gating mechanism of a Cys-loop receptor
journal, October 2005

X-ray structure of a prokaryotic pentameric ligand-gated ion channel
journal, March 2008

Nonphysical sampling distributions in Monte Carlo free-energy estimation: Umbrella sampling
journal, February 1977

On the Origin of Ion Selectivity in the Cys-Loop Receptor Family
journal, September 2009

Nicotinic Receptors at the Amino Acid Level
journal, April 2000

Ligand-gated ion channels: mechanisms underlying ion selectivity
journal, October 2004

One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue
journal, March 2010

Novel structural determinants of single channel conductance and ion selectivity in 5-hydroxytryptamine type 3 and nicotinic acetylcholine receptors
journal, February 2010

Particle mesh Ewald: An N ⋅log( N ) method for Ewald sums in large systems
journal, June 1993

A hydrophobic gate in an ion channel: the closed state of the nicotinic acetylcholine receptor
journal, June 2006

Rational Understanding of Nicotinic Receptors Drug Binding
journal, February 2004

Scalable molecular dynamics with NAMD
journal, January 2005

HOLE: A program for the analysis of the pore dimensions of ion channel structural models
journal, December 1996

Ion Conduction in Ligand-Gated Ion Channels: Brownian Dynamics Studies of Four Recent Crystal Structures
journal, February 2010

THE weighted histogram analysis method for free-energy calculations on biomolecules. I. The method
journal, October 1992

Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n-alkanes
journal, March 1977

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family
journal, December 2006

Barriers to Ion Translocation in Cationic and Anionic Receptors from the Cys-Loop Family
journal, June 2007

An Ion Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance
journal, October 2008

Atomic structure and dynamics of pentameric ligand-gated ion channels: new insight from bacterial homologues
journal, February 2010

Reversible multiple time scale molecular dynamics
journal, August 1992

PDB2PQR: an automated pipeline for the setup of Poisson-Boltzmann electrostatics calculations
journal, July 2004

Recent advances in Cys-loop receptor structure and function
journal, March 2006

Emerging structure of the Nicotinic Acetylcholine receptors
journal, February 2002

Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
journal, August 1981

Tests of Continuum Theories as Models of Ion Channels. I. Poisson−Boltzmann Theory versus Brownian Dynamics
journal, May 2000

Energetics of ion conduction through the gramicidin channel
journal, December 2003

Mutational Analysis of the Charge Selectivity Filter of the α7 Nicotinic Acetylcholine Receptor
journal, April 1999

Role of acetylcholine receptor domains in ion selectivity
journal, July 2009

Control of Cation Permeation through the Nicotinic Receptor Channel
journal, January 2008

Intrinsic Ion Selectivity of Narrow Hydrophobic Pores
journal, May 2009

M2 Pore Mutations Convert the Glycine Receptor Channel from Being Anion- to Cation-Selective
journal, July 2000

Structure and gating mechanism of the acetylcholine receptor pore
journal, June 2003

Refined Structure of the Nicotinic Acetylcholine Receptor at 4Å Resolution
journal, March 2005

Rings of negatively charged amino acids determine the acetylcholine receptor channel conductance
journal, October 1988

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel
journal, November 2008

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation
journal, November 2008

VMD: Visual molecular dynamics
journal, February 1996

Conversion of the Ion Selectivity of the 5-HT3AReceptor from Cationic to Anionic Reveals a Conserved Feature of the Ligand-gated Ion Channel Superfamily
journal, April 2001