Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation

Robison, Gregory; Sullivan, Brendan; Cannon, Jason R.; Pushkar, Yulia

doi:10.1039/C5MT00023H

Title: Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation

Authors:

Robison, Gregory ^[1]; Sullivan, Brendan ^[1]; Cannon, Jason R. ^[2]; Pushkar, Yulia ^[1]

Purdue Univ., West Lafayette, IN (United States). Dept. of Physics and Astronomy
Purdue Univ., West Lafayette, IN (United States). School of Health Sciences

Publication Date:: Wed Feb 11 00:00:00 EST 2015

Research Org.:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Org.:: USDOE Office of Science (SC); National Institutes of Health (NIH)

OSTI Identifier:: 1182302

Grant/Contract Number:: AC02-06CH11357

Resource Type:: Accepted Manuscript

Journal Name:: Metallomics

Additional Journal Information:: Journal Volume: 7; Journal Issue: 5; Journal ID: ISSN 1756-5901

Publisher:: Royal Society of Chemistry

Country of Publication:: United States

Language:: ENGLISH

Citation Formats


                    Robison, Gregory, Sullivan, Brendan, Cannon, Jason R., and Pushkar, Yulia. Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation.  United States: N. p., 2015. 
Web.  doi:10.1039/C5MT00023H.

Copy to clipboard


                    Robison, Gregory, Sullivan, Brendan, Cannon, Jason R., & Pushkar, Yulia. Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation.  United States.  https://doi.org/10.1039/C5MT00023H

Copy to clipboard


                    Robison, Gregory, Sullivan, Brendan, Cannon, Jason R., and Pushkar, Yulia. Wed .  
"Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation".  United States.  https://doi.org/10.1039/C5MT00023H.  https://www.osti.gov/servlets/purl/1182302.

Copy to clipboard


                    
@article{osti_1182302,

  title        = {Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation},

  author       = {Robison, Gregory and Sullivan, Brendan and Cannon, Jason R. and Pushkar, Yulia},

  abstractNote = {},

  doi          = {10.1039/C5MT00023H},

  journal      = {Metallomics},

  number       = 5,

  volume       = 7,

  place        = {United States},

  year         = {Wed Feb 11 00:00:00 EST 2015},

  month        = {Wed Feb 11 00:00:00 EST 2015}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (DOE)

Publisher's Version of Record

https://doi.org/10.1039/C5MT00023H

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 26 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Works referenced in this record:

Manganese toxicity upon overexposure
journal, November 2004

Crossgrove, Janelle; Zheng, Wei
NMR in Biomedicine, Vol. 17, Issue 8
DOI: 10.1002/nbm.931

Manganese-induced parkinsonism in methcathinone abusers: bio-markers of exposure and follow-up
journal, January 2013

Sikk, K.; Haldre, S.; Aquilonius, S. -M.
European Journal of Neurology, Vol. 20, Issue 6
DOI: 10.1111/ene.12088

Chronic Parkinsonism Associated With Cirrhosis: A Distinct Subset of Acquired Hepatocerebral Degeneration
journal, April 2003

Burkhard, Pierre R.; Delavelle, Jacqueline; Du Pasquier, Renaud
Archives of Neurology, Vol. 60, Issue 4
DOI: 10.1001/archneur.60.4.521

Relationship Between Changes in Brain MRI and ¹ H-MRS, Severity of Chronic Liver Damage, and Recovery After Liver Transplantation
journal, September 2009

Long, Li-Ling; Li, Xiang-Rong; Huang, Zhong-Kui
Experimental Biology and Medicine, Vol. 234, Issue 9
DOI: 10.3181/0903-RM-118

Manganese and Parkinson’s Disease: A Critical Review and New Findings
journal, August 2010

Guilarte, Tomás R.
Environmental Health Perspectives, Vol. 118, Issue 8
DOI: 10.1289/ehp.0901748

Manganese-Induced Parkinsonism and Parkinson's Disease
journal, March 2004

Olanow, C. W.
Annals of the New York Academy of Sciences, Vol. 1012, Issue 1
DOI: 10.1196/annals.1306.018

Are There Common Biochemical and Molecular Mechanisms Controlling Manganism and Parkisonism
journal, September 2009

