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Title: Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser

Abstract

Light absorption can trigger biologically relevant protein conformational changes. The light induced structural rearrangement at the level of a photoexcited chromophore is known to occur in the femtosecond timescale and is expected to propagate through the protein as a quake-like intramolecular motion. Here we report direct experimental evidence of such ‘proteinquake’ observed in myoglobin through femtosecond X-ray solution scattering measurements performed at the Linac Coherent Light Source X-ray free-electron laser. An ultrafast increase of myoglobin radius of gyration occurs within 1 picosecond and is followed by a delayed protein expansion. As the system approaches equilibrium it undergoes damped oscillations with a ~3.6-picosecond time period. Our results unambiguously show how initially localized chemical changes can propagate at the level of the global protein conformation in the picosecond timescale.

Authors:
 [1];  [2];  [3];  [1];  [3];  [3];  [3];  [4];  [5];  [1];  [6]
+ Show Author Affiliations
  1. Univ. of Palermo (Italy). Dept. of Physics.
  2. Univ. of Grenoble Alpes and Institute of Structural Biology (France)
  3. SLAC National Accelerator Laboratory, Menlo Park, CA (Untied States)
  4. Inst. for Basic Science (IBS), Daejeon (Republic of Korea)
  5. Republic of Korea
  6. Univ. of Rennes (France). Dept. of Physics.
Publication Date:
Research Org.:
SLAC National Accelerator Laboratory (SLAC), Menlo Park, CA (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1189945
Resource Type:
Accepted Manuscript
Journal Name:
Nature Communications
Additional Journal Information:
Journal Volume: 6; Journal Issue: 3; Journal ID: ISSN 2041-1723
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Levantino, Matteo, Schirò, Giorgio, Lemke, Henrik Till, Cottone, Grazia, Glownia, James Michael, Zhu, Diling, Chollet, Mathieu, Ihee, Hyotcherl, KAIST, Daejeon, Cupane, Antonio, and Cammarata, Marco. Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser. United States: N. p., 2015. Web. doi:10.1038/ncomms7772.
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Levantino, Matteo, Schirò, Giorgio, Lemke, Henrik Till, Cottone, Grazia, Glownia, James Michael, Zhu, Diling, Chollet, Mathieu, Ihee, Hyotcherl, KAIST, Daejeon, Cupane, Antonio, & Cammarata, Marco. Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser. United States. https://doi.org/10.1038/ncomms7772
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Levantino, Matteo, Schirò, Giorgio, Lemke, Henrik Till, Cottone, Grazia, Glownia, James Michael, Zhu, Diling, Chollet, Mathieu, Ihee, Hyotcherl, KAIST, Daejeon, Cupane, Antonio, and Cammarata, Marco. Thu . "Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser". United States. https://doi.org/10.1038/ncomms7772. https://www.osti.gov/servlets/purl/1189945.
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@article{osti_1189945,
title = {Ultrafast myoglobin structural dynamics observed with an X-ray free-electron laser},
author = {Levantino, Matteo and Schirò, Giorgio and Lemke, Henrik Till and Cottone, Grazia and Glownia, James Michael and Zhu, Diling and Chollet, Mathieu and Ihee, Hyotcherl and KAIST, Daejeon and Cupane, Antonio and Cammarata, Marco},
abstractNote = {Light absorption can trigger biologically relevant protein conformational changes. The light induced structural rearrangement at the level of a photoexcited chromophore is known to occur in the femtosecond timescale and is expected to propagate through the protein as a quake-like intramolecular motion. Here we report direct experimental evidence of such ‘proteinquake’ observed in myoglobin through femtosecond X-ray solution scattering measurements performed at the Linac Coherent Light Source X-ray free-electron laser. An ultrafast increase of myoglobin radius of gyration occurs within 1 picosecond and is followed by a delayed protein expansion. As the system approaches equilibrium it undergoes damped oscillations with a ~3.6-picosecond time period. Our results unambiguously show how initially localized chemical changes can propagate at the level of the global protein conformation in the picosecond timescale.},
doi = {10.1038/ncomms7772},
journal = {Nature Communications},
number = 3,
volume = 6,
place = {United States},
year = {Thu Apr 02 00:00:00 EDT 2015},
month = {Thu Apr 02 00:00:00 EDT 2015}
}
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https://doi.org/10.1038/ncomms7772
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Works referenced in this record:

