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Title: A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging

Abstract

New anticancer agents and modalities for their use are of great interest. Recent studies have demonstrated the presence of anti-cancer properties in salen derivatives. We found that an iron salen derivative, i.e., [Fe(salen)] 2O, displays ferromagnetic order above room temperature and shows spontaneous field-dependent magnetization and hysteresis. Understanding of this magnetic property is provided by first-principles calculations based on structures obtained by X-ray crystallography. [Fe(salen)] 2O exhibited potent anti-cancer properties against various cancer cell types and was readily attracted by even moderate-strength permanent magnets in vitro. We demonstrated that the delivery of [Fe(salen)] 2O to melanoma tissues transplanted into the tails of mice using a permanent magnet leads to a robust decrease in tumor size. The local accumulation of [Fe(salen)] 2O was visualized by MRI. Thus, [Fe(salen)] 2O acted as an anti-cancer and MRI contrast compound that has a pharmacological effect that is delivered in a controlled manner, suggesting new strategies for anti-cancer drug development.

Authors:
 [1];  [2];  [3];  [4];  [5];  [5];  [6];  [5];  [7];  [8];  [9];  [5];  [5];  [10];  [6];  [2];  [11];  [12];  [13];  [5]
  1. IHI Corp., Yokohama (Japan)
  2. Japan Synchrotron Radiation Research Institute, Hyogo (Japan)
  3. Yamagata Univ. (Japan)
  4. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  5. Yokohama City Univ. (Japan)
  6. Yokohama National Univ. (Japan)
  7. Univ. of Tokyo (Japan)
  8. Kyoto Univ. (Japan)
  9. Konan Univ., Kobe (Japan)
  10. Aichi Medical Univ., Aichi(Japan)
  11. National Inst. of Radiological Sciences, Chiba (Japan)
  12. Tohoku Univ., Sendai (Japan)
  13. International Graduate School of Arts and Sciences, Yokohama (Japan)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE Office of Science (SC)
OSTI Identifier:
1185340
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
Scientific Reports
Additional Journal Information:
Journal Volume: 5; Journal ID: ISSN 2045-2322
Publisher:
Nature Publishing Group
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Eguchi, Haruki, Hirata, Kunio, Kurotani, Reiko, Singh, David J., Fukumura, Hidenobu, Umemura, Masanari, Hoshino, Yujiro, Lee, Jin, Masuda, Takatsugu, Amemiya, Naoyuki, Yamamoto, Masahiro, Sato, Itaru, Feng, Xianfeng, Sato, Motohiko, Inoue, Seiichi, Yamamoto, Masaki, Aoki, Ichio, Tanigaki, Katsumi, Sato, Mamoru, and Ishikawa, Yoshihiro. A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging. United States: N. p., 2015. Web. doi:10.1038/srep09194.
Eguchi, Haruki, Hirata, Kunio, Kurotani, Reiko, Singh, David J., Fukumura, Hidenobu, Umemura, Masanari, Hoshino, Yujiro, Lee, Jin, Masuda, Takatsugu, Amemiya, Naoyuki, Yamamoto, Masahiro, Sato, Itaru, Feng, Xianfeng, Sato, Motohiko, Inoue, Seiichi, Yamamoto, Masaki, Aoki, Ichio, Tanigaki, Katsumi, Sato, Mamoru, & Ishikawa, Yoshihiro. A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging. United States. doi:10.1038/srep09194.
Eguchi, Haruki, Hirata, Kunio, Kurotani, Reiko, Singh, David J., Fukumura, Hidenobu, Umemura, Masanari, Hoshino, Yujiro, Lee, Jin, Masuda, Takatsugu, Amemiya, Naoyuki, Yamamoto, Masahiro, Sato, Itaru, Feng, Xianfeng, Sato, Motohiko, Inoue, Seiichi, Yamamoto, Masaki, Aoki, Ichio, Tanigaki, Katsumi, Sato, Mamoru, and Ishikawa, Yoshihiro. Tue . "A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging". United States. doi:10.1038/srep09194. https://www.osti.gov/servlets/purl/1185340.
@article{osti_1185340,
title = {A ferromagnetic compound with anti-cancer proeprties for controlled drug delivery and imaging},
author = {Eguchi, Haruki and Hirata, Kunio and Kurotani, Reiko and Singh, David J. and Fukumura, Hidenobu and Umemura, Masanari and Hoshino, Yujiro and Lee, Jin and Masuda, Takatsugu and Amemiya, Naoyuki and Yamamoto, Masahiro and Sato, Itaru and Feng, Xianfeng and Sato, Motohiko and Inoue, Seiichi and Yamamoto, Masaki and Aoki, Ichio and Tanigaki, Katsumi and Sato, Mamoru and Ishikawa, Yoshihiro},
abstractNote = {New anticancer agents and modalities for their use are of great interest. Recent studies have demonstrated the presence of anti-cancer properties in salen derivatives. We found that an iron salen derivative, i.e., [Fe(salen)]2O, displays ferromagnetic order above room temperature and shows spontaneous field-dependent magnetization and hysteresis. Understanding of this magnetic property is provided by first-principles calculations based on structures obtained by X-ray crystallography. [Fe(salen)]2O exhibited potent anti-cancer properties against various cancer cell types and was readily attracted by even moderate-strength permanent magnets in vitro. We demonstrated that the delivery of [Fe(salen)]2O to melanoma tissues transplanted into the tails of mice using a permanent magnet leads to a robust decrease in tumor size. The local accumulation of [Fe(salen)]2O was visualized by MRI. Thus, [Fe(salen)]2O acted as an anti-cancer and MRI contrast compound that has a pharmacological effect that is delivered in a controlled manner, suggesting new strategies for anti-cancer drug development.},
doi = {10.1038/srep09194},
journal = {Scientific Reports},
number = ,
volume = 5,
place = {United States},
year = {2015},
month = {3}
}