Roth, Jerome A.
NeuroMolecular Medicine, Vol. 11, Issue 4
DOI: 10.1007/s12017-009-8088-8

A study of the relationships between Parkinson's disease and markers of traffic-derived and environmental manganese air pollution in two Canadian cities
journal, July 2007

Finkelstein, Murray M.; Jerrett, Michael
Environmental Research, Vol. 104, Issue 3
DOI: 10.1016/j.envres.2007.03.002

Multiple risk factors for Parkinson's disease
journal, February 2004

Gorell, Jay M.; Peterson, Edward L.; Rybicki, Benjamin A.
Journal of the Neurological Sciences, Vol. 217, Issue 2
DOI: 10.1016/j.jns.2003.09.014

High prevalence of parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries
journal, January 2007

Lucchini, Roberto G.; Albini, Elisa; Benedetti, Laura
American Journal of Industrial Medicine, Vol. 50, Issue 11
DOI: 10.1002/ajim.20494

Employment as a Welder and Parkinson Disease Among Heavy Equipment Manufacturing Workers
journal, January 2006

Marsh, Gary M.; Gula, Mary Jean
Journal of Occupational and Environmental Medicine, Vol. 48, Issue 10
DOI: 10.1097/01.jom.0000232547.74802.d8

Welding-related parkinsonism: Clinical features, treatment, and pathophysiology
journal, January 2001

Racette, B. A.; McGee-Minnich, L.; Moerlein, S. M.
Neurology, Vol. 56, Issue 1
DOI: 10.1212/WNL.56.1.8

State-of-the-Science Review: Does Manganese Exposure During Welding Pose a Neurological Risk?
journal, August 2007

Santamaria, Annette B.; Cushing, Colleen A.; Antonini, James M.
Journal of Toxicology and Environmental Health, Part B, Vol. 10, Issue 6
DOI: 10.1080/15287390600975004

Parkin attenuates manganese-induced dopaminergic cell death: Parkin in Mn-induced dopaminergic cell death
journal, May 2004

Higashi, Youichirou; Asanuma, Masato; Miyazaki, Ikuko
Journal of Neurochemistry, Vol. 89, Issue 6
DOI: 10.1111/j.1471-4159.2004.02445.x

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
journal, February 2009

Gitler, Aaron D.; Chesi, Alessandra; Geddie, Melissa L.
Nature Genetics, Vol. 41, Issue 3
DOI: 10.1038/ng.300

Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes
journal, December 2010

Sriram, Krishnan; Lin, Gary X.; Jefferson, Amy M.
The FASEB Journal, Vol. 24, Issue 12
DOI: 10.1096/fj.10-163964

Epidemiology and etiology of Parkinson’s disease: a review of the evidence
journal, May 2011

Wirdefeldt, Karin; Adami, Hans-Olov; Cole, Philip
European Journal of Epidemiology, Vol. 26, Issue S1
DOI: 10.1007/s10654-011-9581-6

Manganese Accumulates within Golgi Apparatus in Dopaminergic Cells as Revealed by Synchrotron X-ray Fluorescence Nanoimaging
journal, December 2009

Carmona, Asunción; Devès, Guillaume; Roudeau, Stéphane
ACS Chemical Neuroscience, Vol. 1, Issue 3
DOI: 10.1021/cn900021z

Environmental manganese compounds accumulate as Mn(ii) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity
journal, January 2014

Carmona, Asuncion; Roudeau, Stéphane; Perrin, Laura
Metallomics, Vol. 6, Issue 4
DOI: 10.1039/c4mt00012a

X-ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons
journal, December 2012

Dučić, Tanja; Barski, Elisabeth; Salome, Murielle
Journal of Neurochemistry, Vol. 124, Issue 2
DOI: 10.1111/jnc.12073

Manganese accumulates primarily in nuclei of cultured brain cells
journal, May 2008

Kalia, Kiran; Jiang, Wendy; Zheng, Wei
NeuroToxicology, Vol. 29, Issue 3
DOI: 10.1016/j.neuro.2008.02.012

Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia
journal, July 2009

Stanwood, Gregg D.; Leitch, Duncan B.; Savchenko, Valentina
Journal of Neurochemistry, Vol. 110, Issue 1
DOI: 10.1111/j.1471-4159.2009.06145.x