The energy landscapes and motions of proteins
journal, December 1991

Dynamic personalities of proteins
journal, December 2007

  • Henzler-Wildman, Katherine; Kern, Dorothee
  • Nature, Vol. 450, Issue 7172
  • DOI: 10.1038/nature06522

Femtosecond Biology
journal, June 1992

Myoglobin: The hydrogen atom of biology and a paradigm of complexity
journal, July 2003

  • Frauenfelder, H.; McMahon, B. H.; Fenimore, P. W.
  • Proceedings of the National Academy of Sciences, Vol. 100, Issue 15
  • DOI: 10.1073/pnas.1633688100

Myoglobin, a Paradigm in the Study of Protein Dynamics
journal, March 2002

Photophysics and reactivity of heme proteins: a femtosecond absorption study of hemoglobin, myoglobin, and protoheme
journal, May 1988

  • Petrich, J. W.; Poyart, C.; Martin, J. L.
  • Biochemistry, Vol. 27, Issue 11
  • DOI: 10.1021/bi00411a022

Nonexponential protein relaxation: dynamics of conformational change in myoglobin.
journal, June 1993

  • Lim, M.; Jackson, T. A.; Anfinrud, P. A.
  • Proceedings of the National Academy of Sciences, Vol. 90, Issue 12
  • DOI: 10.1073/pnas.90.12.5801

Conformational Relaxation and Ligand Binding in Myoglobin
journal, May 1994

  • Ansari, Anjum; Jones, Colleen M.; Henry, Eric R.
  • Biochemistry, Vol. 33, Issue 17
  • DOI: 10.1021/bi00183a017

On the Origin of Heme Absorption Band Shifts and Associated Protein Structural Relaxation in Myoglobin following Flash Photolysis
journal, April 1997

  • Franzen, Stefan; Boxer, Steven G.
  • Journal of Biological Chemistry, Vol. 272, Issue 15
  • DOI: 10.1074/jbc.272.15.9655

Spectroscopic Evidence for Nanosecond Protein Relaxation after Photodissociation of Myoglobin−CO †
journal, December 1998

  • Esquerra, Raymond M.; Goldbeck, Robert A.; Kim-Shapiro, Daniel B.
  • Biochemistry, Vol. 37, Issue 50
  • DOI: 10.1021/bi9814437

Observation of sub-100ps conformational changes in photolyzed carbonmonoxy-myoglobin probed by time-resolved circular dichroism
journal, November 2005

Picosecond time-resolved Raman studies of photodissociated carboxymyoglobin
journal, May 1985

  • Findsen, Eric W.; Scott, Thomas W.; Chance, Mark R.
  • Journal of the American Chemical Society, Vol. 107, Issue 11
  • DOI: 10.1021/ja00297a056

Picosecond resonance Raman evidence for unrelaxed heme in the (carbonmonoxy)myoglobin photoproduct
journal, September 1985

  • Dasgupta, Siddharth; Spiro, Thomas G.; Johnson, Carey K.
  • Biochemistry, Vol. 24, Issue 20
  • DOI: 10.1021/bi00341a003

Primary protein response after ligand photodissociation in carbonmonoxy myoglobin
journal, May 2007

  • Sato, A.; Gao, Y.; Kitagawa, T.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 23
  • DOI: 10.1073/pnas.0611560104

A photoacoustic calorimetry study of horse carboxymyoglobin on the 10-nanosecond time scale
journal, October 1993

