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Title: Proteolysis in hyperthermophilic microorganisms

Abstract

Proteases are found in every cell, where they recognize and break down unneeded or abnormal polypeptides or peptide-based nutrients within or outside the cell. Genome sequence data can be used to compare proteolytic enzyme inventories of different organisms as they relate to physiological needs for protein modification and hydrolysis. In this review, we exploit genome sequence data to compare hyperthermophilic microorganisms from the euryarchaeotal genus Pyrococcus , the crenarchaeote Sulfolobus solfataricus , and the bacterium Thermotoga maritima . An overview of the proteases in these organisms is given based on those proteases that have been characterized and on putative proteases that have been identified from genomic sequences, but have yet to be characterized. The analysis revealed both similarities and differences in the mechanisms utilized for proteolysis by each of these hyperthermophiles and indicated how these mechanisms relate to proteolysis in less thermophilic cells and organisms.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1];  [1]
  1. Department of Chemical Engineering, North Carolina State University, Raleigh, NC 27695-7905, USA
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1198192
Resource Type:
Published Article
Journal Name:
Archaea
Additional Journal Information:
Journal Name: Archaea Journal Volume: 1 Journal Issue: 1; Journal ID: ISSN 1472-3646
Publisher:
Hindawi Publishing Corporation
Country of Publication:
United States
Language:
English

Citation Formats

Ward, Donald E., Shockley, Keith R., Chang, Lara S., Levy, Ryan D., Michel, Joshua K., Conners, Shannon B., and Kelly, Robert M. Proteolysis in hyperthermophilic microorganisms. United States: N. p., 2002. Web. doi:10.1155/2002/503191.
Ward, Donald E., Shockley, Keith R., Chang, Lara S., Levy, Ryan D., Michel, Joshua K., Conners, Shannon B., & Kelly, Robert M. Proteolysis in hyperthermophilic microorganisms. United States. doi:10.1155/2002/503191.
Ward, Donald E., Shockley, Keith R., Chang, Lara S., Levy, Ryan D., Michel, Joshua K., Conners, Shannon B., and Kelly, Robert M. Tue . "Proteolysis in hyperthermophilic microorganisms". United States. doi:10.1155/2002/503191.
@article{osti_1198192,
title = {Proteolysis in hyperthermophilic microorganisms},
author = {Ward, Donald E. and Shockley, Keith R. and Chang, Lara S. and Levy, Ryan D. and Michel, Joshua K. and Conners, Shannon B. and Kelly, Robert M.},
abstractNote = {Proteases are found in every cell, where they recognize and break down unneeded or abnormal polypeptides or peptide-based nutrients within or outside the cell. Genome sequence data can be used to compare proteolytic enzyme inventories of different organisms as they relate to physiological needs for protein modification and hydrolysis. In this review, we exploit genome sequence data to compare hyperthermophilic microorganisms from the euryarchaeotal genus Pyrococcus , the crenarchaeote Sulfolobus solfataricus , and the bacterium Thermotoga maritima . An overview of the proteases in these organisms is given based on those proteases that have been characterized and on putative proteases that have been identified from genomic sequences, but have yet to be characterized. The analysis revealed both similarities and differences in the mechanisms utilized for proteolysis by each of these hyperthermophiles and indicated how these mechanisms relate to proteolysis in less thermophilic cells and organisms.},
doi = {10.1155/2002/503191},
journal = {Archaea},
number = 1,
volume = 1,
place = {United States},
year = {2002},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1155/2002/503191

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