Visualizing manganese in the primate basal ganglia with magnetic resonance imaging
journal, December 1989

Newland, M. Christopher; Ceckler, Toni L.; Kordower, Jeffrey H.
Experimental Neurology, Vol. 106, Issue 3
DOI: 10.1016/0014-4886(89)90157-X

MRI and PET studies of manganese-intoxicated monkeys
journal, June 1995

Shinotoh, H.; Snow, B. J.; Hewitt, K. A.
Neurology, Vol. 45, Issue 6
DOI: 10.1212/WNL.45.6.1199

Manganese enhanced MRI in rat hippocampus: A correlative study with synchrotron X-ray microprobe
journal, January 2013

Daoust, A.; Barbier, E. L.; Bohic, S.
NeuroImage, Vol. 64
DOI: 10.1016/j.neuroimage.2012.09.025

X-Ray Fluorescence Imaging: A New Tool for Studying Manganese Neurotoxicity
journal, November 2012

Robison, Gregory; Zakharova, Taisiya; Fu, Sherleen
PLoS ONE, Vol. 7, Issue 11
DOI: 10.1371/journal.pone.0048899

X-ray fluorescence imaging of the hippocampal formation after manganese exposure
journal, January 2013

Robison, Gregory; Zakharova, Taisiya; Fu, Sherleen
Metallomics, Vol. 5, Issue 11
DOI: 10.1039/c3mt00133d

Ventral mesencephalic neurons containing both cholecystokinin- and tyrosine hydroxylase-like immunoreactivities project to forebrain regions
journal, January 1989

Seroogy, Kim B.; Dangaran, Karol; Lim, Steven
The Journal of Comparative Neurology, Vol. 279, Issue 3
DOI: 10.1002/cne.902790306

Microarray analysis of fluoro-gold labeled rat dopamine neurons harvested by laser capture microdissection
journal, April 2005

Yao, Fayi; Yu, Fei; Gong, Lijie
Journal of Neuroscience Methods, Vol. 143, Issue 2
DOI: 10.1016/j.jneumeth.2004.09.023

Zinc in DNA Replication and Transcription
journal, July 1987

Wu, F. Y. H.; Wu, C. W.
Annual Review of Nutrition, Vol. 7, Issue 1
DOI: 10.1146/annurev.nu.07.070187.001343

Alteration of iron homeostasis following chronic exposure to manganese in rats1Published on the World Wide Web on 10 May 1999.1
journal, June 1999

Zheng, Wei; Zhao, Qiuqu; Slavkovich, Vesna
Brain Research, Vol. 833, Issue 1
DOI: 10.1016/S0006-8993(99)01558-9

Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague–Dawley rats
journal, March 2009

Zheng, Wei; Jiang, Yue-Ming; Zhang, Yanshu
NeuroToxicology, Vol. 30, Issue 2
DOI: 10.1016/j.neuro.2008.12.007

Manganese intoxication and chronic liver failure
journal, December 1994

Hauser, Robert A.; Zesiewicz, Theresa A.; Rosemurgy, Alexander S.
Annals of Neurology, Vol. 36, Issue 6
DOI: 10.1002/ana.410360611

Inhibition of DAT function attenuates manganese accumulation in the globus pallidus
journal, March 2007

Anderson, Joel G.; Cooney, Paula T.; Erikson, Keith M.
Environmental Toxicology and Pharmacology, Vol. 23, Issue 2
DOI: 10.1016/j.etap.2006.08.006

Considerations on manganese (Mn) treatments for in vitro studies
journal, March 2014

Bowman, Aaron B.; Aschner, Michael
NeuroToxicology, Vol. 41
DOI: 10.1016/j.neuro.2014.01.010

The clearance of manganese chloride in the primate
journal, August 1987

Newland, M.
Fundamental and Applied Toxicology, Vol. 9, Issue 2
DOI: 10.1016/0272-0590(87)90054-6

Biological half-lives of zinc and manganese in rat brain
journal, October 1995

Takeda, Atsushi; Sawashita, Jinko; Okada, Shoji
Brain Research, Vol. 695, Issue 1
DOI: 10.1016/0006-8993(95)00916-E

Pharmacokinetics of Inhaled Manganese Phosphate in Male Sprague–Dawley Rats Following Subacute (14-Day) Exposure
journal, March 2000

