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Title: Osteogenic Sarcoma of the Maxilla: Neutron Therapy for Unresectable Disease

Abstract

Purpose. To present a case study involving the use of fast neutron therapy to treat an extensive unresectable osteogenic sarcoma arising from the left maxilla. Patient. A 14-year-old male presented with a massive tumor producing severe distortion of his facial structures. He had already received six courses of chemotherapy, which had reduced his pain, but had not measurably reduced the tumor. Methods. The patient was treated with 66 MeV fast neutrons to a dose of 20.4 Gy in 13 fractions over 35 days. Results. CT assessments indicate gradually increasing calcification and noticeable reduction of soft-tissue disease in the frontal sinus, orbit and maxillary antrum.There has been some recontouring of the facial structures.The boy conducts an active life, has no pain, and feels well. He was 17 years old at the last follow-up. Discussion. Fast neutrons have a greater biological effectiveness than conventional photon beams. Their use has been associated with improved chance for local control of unresectable disease.This case illustrates their effectiveness in controlling an unusual and aggressive osteogenic sarcoma of the facial bone and sinuses.

Authors:
 [1];  [1];  [2]
  1. Midwest Institute for Neutron Therapy at Fermilab, P.O. Box 500 MS301, Batavia, Illinois Provena Saint Joseph Hospital, Elgin, Illinois 60510, USA
  2. University of Illinois College of Medicine, Peoria, Illinois, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1198212
Grant/Contract Number:  
AC02-76CHO3000
Resource Type:
Published Article
Journal Name:
Sarcoma
Additional Journal Information:
Journal Name: Sarcoma Journal Volume: 3 Journal Issue: 2; Journal ID: ISSN 1357-714X
Publisher:
Hindawi Publishing Corporation
Country of Publication:
Country unknown/Code not available
Language:
English

Citation Formats

Smoron, Geoffrey L., Lennox, Arlene J., and Mcgee, James L. Osteogenic Sarcoma of the Maxilla: Neutron Therapy for Unresectable Disease. Country unknown/Code not available: N. p., 1999. Web. doi:10.1080/13577149977785.
Smoron, Geoffrey L., Lennox, Arlene J., & Mcgee, James L. Osteogenic Sarcoma of the Maxilla: Neutron Therapy for Unresectable Disease. Country unknown/Code not available. doi:10.1080/13577149977785.
Smoron, Geoffrey L., Lennox, Arlene J., and Mcgee, James L. Fri . "Osteogenic Sarcoma of the Maxilla: Neutron Therapy for Unresectable Disease". Country unknown/Code not available. doi:10.1080/13577149977785.
@article{osti_1198212,
title = {Osteogenic Sarcoma of the Maxilla: Neutron Therapy for Unresectable Disease},
author = {Smoron, Geoffrey L. and Lennox, Arlene J. and Mcgee, James L.},
abstractNote = {Purpose. To present a case study involving the use of fast neutron therapy to treat an extensive unresectable osteogenic sarcoma arising from the left maxilla. Patient. A 14-year-old male presented with a massive tumor producing severe distortion of his facial structures. He had already received six courses of chemotherapy, which had reduced his pain, but had not measurably reduced the tumor. Methods. The patient was treated with 66 MeV fast neutrons to a dose of 20.4 Gy in 13 fractions over 35 days. Results. CT assessments indicate gradually increasing calcification and noticeable reduction of soft-tissue disease in the frontal sinus, orbit and maxillary antrum.There has been some recontouring of the facial structures.The boy conducts an active life, has no pain, and feels well. He was 17 years old at the last follow-up. Discussion. Fast neutrons have a greater biological effectiveness than conventional photon beams. Their use has been associated with improved chance for local control of unresectable disease.This case illustrates their effectiveness in controlling an unusual and aggressive osteogenic sarcoma of the facial bone and sinuses.},
doi = {10.1080/13577149977785},
journal = {Sarcoma},
number = 2,
volume = 3,
place = {Country unknown/Code not available},
year = {1999},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1080/13577149977785

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