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Title: A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging

Journal Article · · Scientific Reports
DOI: https://doi.org/10.1038/srep09194 · OSTI ID:1185340
 [1];  [2];  [3];  [4];  [5];  [5];  [6];  [5];  [7];  [8];  [9];  [5];  [5];  [10];  [6];  [2];  [11];  [12];  [13];  [5]
  1. IHI Corp., Yokohama (Japan)
  2. Japan Synchrotron Radiation Research Institute, Hyogo (Japan)
  3. Yamagata Univ. (Japan)
  4. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  5. Yokohama City Univ. (Japan)
  6. Yokohama National Univ. (Japan)
  7. Univ. of Tokyo (Japan)
  8. Kyoto Univ. (Japan)
  9. Konan Univ., Kobe (Japan)
  10. Aichi Medical Univ., Aichi(Japan)
  11. National Inst. of Radiological Sciences, Chiba (Japan)
  12. Tohoku Univ., Sendai (Japan)
  13. International Graduate School of Arts and Sciences, Yokohama (Japan)
+ Show Author Affiliations

New anticancer agents and modalities for their use are of great interest. Recent studies have demonstrated the presence of anti-cancer properties in salen derivatives. We found that an iron salen derivative, i.e., [Fe(salen)]2O, displays ferromagnetic order above room temperature and shows spontaneous field-dependent magnetization and hysteresis. Understanding of this magnetic property is provided by first-principles calculations based on structures obtained by X-ray crystallography. [Fe(salen)]2O exhibited potent anti-cancer properties against various cancer cell types and was readily attracted by even moderate-strength permanent magnets in vitro. We demonstrated that the delivery of [Fe(salen)]2O to melanoma tissues transplanted into the tails of mice using a permanent magnet leads to a robust decrease in tumor size. The local accumulation of [Fe(salen)]2O was visualized by MRI. Thus, [Fe(salen)]2O acted as an anti-cancer and MRI contrast compound that has a pharmacological effect that is delivered in a controlled manner, suggesting new strategies for anti-cancer drug development.

Research Organization:
Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
Grant/Contract Number:
AC05-00OR22725
OSTI ID:
1185340
Journal Information:
Scientific Reports, Vol. 5; ISSN 2045-2322
Publisher:
Nature Publishing GroupCopyright Statement
Country of Publication:
United States
Language:
English

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Cited By (15)

Controlled Drug Delivery Systems for Oral Cancer Treatment—Current Status and Future Perspectives journal June 2019
Hyperthermia and chemotherapy using Fe(Salen) nanoparticles might impact glioblastoma treatment journal February 2017
The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs journal June 2015
Syntheses and Structure Investigations of 3d Transition Metal Complexes with a Flexible N4O2-Donor Hexadentate Schiff-Base Ligand journal January 2017
Simultaneous hyperthermia-chemotherapy effect by arterial injection of Fe(Salen) for femur tumor journal December 2018
Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles journal April 2016
Alternating magnetic field enhances cytotoxicity of Compound C journal October 2018
Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling journal April 2018
Treatment of oral cancer using magnetized paclitaxel journal February 2018
Alternating magnetic field enhances cytotoxicity of Compound C journal October 2018
Acute Hyperthermia Inhibits TGF-β1-induced Cardiac Fibroblast Activation via Suppression of Akt Signaling journal April 2018
Simultaneous hyperthermia-chemotherapy with controlled drug delivery using single-drug nanoparticles journal April 2016
miR-663a regulates growth of colon cancer cells, after administration of antimicrobial peptides, by targeting CXCR4-p21 pathway journal January 2017
Green synthesis of near-infrared absorbing eugenate capped iron oxide nanoparticles for photothermal application journal December 2019
Perspective: Magnetoresistive sensors for biomedicine journal July 2018

Linked Research (1)

Figures / Tables (17)

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