Vitarella, Domenico; Wong, Brian A.; Moss, Owen R.
Toxicology and Applied Pharmacology, Vol. 163, Issue 3
DOI: 10.1006/taap.1999.8874

Hepatic subcellular distribution of manganese in manganese and manganese-bilirubin induced cholestasis
journal, November 1985

Ayotte, Pierre; Plaa, Gabriel L.
Biochemical Pharmacology, Vol. 34, Issue 21
DOI: 10.1016/0006-2952(85)90435-6

Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats
journal, January 2008

Morello, M.; Canini, A.; Mattioli, P.
NeuroToxicology, Vol. 29, Issue 1
DOI: 10.1016/j.neuro.2007.09.001

β-Cell subcellular localization of glucose-stimulated Mn uptake by X-ray fluorescence microscopy: implications for pancreatic MRI: β-CELL SUBCELLULAR LOCALIZATION OF MANGANESE UPTAKE BY XFM
journal, November 2011

Leoni, Lara; Dhyani, Anita; La Riviere, Patrick
Contrast Media & Molecular Imaging, Vol. 6, Issue 6
DOI: 10.1002/cmmi.447

Effects of Manganese on Extracellular Levels of Dopamine in Rat Striatum: An Analysis In vivo by Brain Microdialysis
journal, September 2005

Vidal, L.; Alfonso, M.; Campos, F.
Neurochemical Research, Vol. 30, Issue 9
DOI: 10.1007/s11064-005-7775-6

Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism
journal, December 2008

Guilarte, Tomás R.; Burton, Neal C.; McGlothan, Jennifer L.
Journal of Neurochemistry, Vol. 107, Issue 5
DOI: 10.1111/j.1471-4159.2008.05695.x

Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates
journal, December 2006

Guilarte, T.; Chen, M.; Mcglothan, J.
Experimental Neurology, Vol. 202, Issue 2
DOI: 10.1016/j.expneurol.2006.06.015

Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes
journal, June 2008

McDougall, S. A.; Reichel, C. M.; Farley, C. M.
Neuroscience, Vol. 154, Issue 2
DOI: 10.1016/j.neuroscience.2008.03.070

Manganese mixture inhalation is a reliable Parkinson disease model in rats
journal, October 2012

Sanchez-Betancourt, Javier; Anaya-Martínez, Veronica; Gutierrez-Valdez, Ana Luisa
NeuroToxicology, Vol. 33, Issue 5
DOI: 10.1016/j.neuro.2012.08.012

Enhancing Effect of Manganese on L-DOPA-Induced Apoptosis in PC12 Cells: Role of Oxidative Stress
journal, September 1999

Migheli, Rossana; Godani, Chiara; Sciola, Luigi
Journal of Neurochemistry, Vol. 73, Issue 3
DOI: 10.1046/j.1471-4159.1999.0731155.x

Manganese increases L-DOPA auto-oxidation in the striatum of the freely moving rat: potential implications to L-DOPA long-term therapy of Parkinson's disease: Manganese and L-DOPA auto-oxidation in vivo
journal, June 2000

Serra, Pier Andrea; Esposito, Giovanni; Enrico, Paolo
British Journal of Pharmacology, Vol. 130, Issue 4
DOI: 10.1038/sj.bjp.0703379

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans
journal, August 2010

Benedetto, Alexandre; Au, Catherine; Avila, Daiana Silva
PLoS Genetics, Vol. 6, Issue 8
DOI: 10.1371/journal.pgen.1001084

Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra
journal, November 1997

Hersch, Steven M.; Yi, Hong; Heilman, Craig J.
The Journal of Comparative Neurology, Vol. 388, Issue 2
DOI: 10.1002/(SICI)1096-9861(19971117)388:2<211::AID-CNE3>3.0.CO;2-4

Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter
journal, November 2005

Erikson, Keith M.; John, Carrie E.; Jones, Sara R.
Environmental Toxicology and Pharmacology, Vol. 20, Issue 3
DOI: 10.1016/j.etap.2005.03.009

Works referencing / citing this record:

GLAST Activity is Modified by Acute Manganese Exposure in Bergmann Glial Cells
journal, July 2019