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Cited by: 12 works
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Figures / Tables:

Figure 1 Figure 1: Magnetization versus magnetic field curves of [Fe(salen)]2O and other salen derivatives

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    Works referencing / citing this record:

    Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells: Fe(salen)Cl induces apoptosis in tumor cells
    journal, May 2014

    • Pradhan, Nitika; Pratheek, B. M.; Garai, Antara
    • Cell Biology International, Vol. 38, Issue 10
    • DOI: 10.1002/cbin.10308

    High optical performance and practicality of active plasmonic devices based on rhombohedral BiFeO3
    journal, July 2012


    Effects of rare-earth dopants on the thermally grown Al2O3/Ni(Al) interface: the first-principles prediction
    journal, January 2014


    Effect of ascorbic acid on reactive oxygen species production in chemotherapy and hyperthermia in prostate cancer cells
    journal, March 2012

    • Fukumura, Hidenobu; Sato, Motohiko; Kezuka, Kyouhei
    • The Journal of Physiological Sciences, Vol. 62, Issue 3
    • DOI: 10.1007/s12576-012-0204-0

    Hyperthermia generated with ferucarbotran (Resovist®) in an alternating magnetic field enhances cisplatin-induced apoptosis of cultured human oral cancer cells
    journal, March 2014

    • Sato, Itaru; Umemura, Masanari; Mitsudo, Kenji
    • The Journal of Physiological Sciences, Vol. 64, Issue 3
    • DOI: 10.1007/s12576-014-0309-8

    Effects of chloride ions on the iron(III)-catalyzed decomposition of hydrogen peroxide and on the efficiency of the Fenton-like oxidation process
    journal, June 2006


    Synthesis and surface engineering of iron oxide nanoparticles for biomedical applications
    journal, June 2005


