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Title: High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

Authors:
 [1] ;  [2] ;  [1] ;  [3] ;  [1] ;  [1] ;  [3] ;  [2] ;  [1] ;  [2] ;  [1]
  1. Department of Pathology, University of Michigan, Ann Arbor, 1150 West Medical Center Drive, MSRBI, Room 4510D, Michigan, 48109, United States
  2. Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States, Vanderbilt Specialized Chemistry Center for Probe Development (MLPCN), Nashville, Tennessee 37232, United States, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States, Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, United States
  3. Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States, Vanderbilt Specialized Chemistry Center for Probe Development (MLPCN), Nashville, Tennessee 37232, United States, Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States
Publication Date:
Grant/Contract Number:
AC02-06CH11357
Type:
Published Article
Journal Name:
Journal of Medicinal Chemistry
Additional Journal Information:
Journal Volume: 57; Journal Issue: 4; Related Information: CHORUS Timestamp: 2017-11-09 11:35:21; Journal ID: ISSN 0022-2623
Publisher:
American Chemical Society
Sponsoring Org:
USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)
Country of Publication:
United States
Language:
English
OSTI Identifier:
1168873