Escalante, Miguel; Soto-Verdugo, Jazmín; Hernández-Kelly, Luisa C.
Neurochemical Research, Vol. 45, Issue 6
DOI: 10.1007/s11064-019-02848-8

“Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies”
journal, November 2016

Peres, Tanara V.; Schettinger, Maria Rosa C.; Chen, Pan
BMC Pharmacology and Toxicology, Vol. 17, Issue 1
DOI: 10.1186/s40360-016-0099-0

Metals and Neurodegeneration
journal, January 2016

Chen, Pan; Miah, Mahfuzur Rahman; Aschner, Michael
F1000Research, Vol. 5
DOI: 10.12688/f1000research.7431.1

Mapping Chemical Elements and Iron Oxidation States in the Substantia Nigra of 6-Hydroxydopamine Lesioned Rats Using Correlative Immunohistochemistry With Proton and Synchrotron Micro-Analysis
journal, September 2019

Carmona, Asuncion; Roudeau, Stéphane; Perrin, Laura
Frontiers in Neuroscience, Vol. 13
DOI: 10.3389/fnins.2019.01014

Metals and Neurodegeneration
book, January 2012

Crichton, Robert R.
Biological Inorganic Chemistry
DOI: 10.1016/b978-0-444-53782-9.00021-8

Metals and neurodegeneration
journal, September 2015

Aizenman, Elias; Mastroberardino, Pier G.
Neurobiology of Disease, Vol. 81
DOI: 10.1016/j.nbd.2015.08.012

Similar Records in DOE PAGES and OSTI.GOV collections:

Differential ultrastructural alterations in the Vglut2 glutamatergic input to the substantia nigra pars compacta/pars reticulata following nigrostriatal dopamine loss in a progressive mouse model of Parkinson’s disease

Journal Article Moore, Cynthia ; Xu, Mo ; Bohlen, Jerry K. ; ... - European Journal of Neuroscience

Abstract Loss of nigrostriatal dopamine (DA) in Parkinson's disease results in over‐activation/bursting of the subthalamic nucleus (STN). The STN projects to the substantia nigra (SN) pars compacta (SNpc) and pars reticulata (SNpr). The vesicular glutamate transporter 2 (Vglut2) is localized within at least STN terminals synapsing within the SN, but it is not known if there are differential changes in the Vglut2+ input to the SNpc versus SNpr following DA loss. The goal/rationale of this current study was to determine whether there were differential changes in the density/levels of glutamate immuno‐gold labeling within Vglut2+ nerve terminals synapsing in the SNpc/SNprmore »« less
https://doi.org/10.1111/ejn.14894
Proteomic Profiling of the Substantia Nigra to Identify Determinants of Lewy Body Pathology and Dopaminergic Neuronal Loss

Journal Article Petyuk, Vladislav A. ; Yu, Lei ; Olson, Heather M. ; ... - Journal of Proteome Research

Proteinaceous aggregates containing ?-synuclein protein called Lewy bodies in the substantia nigra is a hallmark of Parkinson’s disease. The molecular mechanisms of Lewy body formation and associated neuronal loss remain largely unknown. To gain insights on proteins and pathways associated with Lewy body pathology, we performed quantitative profiling of the proteome. We analyzed substantia nigra tissue from 51 subjects arranged into three groups: cases with Lewy body pathology, Lewy body-negative controls with matching neuronal loss and controls with no neuronal loss. Using label-free LC-MS/MS approach we quantified the 2,963 most abundant proteins. Statistical testing for differential protein abundance, followed bymore »« less
https://doi.org/10.1021/acs.jproteome.0c00747
Manganese nanoparticle activates mitochondrial dependent apoptotic signaling and autophagy in dopaminergic neuronal cells

Journal Article Afeseh Ngwa, Hilary ; Kanthasamy, Arthi ; Gu, Yan ; ... - Toxicology and Applied Pharmacology

