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Title: The Adipose Renin-Angiotensin System Modulates Systemic Markers of Insulin Sensitivity and Activates the Intrarenal Renin-Angiotensin System

Abstract

Background . The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism. Methods and results . A panel of mouse models including mice lacking angiotensinogen, Agt ( Agt -KO), mice expressing Agt solely in adipose tissue (aP2- Agt/Agt -KO), and mice overexpressing Agt in adipose tissue (aP2- Agt ) was studied. Total body weight, epididymal fat pad weight, and circulating levels of leptin, insulin, and resistin were significantly decreased in Agt -KO mice, while plasma adiponectin levels were increased. aP2- Agt mice exhibited increased adiposity and plasma leptin and insulin levels compared to wild type (WT) controls. Angiotensinogen and type I Ang II receptor protein levels were also elevated in kidney of aP2- Agt mice. Conclusion . These findings demonstrate that alterations in adipose RAS activity significantly impact both local and systemic physiology in a way that may contribute to the detrimental health effects of obesity.

Authors:
; ; ; ; ; ; ; ;
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1198186
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Published Article
Journal Name:
Journal of Biomedicine and Biotechnology
Additional Journal Information:
Journal Name: Journal of Biomedicine and Biotechnology Journal Volume: 2006; Journal ID: ISSN 1110-7243
Publisher:
Hindawi Publishing Corporation
Country of Publication:
Country unknown/Code not available
Language:
English

Citation Formats

Kim, Suyeon, Soltani-Bejnood, Morvarid, Quignard-Boulange, Annie, Massiera, Florence, Teboul, Michele, Ailhaud, Gerard, Kim, Jung Han, Moustaid-Moussa, Naima, and Voy, Brynn H. The Adipose Renin-Angiotensin System Modulates Systemic Markers of Insulin Sensitivity and Activates the Intrarenal Renin-Angiotensin System. Country unknown/Code not available: N. p., 2006. Web. doi:10.1155/JBB/2006/27012.
Kim, Suyeon, Soltani-Bejnood, Morvarid, Quignard-Boulange, Annie, Massiera, Florence, Teboul, Michele, Ailhaud, Gerard, Kim, Jung Han, Moustaid-Moussa, Naima, & Voy, Brynn H. The Adipose Renin-Angiotensin System Modulates Systemic Markers of Insulin Sensitivity and Activates the Intrarenal Renin-Angiotensin System. Country unknown/Code not available. doi:10.1155/JBB/2006/27012.
Kim, Suyeon, Soltani-Bejnood, Morvarid, Quignard-Boulange, Annie, Massiera, Florence, Teboul, Michele, Ailhaud, Gerard, Kim, Jung Han, Moustaid-Moussa, Naima, and Voy, Brynn H. Sun . "The Adipose Renin-Angiotensin System Modulates Systemic Markers of Insulin Sensitivity and Activates the Intrarenal Renin-Angiotensin System". Country unknown/Code not available. doi:10.1155/JBB/2006/27012.
@article{osti_1198186,
title = {The Adipose Renin-Angiotensin System Modulates Systemic Markers of Insulin Sensitivity and Activates the Intrarenal Renin-Angiotensin System},
author = {Kim, Suyeon and Soltani-Bejnood, Morvarid and Quignard-Boulange, Annie and Massiera, Florence and Teboul, Michele and Ailhaud, Gerard and Kim, Jung Han and Moustaid-Moussa, Naima and Voy, Brynn H.},
abstractNote = {Background . The adipose tissue renin-angiotensin system (RAS) contributes to regulation of fat mass and may also impact systemic functions such as blood pressure and metabolism. Methods and results . A panel of mouse models including mice lacking angiotensinogen, Agt ( Agt -KO), mice expressing Agt solely in adipose tissue (aP2- Agt/Agt -KO), and mice overexpressing Agt in adipose tissue (aP2- Agt ) was studied. Total body weight, epididymal fat pad weight, and circulating levels of leptin, insulin, and resistin were significantly decreased in Agt -KO mice, while plasma adiponectin levels were increased. aP2- Agt mice exhibited increased adiposity and plasma leptin and insulin levels compared to wild type (WT) controls. Angiotensinogen and type I Ang II receptor protein levels were also elevated in kidney of aP2- Agt mice. Conclusion . These findings demonstrate that alterations in adipose RAS activity significantly impact both local and systemic physiology in a way that may contribute to the detrimental health effects of obesity.},
doi = {10.1155/JBB/2006/27012},
journal = {Journal of Biomedicine and Biotechnology},
number = ,
volume = 2006,
place = {Country unknown/Code not available},
year = {2006},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1155/JBB/2006/27012

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Cited by: 39 works
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