    Rewired ERK-JNK Signaling Pathways in Melanoma
    journal, May 2007


    Iron(III)-salen damages DNA and induces apoptosis in human cell via mitochondrial pathway
    journal, April 2008


    A Knowledge-Based Approach in Designing Combinatorial or Medicinal Chemistry Libraries for Drug Discovery. 1. A Qualitative and Quantitative Characterization of Known Drug Databases
    journal, January 1999

    • Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J.
    • Journal of Combinatorial Chemistry, Vol. 1, Issue 1
    • DOI: 10.1021/cc9800071

    Catalytic Olefin Cyclopropanation Using μ-Oxo−bis[(salen)iron(III)] Complexes
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    • Edulji, Smita K.; Nguyen, SonBinh T.
    • Organometallics, Vol. 22, Issue 17
    • DOI: 10.1021/om020959q

    Structure and Paramagnetism of Five- and Six-Co-ordinate N : N′ Bis-salicylidene Ethylenediamine Iron(III) Chloride
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    • Gerloch, M.; Lewis, J.; Mabbs, F. E.
    • Nature, Vol. 212, Issue 5064
    • DOI: 10.1038/212809a0

    Imaging in the era of molecular oncology
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    A novel magnetic crystal–lipid nanostructure for magnetically guided in vivo gene delivery
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    • Namiki, Yoshihisa; Namiki, Tamami; Yoshida, Hiroshi
    • Nature Nanotechnology, Vol. 4, Issue 9
    • DOI: 10.1038/nnano.2009.202

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    • Jain, Rakesh K.; Stylianopoulos, Triantafyllos
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    • DOI: 10.1038/nrclinonc.2010.139

    Recent advances with liposomes as pharmaceutical carriers
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    • Torchilin, Vladimir P.
    • Nature Reviews Drug Discovery, Vol. 4, Issue 2
    • DOI: 10.1038/nrd1632

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    Overexpression of Catalase in Cytosolic or Mitochondrial Compartment Protects HepG2 Cells against Oxidative Injury
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    • Bai, Jingxiang; Rodriguez, Ana M.; Melendez, J. Andres
    • Journal of Biological Chemistry, Vol. 274, Issue 37
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    Ab initio screening methodology applied to the search for new permanent magnetic materials
    journal, December 2013


    Magnetic Resonance Imaging of Temperature-Sensitive Liposome Release: Drug Dose Painting and Antitumor Effects
    journal, January 2007

    • Ponce, Ana M.; Viglianti, Benjamin L.; Yu, Daohai
    • JNCI: Journal of the National Cancer Institute, Vol. 99, Issue 1
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    DNA cleavage by hydroxy-salicylidene-ethylendiamine-iron complexes
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    • Hergt, R.; Andra, W.; d'Ambly, C. G.
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    • DOI: 10.1109/20.718537

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    • Rezaee, Mohammad; Alizadeh, Elahe; Hunting, Darel
    • Bioinorganic Chemistry and Applications, Vol. 2012
    • DOI: 10.1155/2012/923914

    Fe(III)-Salen and Salphen Complexes Induce Caspase Activation and Apoptosis in Human Cells
    journal, January 2011

    • Ansari, Khairul I.; Kasiri, Sahba; Grant, James D.
    • Journal of Biomolecular Screening, Vol. 16, Issue 1
    • DOI: 10.1177/1087057110385227

    Reactive Oxygen Species, Cancer and Anti-Cancer Therapies
    journal, January 2009

    • Manda, Gina; Nechifor, Marina T.; Neagu, Teodora-Monica
    • Current Chemical Biology, Vol. 3, Issue 1
    • DOI: 10.2174/187231309787158271

    Magnetic nanoparticles and their applications in medicine
    journal, August 2006


    Therapeutic drug monitoring in cancer chemotherapy
    journal, May 2010

    • Bach, Dylan M.; Straseski, Joely A.; Clarke, William
    • Bioanalysis, Vol. 2, Issue 5
    • DOI: 10.4155/bio.10.48