The production of man-made nanoparticles for various modern applications has increased exponentially in recent years, but the potential health effects of most nanoparticles are not well characterized. Unfortunately, in vitro nanoparticle toxicity studies are extremely limited by yet unresolved problems relating to dosimetry. In the present study, we systematically characterized manganese (Mn) nanoparticle sizes and examined the nanoparticle-induced oxidative signaling in dopaminergic neuronal cells. Differential interference contrast (DIC) microscopy and transmission electron microscopy (TEM) studies revealed that Mn nanoparticles range in size from single nanoparticles ({approx} 25 nM) to larger agglomerates when in treatment media. Manganese nanoparticles were effectively internalizedmore »« less
https://doi.org/10.1016/J.TAAP.2011.07.018
COMPARATIVE ELECTRONOPTIC STUDY OF THE SUBSTANTIA COMPACTA OF THE TIBIAL DIAPHYSIS OF NORMAL, STRONTIUM-PSEUDORACHITIC AND RACHITIC RATS, AND OF A RACHITIC CHILD WHO HAD DIED IN TETANY (in German)

Journal Article Wilhelm, G ; Lippert, G - Monatsschr. Kinderheilk.
Functional Connectivity of Substantia Nigra and Ventral Tegmental Area: Maturation During Adolescence and Effects of ADHD

Journal Article Tomasi, D. ; Tomasi, D. ; Volkow, N. D. - CEREBRAL CORTEX

Similar Records

Title: Identification of dopaminergic neurons of the substantia nigra pars compacta as a target of manganese accumulation

Citation Formats

Manganese toxicity upon overexposure journal, November 2004

Manganese-induced parkinsonism in methcathinone abusers: bio-markers of exposure and follow-up journal, January 2013

Chronic Parkinsonism Associated With Cirrhosis: A Distinct Subset of Acquired Hepatocerebral Degeneration journal, April 2003

Relationship Between Changes in Brain MRI and 1 H-MRS, Severity of Chronic Liver Damage, and Recovery After Liver Transplantation journal, September 2009

Manganese and Parkinson’s Disease: A Critical Review and New Findings journal, August 2010

Manganese-Induced Parkinsonism and Parkinson's Disease journal, March 2004

Are There Common Biochemical and Molecular Mechanisms Controlling Manganism and Parkisonism journal, September 2009

A study of the relationships between Parkinson's disease and markers of traffic-derived and environmental manganese air pollution in two Canadian cities journal, July 2007

Multiple risk factors for Parkinson's disease journal, February 2004

High prevalence of parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries journal, January 2007

Employment as a Welder and Parkinson Disease Among Heavy Equipment Manufacturing Workers journal, January 2006

Welding-related parkinsonism: Clinical features, treatment, and pathophysiology journal, January 2001

State-of-the-Science Review: Does Manganese Exposure During Welding Pose a Neurological Risk? journal, August 2007

Parkin attenuates manganese-induced dopaminergic cell death: Parkin in Mn-induced dopaminergic cell death journal, May 2004

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity journal, February 2009

Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes journal, December 2010

Epidemiology and etiology of Parkinson’s disease: a review of the evidence journal, May 2011

Manganese Accumulates within Golgi Apparatus in Dopaminergic Cells as Revealed by Synchrotron X-ray Fluorescence Nanoimaging journal, December 2009

Environmental manganese compounds accumulate as Mn(ii) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity journal, January 2014

X-ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons journal, December 2012

Manganese accumulates primarily in nuclei of cultured brain cells journal, May 2008

Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia journal, July 2009

Visualizing manganese in the primate basal ganglia with magnetic resonance imaging journal, December 1989

MRI and PET studies of manganese-intoxicated monkeys journal, June 1995

Manganese enhanced MRI in rat hippocampus: A correlative study with synchrotron X-ray microprobe journal, January 2013

X-Ray Fluorescence Imaging: A New Tool for Studying Manganese Neurotoxicity journal, November 2012

X-ray fluorescence imaging of the hippocampal formation after manganese exposure journal, January 2013

Ventral mesencephalic neurons containing both cholecystokinin- and tyrosine hydroxylase-like immunoreactivities project to forebrain regions journal, January 1989

Microarray analysis of fluoro-gold labeled rat dopamine neurons harvested by laser capture microdissection journal, April 2005

Zinc in DNA Replication and Transcription journal, July 1987

Alteration of iron homeostasis following chronic exposure to manganese in rats1Published on the World Wide Web on 10 May 1999.1 journal, June 1999

Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague–Dawley rats journal, March 2009

Manganese intoxication and chronic liver failure journal, December 1994

Inhibition of DAT function attenuates manganese accumulation in the globus pallidus journal, March 2007

