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Title: A Model Incorporating Some of the Mechanical and Biochemical Factors Underlying Clot Formation and Dissolution in Flowing Blood

Abstract

Multiple interacting mechanisms control the formation and dissolution of clots to maintain blood in a state of delicate balance. In addition to a myriad of biochemical reactions, rheological factors also play a crucial role in modulating the response of blood to external stimuli. To date, a comprehensive model for clot formation and dissolution, that takes into account the biochemical, medical and rheological factors, has not been put into place, the existing models emphasizing either one or the other of the factors. In this paper, after discussing the various biochemical, physiologic and rheological factors at some length, we develop a model for clot formation and dissolution that incorporates many of the relevant crucial factors that have a bearing on the problem. The model, though just a first step towards understanding a complex phenomenon, goes further than previous models in integrating the biochemical, physiologic and rheological factors that come into play.

Authors:
 [1];  [2];  [1]
  1. Department of Mechanical Engineering, Texas A & M University, College Station, TX 77843, USA
  2. Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1198219
Resource Type:
Published Article
Journal Name:
Journal of Theoretical Medicine
Additional Journal Information:
Journal Name: Journal of Theoretical Medicine Journal Volume: 5 Journal Issue: 3-4; Journal ID: ISSN 1027-3662
Publisher:
Hindawi Publishing Corporation
Country of Publication:
Country unknown/Code not available
Language:
English

Citation Formats

Anand, M., Rajagopal, K., and Rajagopal, K. R. A Model Incorporating Some of the Mechanical and Biochemical Factors Underlying Clot Formation and Dissolution in Flowing Blood. Country unknown/Code not available: N. p., 2003. Web. doi:10.1080/10273660412331317415.
Anand, M., Rajagopal, K., & Rajagopal, K. R. A Model Incorporating Some of the Mechanical and Biochemical Factors Underlying Clot Formation and Dissolution in Flowing Blood. Country unknown/Code not available. doi:10.1080/10273660412331317415.
Anand, M., Rajagopal, K., and Rajagopal, K. R. Wed . "A Model Incorporating Some of the Mechanical and Biochemical Factors Underlying Clot Formation and Dissolution in Flowing Blood". Country unknown/Code not available. doi:10.1080/10273660412331317415.
@article{osti_1198219,
title = {A Model Incorporating Some of the Mechanical and Biochemical Factors Underlying Clot Formation and Dissolution in Flowing Blood},
author = {Anand, M. and Rajagopal, K. and Rajagopal, K. R.},
abstractNote = {Multiple interacting mechanisms control the formation and dissolution of clots to maintain blood in a state of delicate balance. In addition to a myriad of biochemical reactions, rheological factors also play a crucial role in modulating the response of blood to external stimuli. To date, a comprehensive model for clot formation and dissolution, that takes into account the biochemical, medical and rheological factors, has not been put into place, the existing models emphasizing either one or the other of the factors. In this paper, after discussing the various biochemical, physiologic and rheological factors at some length, we develop a model for clot formation and dissolution that incorporates many of the relevant crucial factors that have a bearing on the problem. The model, though just a first step towards understanding a complex phenomenon, goes further than previous models in integrating the biochemical, physiologic and rheological factors that come into play.},
doi = {10.1080/10273660412331317415},
journal = {Journal of Theoretical Medicine},
number = 3-4,
volume = 5,
place = {Country unknown/Code not available},
year = {2003},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1080/10273660412331317415

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