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Title: Radiation May Indirectly Impair Growth Resulting in Reduced Standing Height via Subclinical Inflammation in Atomic-Bomb Survivors Exposed at Young Ages

Abstract

For young atomic-bomb (A-bomb) survivors, A-bomb radiation’s (total) effect on standing height is thought to comprise the sum of direct effect and indirect effect via inflammation. With the data of five inflammatory markers—white blood cell count, sialic acid, corrected erythrocyte sedimentation rate (ESR), α 1 globulin, and α 2 globulin—obtained in adulthood during the period 1988 to 1992, a summary inflammatory index was constructed as a surrogate for the five subclinical inflammatory markers. For 3,327 A-bomb survivors exposed at ages of less than 25 years, a structural equation model was analyzed to measure direct radiation effects on adult height as well as mediating effect of radiation via inflammation on the height after adjustment for other risk factors, smoking, cancer, inflammatory disease, obesity, and diabetes mellitus. The mediation proportion of the radiation effect on height via inflammation was approximately 5% for both sexes for all ages, and indirect dose effects via inflammation were statistically significant for both sexes combined and for females exposed at ages 0 to 5 years. Indirect dose effects for all ages via sialic acid, corrected ESR, and α 2 globulin were marginally significant for both sexes combined and for females. These proportions are likely underestimated.

Authors:
 [1];  [2];  [1]
  1. Department of Statistics, Radiation Effects Research Foundation, Hijiyama Park 5-2, Minami-ku, Hiroshima 732-0815, Japan
  2. Department of Clinical Studies, Radiation Effects Research Foundation, Hijiyama Park 5-2, Minami-ku, Hiroshima 732-0815, Japan
Publication Date:
Sponsoring Org.:
USDOE
OSTI Identifier:
1198075
Grant/Contract Number:  
HS0000031
Resource Type:
Published Article
Journal Name:
Epidemiology Research International
Additional Journal Information:
Journal Name: Epidemiology Research International Journal Volume: 2015; Journal ID: ISSN 2090-2972
Publisher:
Hindawi Publishing Corporation
Country of Publication:
Country unknown/Code not available
Language:
English

Citation Formats

Nakashima, Eiji, Neriishi, Kazuo, and Hsu, Wan-Ling. Radiation May Indirectly Impair Growth Resulting in Reduced Standing Height via Subclinical Inflammation in Atomic-Bomb Survivors Exposed at Young Ages. Country unknown/Code not available: N. p., 2015. Web. doi:10.1155/2015/295958.
Nakashima, Eiji, Neriishi, Kazuo, & Hsu, Wan-Ling. Radiation May Indirectly Impair Growth Resulting in Reduced Standing Height via Subclinical Inflammation in Atomic-Bomb Survivors Exposed at Young Ages. Country unknown/Code not available. doi:10.1155/2015/295958.
Nakashima, Eiji, Neriishi, Kazuo, and Hsu, Wan-Ling. Thu . "Radiation May Indirectly Impair Growth Resulting in Reduced Standing Height via Subclinical Inflammation in Atomic-Bomb Survivors Exposed at Young Ages". Country unknown/Code not available. doi:10.1155/2015/295958.
@article{osti_1198075,
title = {Radiation May Indirectly Impair Growth Resulting in Reduced Standing Height via Subclinical Inflammation in Atomic-Bomb Survivors Exposed at Young Ages},
author = {Nakashima, Eiji and Neriishi, Kazuo and Hsu, Wan-Ling},
abstractNote = {For young atomic-bomb (A-bomb) survivors, A-bomb radiation’s (total) effect on standing height is thought to comprise the sum of direct effect and indirect effect via inflammation. With the data of five inflammatory markers—white blood cell count, sialic acid, corrected erythrocyte sedimentation rate (ESR), α 1 globulin, and α 2 globulin—obtained in adulthood during the period 1988 to 1992, a summary inflammatory index was constructed as a surrogate for the five subclinical inflammatory markers. For 3,327 A-bomb survivors exposed at ages of less than 25 years, a structural equation model was analyzed to measure direct radiation effects on adult height as well as mediating effect of radiation via inflammation on the height after adjustment for other risk factors, smoking, cancer, inflammatory disease, obesity, and diabetes mellitus. The mediation proportion of the radiation effect on height via inflammation was approximately 5% for both sexes for all ages, and indirect dose effects via inflammation were statistically significant for both sexes combined and for females exposed at ages 0 to 5 years. Indirect dose effects for all ages via sialic acid, corrected ESR, and α 2 globulin were marginally significant for both sexes combined and for females. These proportions are likely underestimated.},
doi = {10.1155/2015/295958},
journal = {Epidemiology Research International},
number = ,
volume = 2015,
place = {Country unknown/Code not available},
year = {2015},
month = {1}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
DOI: 10.1155/2015/295958

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