Considerations on manganese (Mn) treatments for in vitro studies journal, March 2014

The clearance of manganese chloride in the primate journal, August 1987

Biological half-lives of zinc and manganese in rat brain journal, October 1995

Pharmacokinetics of Inhaled Manganese Phosphate in Male Sprague–Dawley Rats Following Subacute (14-Day) Exposure journal, March 2000

Hepatic subcellular distribution of manganese in manganese and manganese-bilirubin induced cholestasis journal, November 1985

Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats journal, January 2008

β-Cell subcellular localization of glucose-stimulated Mn uptake by X-ray fluorescence microscopy: implications for pancreatic MRI: β-CELL SUBCELLULAR LOCALIZATION OF MANGANESE UPTAKE BY XFM journal, November 2011

Effects of Manganese on Extracellular Levels of Dopamine in Rat Striatum: An Analysis In vivo by Brain Microdialysis journal, September 2005

Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism journal, December 2008

Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates journal, December 2006

Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes journal, June 2008

Manganese mixture inhalation is a reliable Parkinson disease model in rats journal, October 2012

Enhancing Effect of Manganese on L-DOPA-Induced Apoptosis in PC12 Cells: Role of Oxidative Stress journal, September 1999

Manganese increases L-DOPA auto-oxidation in the striatum of the freely moving rat: potential implications to L-DOPA long-term therapy of Parkinson's disease: Manganese and L-DOPA auto-oxidation in vivo journal, June 2000

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans journal, August 2010

Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra journal, November 1997

Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter journal, November 2005

GLAST Activity is Modified by Acute Manganese Exposure in Bergmann Glial Cells journal, July 2019

“Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies” journal, November 2016

Metals and Neurodegeneration journal, January 2016

Mapping Chemical Elements and Iron Oxidation States in the Substantia Nigra of 6-Hydroxydopamine Lesioned Rats Using Correlative Immunohistochemistry With Proton and Synchrotron Micro-Analysis journal, September 2019

Metals and Neurodegeneration book, January 2012

Metals and neurodegeneration journal, September 2015

Manganese toxicity upon overexposure
journal, November 2004

Manganese-induced parkinsonism in methcathinone abusers: bio-markers of exposure and follow-up
journal, January 2013

Chronic Parkinsonism Associated With Cirrhosis: A Distinct Subset of Acquired Hepatocerebral Degeneration
journal, April 2003

Relationship Between Changes in Brain MRI and ¹ H-MRS, Severity of Chronic Liver Damage, and Recovery After Liver Transplantation
journal, September 2009

Manganese and Parkinson’s Disease: A Critical Review and New Findings
journal, August 2010

Manganese-Induced Parkinsonism and Parkinson's Disease
journal, March 2004

Are There Common Biochemical and Molecular Mechanisms Controlling Manganism and Parkisonism
journal, September 2009

A study of the relationships between Parkinson's disease and markers of traffic-derived and environmental manganese air pollution in two Canadian cities
journal, July 2007

Multiple risk factors for Parkinson's disease
journal, February 2004

High prevalence of parkinsonian disorders associated to manganese exposure in the vicinities of ferroalloy industries
journal, January 2007

Employment as a Welder and Parkinson Disease Among Heavy Equipment Manufacturing Workers
journal, January 2006

Welding-related parkinsonism: Clinical features, treatment, and pathophysiology
journal, January 2001

State-of-the-Science Review: Does Manganese Exposure During Welding Pose a Neurological Risk?
journal, August 2007

Parkin attenuates manganese-induced dopaminergic cell death: Parkin in Mn-induced dopaminergic cell death
journal, May 2004

α-Synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity
journal, February 2009

Mitochondrial dysfunction and loss of Parkinson's disease-linked proteins contribute to neurotoxicity of manganese-containing welding fumes
journal, December 2010

Epidemiology and etiology of Parkinson’s disease: a review of the evidence
journal, May 2011

Manganese Accumulates within Golgi Apparatus in Dopaminergic Cells as Revealed by Synchrotron X-ray Fluorescence Nanoimaging
journal, December 2009

Environmental manganese compounds accumulate as Mn(ii) within the Golgi apparatus of dopamine cells: relationship between speciation, subcellular distribution, and cytotoxicity
journal, January 2014

