Title: A Comparison of Hyperelastic Warping of PET Images with Tagged MRI for the Analysis of Cardiac Deformation

Abstract

The objectives of the following research were to evaluate the utility of a deformable image registration technique known as hyperelastic warping for the measurement of local strains in the left ventricle through the analysis of clinical, gated PET image datasets. Two normal human male subjects were sequentially imaged with PET and tagged MRI imaging. Strain predictions were made for systolic contraction using warping analyses of the PET images and HARP based strain analyses of the MRI images. Coefficient of determination $R^2$ values were computed for the comparison of circumferential and radial strain predictions produced by each methodology. There was good correspondence between the methodologies, with $R^2$ values of 0.78 for the radial strains of both hearts and from an $R^2=0.81$ and $R^2=0.83$ for the circumferential strains. The strain predictions were not statistically different $\left(P\le 0.01\right)$ . A series of sensitivity results indicated that the methodology was relatively insensitive to alterations in image intensity, random image noise, and alterations in fiber structure. This study demonstrated that warping was able to provide strain predictions of systolic contraction of the LV consistent with those provided by tagged MRI Warping.

Authors:

Veress, Alexander I. ^[1]; Klein, Gregory ^[2]; Gullberg, Grant T. ^[3]

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+ Show Author Affiliations

1. Department of Mechanical Engineering, University of Washington, Seattle Washington, Stevens Way, P.O. Box 352600, Seattle, WA 98195, USA
2. Synarc Inc., Newark, CA 94560, USA
3. Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA, Department of Radiology, University of California San Francisco, San Francisco, CA 94143, USA

Publication Date:

Tue Jan 01 00:00:00 EST 2013

Research Org.:

Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:

USDOE Office of Science (SC), Biological and Environmental Research (BER). Biological Systems Science Division; National Institutes of Health (NIH)

OSTI Identifier:

1198170

Alternate Identifier(s):

OSTI ID: 1629224

Grant/Contract Number:  

AC02-05CH11231; R03 EB008450; R01 EB07219; R01 EB000121

Resource Type:

Published Article

Journal Name:

International Journal of Biomedical Imaging (Print)

Additional Journal Information:

Journal Name: International Journal of Biomedical Imaging (Print) Journal Volume: 2013; Journal ID: ISSN 1687-4188

Publisher:

Hindawi Publishing Corporation

Country of Publication:

France

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES