Amyloid deposition as the central event in the aetiology of Alzheimer's disease
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journal
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January 1991 |
The APP family of proteins: similarities and differences
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journal
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March 2007 |
Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective
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journal
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February 2005 |
Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process
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journal
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April 2010 |
The -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential
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journal
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October 2009 |
BACE and γ-Secretase Characterization and Their Sorting as Therapeutic Targets to Reduce Amyloidogenesis
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journal
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September 2009 |
Additive Effects of PS1 and APP Mutations on Secretion of the 42-Residue Amyloid β-Protein
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journal
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August 1998 |
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
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July 2012 |
Structure-Based Design of β-Site APP Cleaving Enzyme 1 (BACE1) Inhibitors for the Treatment of Alzheimer’s Disease
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April 2013 |
Robust Central Reduction of Amyloid- in Humans with an Orally Available, Non-Peptidic -Secretase Inhibitor
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journal
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November 2011 |
Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design
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journal
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February 2015 |
Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States
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journal
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September 2011 |
Lipophilic efficiency: the most important efficiency metric in medicinal chemistry
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journal
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February 2013 |
Structural Modifications that Alter the P-Glycoprotein Efflux Properties of Compounds
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journal
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April 2012 |
Cerebrospinal Fluid Amyloid-β (Aβ) as an Effect Biomarker for Brain Aβ Lowering Verified by Quantitative Preclinical Analyses
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journal
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May 2012 |
Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors
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journal
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January 1997 |
Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance
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journal
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January 2012 |
Molecular genetics of CYP2D6: Clinical relevance with focus on psychotropic drugs: Molecular genetics of CYP2D6
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January 2002 |
hERG potassium channels and cardiac arrhythmia
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journal
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March 2006 |
A mechanistic link between an inherited and an acquird cardiac arrthytmia: HERG encodes the IKr potassium channel
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April 1995 |
Drug-Induced Prolongation of the QT Interval
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March 2004 |
A quantitative assessment of hERG liability as a function of lipophilicity
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March 2007 |
Core Refinement toward Permeable β-Secretase (BACE-1) Inhibitors with Low hERG Activity
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May 2013 |
Medicinal Chemistry of hERG Optimizations: Highlights and Hang-Ups
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August 2006 |
Overcoming hERG Affinity in the Discovery of Maraviroc; A CCR5 Antagonist for the Treatment of HIV
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September 2008 |
Predicting and Tuning Physicochemical Properties in Lead Optimization: Amine Basicities
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August 2007 |
A Practical Approach to the Synthesis of 2,4-Disubstituted Oxazoles from Amino Acids
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journal
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July 2002 |
Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-ray Crystallographic Analysis, and Biological Activities
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journal
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August 2002 |
Synthesis and Identification of a Novel 6,5,6-Tricyclic Lactam
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journal
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January 2003 |
Regiospecific Synthesis of 3-Substituted 5-Alkylisoxazoles from Oxime Dianions and N-Methoxy-N-Methylalkylamides
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September 1994 |
A Concise Synthesis of the Octalactins
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February 2004 |
Porphyrins with four azole substituents in meso positions: X-ray crystal structure of Meso-tetrakis-(1-benzylpyrazol-4-yl)-porphyrin at 200 K
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April 1995 |
Cembrane, synthesis. An advanced intermediate for crassin acetate.
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journal
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July 1991 |
Stereocontrolled transformations of orthoester intermediates into substituted tetrahydrofurans
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May 1984 |
New fluorinating reagents. Dialkylaminosulfur fluorides
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March 1975 |
Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments
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journal
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January 2008 |
Aminosulfur trifluorides: relative thermal stability [1]
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January 1989 |
Aminodifluorosulfinium Salts: Selective Fluorination Reagents with Enhanced Thermal Stability and Ease of Handling † , ‡
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May 2010 |
Synthesis of acyl halides under very mild conditions
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January 1979 |
?-Chloroenamines: New Reagents for Organic Synthesis
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September 1972 |
Thermal reactions of alkyl N-carbomethoxysulfamate esters
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January 1973 |
Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery
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January 2002 |
Characterization of Potassium Channel Modulators with QPatch ™ Automated Patch-Clamp Technology: System Characteristics and Performance
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journal
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October 2003 |
A novel approach to identifying β-secretase inhibitors: Bis-statine peptide mimetics discovered using structure and spot synthesis
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July 2006 |
[20] Processing of X-ray diffraction data collected in oscillation mode
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book
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January 1997 |
Refinement of Macromolecular Structures by the Maximum-Likelihood Method
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May 1997 |
Coot model-building tools for molecular graphics
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November 2004 |
XDS
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journal
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January 2010 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution
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journal
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January 2010 |
Structural alert/reactive metabolite concept as applied in medicinal chemistry to mitigate the risk of idiosyncratic drug toxicity: a perspective based on the critical examination of trends in the top 200 drugs marketed in the United States
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journal
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September 2011 |
Malate-Lactate Transhydrogenase
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journal
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September 1972 |
Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery
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journal
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January 2002 |
BACE and γ-Secretase Characterization and Their Sorting as Therapeutic Targets to Reduce Amyloidogenesis
|
journal
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September 2009 |
Twenty Years of the Alzheimer’s Disease Amyloid Hypothesis: A Genetic Perspective
|
journal
|
February 2005 |
Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-ray Crystallographic Analysis, and Biological Activities
|
journal
|
August 2002 |
Structural Modifications that Alter the P-Glycoprotein Efflux Properties of Compounds
|
journal
|
April 2012 |
Core Refinement toward Permeable β-Secretase (BACE-1) Inhibitors with Low hERG Activity
|
journal
|
May 2013 |
Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design
|
journal
|
February 2015 |
Aminodifluorosulfinium Salts: Selective Fluorination Reagents with Enhanced Thermal Stability and Ease of Handling † , ‡
|
journal
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May 2010 |
Crystal Structure of Human Cytochrome P450 2D6 with Prinomastat Bound
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journal
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March 2012 |
Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding
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journal
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February 2015 |
Characterization of Potassium Channel Modulators with QPatch ™ Automated Patch-Clamp Technology: System Characteristics and Performance
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journal
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October 2003 |
Cerebrospinal Fluid Amyloid-β (Aβ) as an Effect Biomarker for Brain Aβ Lowering Verified by Quantitative Preclinical Analyses
|
journal
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May 2012 |
PHENIX: a comprehensive Python-based system for macromolecular structure solution.
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text
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January 2010 |
Overcoming hERG Affinity in the Discovery of Maraviroc; A CCR5 Antagonist for the Treatment of HIV
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journal
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September 2008 |
Lipophilic efficiency: the most important efficiency metric in medicinal chemistry
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journal
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February 2013 |