Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response

Busch, Andrea W. U.; Montgomery, Beronda L.

doi:10.1016/j.redox.2015.01.010

Title: Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response

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Abstract

Tetrapyrroles are involved in light harvesting and light perception, electron-transfer reactions, and as co-factors for key enzymes and sensory proteins. Under conditions in which cells exhibit stress-induced imbalances of photosynthetic reactions, or light absorption exceeds the ability of the cell to use photoexcitation energy in synthesis reactions, redox imbalance can occur in photosynthetic cells. Such conditions can lead to the generation of reactive oxygen species (ROS) associated with alterations in tetrapyrrole homeostasis. ROS accumulation can result in cellular damage and detrimental effects on organismal fitness, or ROS molecules can serve as signals to induce a protective or damage-mitigating oxidative stress signaling response in cells. Induced oxidative stress responses include tetrapyrrole-dependent and -independent mechanisms for mitigating ROS generation and/or accumulation. Thus, tetrapyrroles can be contributors to oxidative stress, but are also essential in the oxidative stress response to protect cells by contributing to detoxification of ROS. In this review, we highlight the interconnection and interdependence of tetrapyrrole metabolism with the occurrence of oxidative stress and protective oxidative stress signaling responses in photosynthetic organisms.

Authors:: Busch, Andrea W. U.; Montgomery, Beronda L.

Publication Date:: Wed Apr 01 00:00:00 EDT 2015

Research Org.:: Michigan State Univ., East Lansing, MI (United States). MSU-DOE Plant Research Laboratory

Sponsoring Org.:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

OSTI Identifier:: 1197792

Alternate Identifier(s):: OSTI ID: 1602541

Grant/Contract Number:: FG; FG02-91ER20021

Resource Type:: Published Article

Journal Name:: Redox Biology

Additional Journal Information:: Journal Name: Redox Biology Journal Volume: 4 Journal Issue: C; Journal ID: ISSN 2213-2317

Publisher:: Elsevier

Country of Publication:: Netherlands

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

Citation Formats


                    Busch, Andrea W. U., and Montgomery, Beronda L. Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response.  Netherlands: N. p., 2015. 
Web.  doi:10.1016/j.redox.2015.01.010.

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                    Busch, Andrea W. U., & Montgomery, Beronda L. Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response.  Netherlands.  https://doi.org/10.1016/j.redox.2015.01.010

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                    Busch, Andrea W. U., and Montgomery, Beronda L. Wed .  
"Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response".  Netherlands.  https://doi.org/10.1016/j.redox.2015.01.010.

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@article{osti_1197792,

  title        = {Interdependence of tetrapyrrole metabolism, the generation of oxidative stress and the mitigative oxidative stress response},

  author       = {Busch, Andrea W. U. and Montgomery, Beronda L.},

  abstractNote = {Tetrapyrroles are involved in light harvesting and light perception, electron-transfer reactions, and as co-factors for key enzymes and sensory proteins. Under conditions in which cells exhibit stress-induced imbalances of photosynthetic reactions, or light absorption exceeds the ability of the cell to use photoexcitation energy in synthesis reactions, redox imbalance can occur in photosynthetic cells. Such conditions can lead to the generation of reactive oxygen species (ROS) associated with alterations in tetrapyrrole homeostasis. ROS accumulation can result in cellular damage and detrimental effects on organismal fitness, or ROS molecules can serve as signals to induce a protective or damage-mitigating oxidative stress signaling response in cells. Induced oxidative stress responses include tetrapyrrole-dependent and -independent mechanisms for mitigating ROS generation and/or accumulation. Thus, tetrapyrroles can be contributors to oxidative stress, but are also essential in the oxidative stress response to protect cells by contributing to detoxification of ROS. In this review, we highlight the interconnection and interdependence of tetrapyrrole metabolism with the occurrence of oxidative stress and protective oxidative stress signaling responses in photosynthetic organisms.},

  doi          = {10.1016/j.redox.2015.01.010},

  journal      = {Redox Biology},

  number       = C,

  volume       = 4,

  place        = {Netherlands},

  year         = {Wed Apr 01 00:00:00 EDT 2015},

  month        = {Wed Apr 01 00:00:00 EDT 2015}

}

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