Direct observation of global protein motion in hemoglobin and myoglobin on picosecond time scales
journal, March 1991

Ultrafast Phase Grating Studies of Heme Proteins:  Observation of the Low-Frequency Modes Directing Functionally Important Protein Motions
journal, August 1998

  • Deàk, John; Chiu, Hui-Ling; Lewis, Caroline M.
  • The Journal of Physical Chemistry B, Vol. 102, Issue 34
  • DOI: 10.1021/jp980492q

Time-resolved resonance Raman study on ultrafast structural relaxation and vibrational cooling of photodissociated carbonmonoxy myoglobin
journal, January 2002

  • Kitagawa, Teizo; Haruta, Nami; Mizutani, Yasuhisa
  • Biopolymers, Vol. 67, Issue 4-5
  • DOI: 10.1002/bip.10096

A hierarchy of functionally important relaxations within myoglobin based on solvent effects, mutations and kinetic model
journal, June 2005

  • Dantsker, David; Samuni, Uri; Friedman, Joel M.
  • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, Vol. 1749, Issue 2
  • DOI: 10.1016/j.bbapap.2005.04.002

Protein states and proteinquakes.
journal, August 1985

  • Ansari, A.; Berendzen, J.; Bowne, S. F.
  • Proceedings of the National Academy of Sciences, Vol. 82, Issue 15
  • DOI: 10.1073/pnas.82.15.5000

Ultrafast Proteinquake Dynamics in Cytochrome c
journal, March 2009

  • Zang, Chen; Stevens, Jeffrey A.; Link, Justin J.
  • Journal of the American Chemical Society, Vol. 131, Issue 8
  • DOI: 10.1021/ja8057293

Formation of a New Buried Charge Drives a Large-Amplitude Protein Quake in Photoreceptor Activation †
journal, February 2001

  • Xie, Aihua; Kelemen, Lorand; Hendriks, Johnny
  • Biochemistry, Vol. 40, Issue 6
  • DOI: 10.1021/bi002449a

Dynamical transition and proteinquake in photoactive yellow protein
journal, October 2004

  • Itoh, K.; Sasai, M.
  • Proceedings of the National Academy of Sciences, Vol. 101, Issue 41
  • DOI: 10.1073/pnas.0402978101

Thermal-triggerd Proteinquake Leads to Disassembly of DegP Hexamer as an Imperative Activation Step
journal, April 2014

  • Li, Shanshan; Wang, Rui; Li, Deyong
  • Scientific Reports, Vol. 4, Issue 1
  • DOI: 10.1038/srep04834

Molecular Dynamics Study on the Solvent Dependent Heme Cooling Following Ligand Photolysis in Carbonmonoxy Myoglobin
journal, March 2007

  • Zhang, Yong; Fujisaki, Hiroshi; Straub, John E.
  • The Journal of Physical Chemistry B, Vol. 111, Issue 12
  • DOI: 10.1021/jp065877k

Vibrational energy relaxation processes in heme proteins: model systems of vibrational energy dispersion in disordered systems
journal, October 1987

  • Genberg, Laura.; Heisel, F.; McLendon, G.
  • The Journal of Physical Chemistry, Vol. 91, Issue 22
  • DOI: 10.1021/j100306a002

Visualizing a protein quake with time-resolved X-ray scattering at a free-electron laser
journal, August 2014

  • Arnlund, David; Johansson, Linda C.; Wickstrand, Cecilia
  • Nature Methods, Vol. 11, Issue 9
  • DOI: 10.1038/nmeth.3067

Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering
journal, September 2008

  • Cammarata, Marco; Levantino, Matteo; Schotte, Friedrich
  • Nature Methods, Vol. 5, Issue 10
  • DOI: 10.1038/nmeth.1255

Protein structural dynamics in solution unveiled via 100-ps time-resolved x-ray scattering
journal, April 2010