X-ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons
journal, December 2012

Manganese accumulates primarily in nuclei of cultured brain cells
journal, May 2008

Manganese exposure is cytotoxic and alters dopaminergic and GABAergic neurons within the basal ganglia
journal, July 2009

Visualizing manganese in the primate basal ganglia with magnetic resonance imaging
journal, December 1989

MRI and PET studies of manganese-intoxicated monkeys
journal, June 1995

Manganese enhanced MRI in rat hippocampus: A correlative study with synchrotron X-ray microprobe
journal, January 2013

X-Ray Fluorescence Imaging: A New Tool for Studying Manganese Neurotoxicity
journal, November 2012

X-ray fluorescence imaging of the hippocampal formation after manganese exposure
journal, January 2013

Ventral mesencephalic neurons containing both cholecystokinin- and tyrosine hydroxylase-like immunoreactivities project to forebrain regions
journal, January 1989

Microarray analysis of fluoro-gold labeled rat dopamine neurons harvested by laser capture microdissection
journal, April 2005

Zinc in DNA Replication and Transcription
journal, July 1987

Alteration of iron homeostasis following chronic exposure to manganese in rats1Published on the World Wide Web on 10 May 1999.1
journal, June 1999

Chelation therapy of manganese intoxication with para-aminosalicylic acid (PAS) in Sprague–Dawley rats
journal, March 2009

Manganese intoxication and chronic liver failure
journal, December 1994

Inhibition of DAT function attenuates manganese accumulation in the globus pallidus
journal, March 2007

Considerations on manganese (Mn) treatments for in vitro studies
journal, March 2014

The clearance of manganese chloride in the primate
journal, August 1987

Biological half-lives of zinc and manganese in rat brain
journal, October 1995

Pharmacokinetics of Inhaled Manganese Phosphate in Male Sprague–Dawley Rats Following Subacute (14-Day) Exposure
journal, March 2000

Hepatic subcellular distribution of manganese in manganese and manganese-bilirubin induced cholestasis
journal, November 1985

Sub-cellular localization of manganese in the basal ganglia of normal and manganese-treated rats
journal, January 2008

β-Cell subcellular localization of glucose-stimulated Mn uptake by X-ray fluorescence microscopy: implications for pancreatic MRI: β-CELL SUBCELLULAR LOCALIZATION OF MANGANESE UPTAKE BY XFM
journal, November 2011

Effects of Manganese on Extracellular Levels of Dopamine in Rat Striatum: An Analysis In vivo by Brain Microdialysis
journal, September 2005

Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre-synaptic mechanism(s): implications to manganese-induced parkinsonism
journal, December 2008

Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates
journal, December 2006

Postnatal manganese exposure alters dopamine transporter function in adult rats: Potential impact on nonassociative and associative processes
journal, June 2008

Manganese mixture inhalation is a reliable Parkinson disease model in rats
journal, October 2012

Enhancing Effect of Manganese on L-DOPA-Induced Apoptosis in PC12 Cells: Role of Oxidative Stress
journal, September 1999

Manganese increases L-DOPA auto-oxidation in the striatum of the freely moving rat: potential implications to L-DOPA long-term therapy of Parkinson's disease: Manganese and L-DOPA auto-oxidation in vivo
journal, June 2000

Extracellular Dopamine Potentiates Mn-Induced Oxidative Stress, Lifespan Reduction, and Dopaminergic Neurodegeneration in a BLI-3–Dependent Manner in Caenorhabditis elegans
journal, August 2010

Subcellular localization and molecular topology of the dopamine transporter in the striatum and substantia nigra
journal, November 1997

Manganese accumulation in striatum of mice exposed to toxic doses is dependent upon a functional dopamine transporter
journal, November 2005

GLAST Activity is Modified by Acute Manganese Exposure in Bergmann Glial Cells
journal, July 2019

“Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies”
journal, November 2016

Metals and Neurodegeneration
journal, January 2016

Mapping Chemical Elements and Iron Oxidation States in the Substantia Nigra of 6-Hydroxydopamine Lesioned Rats Using Correlative Immunohistochemistry With Proton and Synchrotron Micro-Analysis
journal, September 2019

Metals and Neurodegeneration
book, January 2012

Metals and neurodegeneration
journal, September 2015