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Title: Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea

Abstract

Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by their strict dependence on the process of methanogenesis for energy conservation. Among the archaea, they are also the only known group synthesizing proteins containing selenocysteine or pyrrolysine. All but one of the known archaeal pyrrolysine-containing and all but two of the confirmed archaeal selenocysteine-containing protein are involved in methanogenesis. Synthesis of these proteins proceeds through suppression of translational stop codons but otherwise the two systems are fundamentally different. This paper highlights these differences and summarizes the recent developments in selenocysteine- and pyrrolysine-related research on archaea and aims to put this knowledge into the context of their unique energy metabolism.

Authors:
 [1];  [2]
  1. Institut für Molekulare Biowissenschaften, Molekulare Mikrobiologie & Bioenergetik, Johann Wolfgang Goethe-Universität, Max-von-Laue-Str. 9, 60438 Frankfurt am Main, Germany
  2. Department of Microbiology, The Ohio State University, 376 Biological Sciences Building 484 West 12th Avenue Columbus, OH 43210-1292, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1198387
Grant/Contract Number:  
FG0202-91ER200042
Resource Type:
Published Article
Journal Name:
Archaea
Additional Journal Information:
Journal Name: Archaea Journal Volume: 2010; Journal ID: ISSN 1472-3646
Publisher:
Hindawi Publishing Corporation
Country of Publication:
United States
Language:
English

Citation Formats

Rother, Michael, and Krzycki, Joseph A. Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea. United States: N. p., 2010. Web. doi:10.1155/2010/453642.
Rother, Michael, & Krzycki, Joseph A. Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea. United States. doi:10.1155/2010/453642.
Rother, Michael, and Krzycki, Joseph A. Fri . "Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea". United States. doi:10.1155/2010/453642.
@article{osti_1198387,
title = {Selenocysteine, Pyrrolysine, and the Unique Energy Metabolism of Methanogenic Archaea},
author = {Rother, Michael and Krzycki, Joseph A.},
abstractNote = {Methanogenic archaea are a group of strictly anaerobic microorganisms characterized by their strict dependence on the process of methanogenesis for energy conservation. Among the archaea, they are also the only known group synthesizing proteins containing selenocysteine or pyrrolysine. All but one of the known archaeal pyrrolysine-containing and all but two of the confirmed archaeal selenocysteine-containing protein are involved in methanogenesis. Synthesis of these proteins proceeds through suppression of translational stop codons but otherwise the two systems are fundamentally different. This paper highlights these differences and summarizes the recent developments in selenocysteine- and pyrrolysine-related research on archaea and aims to put this knowledge into the context of their unique energy metabolism.},
doi = {10.1155/2010/453642},
journal = {Archaea},
number = ,
volume = 2010,
place = {United States},
year = {2010},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1155/2010/453642

Citation Metrics:
Cited by: 29 works
Citation information provided by
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