  • Cho, H. S.; Dashdorj, N.; Schotte, F.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 16
  • DOI: 10.1073/pnas.1002951107

Conformational Substates of Myoglobin Intermediate Resolved by Picosecond X-ray Solution Scattering
journal, February 2014

  • Oang, Key Young; Kim, Jong Goo; Yang, Cheolhee
  • The Journal of Physical Chemistry Letters, Vol. 5, Issue 5
  • DOI: 10.1021/jz4027425

Protein Tertiary Structural Changes Visualized by Time-Resolved X-ray Solution Scattering
journal, October 2009

  • Ahn, Sena; Kim, Kyung Hwan; Kim, Youngmin
  • The Journal of Physical Chemistry B, Vol. 113, Issue 40
  • DOI: 10.1021/jp906983v

Small-angle scattering studies of biological macromolecules in solution
journal, September 2003

Vibrational Energy Transfer and Heat Conduction in a Protein
journal, February 2003

  • Yu, Xin; Leitner, David M.
  • The Journal of Physical Chemistry B, Vol. 107, Issue 7
  • DOI: 10.1021/jp026462b

Structural Dynamics of Light-Driven Proton Pumps
journal, September 2009

Signal amplification and transduction in phytochrome photosensors
journal, April 2014

  • Takala, Heikki; Björling, Alexander; Berntsson, Oskar
  • Nature, Vol. 509, Issue 7499
  • DOI: 10.1038/nature13310

Relaxation dynamics of myoglobin in solution
journal, January 1992

Anisotropic energy flow and allosteric ligand binding in albumin
journal, January 2014

  • Li, Guifeng; Magana, Donny; Dyer, R. Brian
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms4100

Proton-powered subunit rotation in single membrane-bound F0F1-ATP synthase
journal, January 2004

  • Diez, Manuel; Zimmermann, Boris; Börsch, Michael
  • Nature Structural & Molecular Biology, Vol. 11, Issue 2
  • DOI: 10.1038/nsmb718

Deoxymyoglobin studied by the conformational normal mode analysis
journal, November 1990

Terahertz underdamped vibrational motion governs protein-ligand binding in solution
journal, June 2014

  • Turton, David A.; Senn, Hans Martin; Harwood, Thomas
  • Nature Communications, Vol. 5, Issue 1
  • DOI: 10.1038/ncomms4999

Achieving few-femtosecond time-sorting at hard X-ray free-electron lasers
journal, February 2013

First lasing and operation of an ångstrom-wavelength free-electron laser
journal, August 2010

Low-frequency acoustic phonons in nanometric CeO2 particles
journal, July 2005

  • Talati, Mina; Jha, Prafulla K.
  • Physica E: Low-dimensional Systems and Nanostructures, Vol. 28, Issue 2
  • DOI: 10.1016/j.physe.2005.03.001

Deoxymyoglobin studied by the conformational normal mode analysis
journal, November 1990

Structural Dynamics of Light-Driven Proton Pumps
journal, January 2010

  • Andersson, Magnus; Malmerberg, Erik; Westenhoff, Sebastian
  • Biophysical Journal, Vol. 98, Issue 3
  • DOI: 10.1016/j.bpj.2009.12.1222

Nonexponential protein relaxation: Dynamics of conformational change in myoglobin [Correction]
journal, September 1993

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    journal, January 2017

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    journal, January 2018

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    • Faraday Discussions, Vol. 207
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    journal, November 2015

    • Marino, A.; Cammarata, M.; Matar, S. F.
    • Structural Dynamics, Vol. 3, Issue 2
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    Experimental demonstration of a single-spike hard-X-ray free-electron laser starting from noise
    journal, October 2017

    • Marinelli, A.; MacArthur, J.; Emma, P.
    • Applied Physics Letters, Vol. 111, Issue 15
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    journal, April 2018

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    journal, February 2019

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    journal, September 2016

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