Rectangular Ion Funnel: A New Ion Funnel Interface for Structures for Lossless Ion Manipulations

Chen, Tsung-Chi; Webb, Ian K.; Prost, Spencer A.; Harrer, Marques B.; Norheim, Randolph V.; Tang, Keqi; Ibrahim, Yehia M.; Smith, Richard D.

doi:10.1021/ac503564c

Title: Rectangular Ion Funnel: A New Ion Funnel Interface for Structures for Lossless Ion Manipulations

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Abstract

A recent achievement in Structures for Lossless Ion Manipulations (SLIM) is the ability for near lossless ion focusing, transfer, and trapping in sub-atmospheric pressure regions. While lossless ion manipulations are advantageously applied to the applications of ion mobility separations and gas phase reactions, ion introduction through ring electrode ion funnels or more conventional ion optics to SLIM can involve discontinuities in electric fields or other perturbations that result in ion losses. In this work, we investigated a new funnel design that aims to seamlessly couple to SLIM at the funnel exit. This rectangular ion funnel (RIF) was initially evaluated by ion simulations, fabricated utilizing printed circuit board technology and tested experimentally. The RIF was integrated to a SLIM-TOFMS system, and the operating parameters, including RF, DC bias of the RIF electrodes, and electric fields for effectively interfacing with a SLIM were characterized. The RIF provided a 2-fold sensitivity increase without significant discrimination over a wide m/z range along with greatly improved SLIM operational stability.

Authors:

Chen, Tsung-Chi ^[1]; Webb, Ian K. ^[1]; Prost, Spencer A. ^[1]; Harrer, Marques B. ^[1]; Norheim, Randolph V. ^[1]; Tang, Keqi ^[1]; Ibrahim, Yehia M. ^[1]; Smith, Richard D. ^[1]

Biological Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99352, United States

Publication Date:: Mon Dec 08 00:00:00 EST 2014

Research Org.:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:: USDOE Office of Science (SC), Biological and Environmental Research (BER)

OSTI Identifier:: 1165165

Alternate Identifier(s):: OSTI ID: 1170044

Report Number(s):: PNNL-SA-105304
Journal ID: ISSN 0003-2700

Grant/Contract Number:: AC05-76RL01830; P41 GM103493

Resource Type:: Published Article

Journal Name:: Analytical Chemistry

Additional Journal Information:: Journal Name: Analytical Chemistry Journal Volume: 87 Journal Issue: 1; Journal ID: ISSN 0003-2700

Publisher:: American Chemical Society

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY; Lossless Ion Manipulations; rectangular ion funnel (RIF); Environmental Molecular Sciences Laboratory

Citation Formats


                    Chen, Tsung-Chi, Webb, Ian K., Prost, Spencer A., Harrer, Marques B., Norheim, Randolph V., Tang, Keqi, Ibrahim, Yehia M., and Smith, Richard D. Rectangular Ion Funnel: A New Ion Funnel Interface for Structures for Lossless Ion Manipulations.  United States: N. p., 2014. 
Web.  doi:10.1021/ac503564c.

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                    Chen, Tsung-Chi, Webb, Ian K., Prost, Spencer A., Harrer, Marques B., Norheim, Randolph V., Tang, Keqi, Ibrahim, Yehia M., & Smith, Richard D. Rectangular Ion Funnel: A New Ion Funnel Interface for Structures for Lossless Ion Manipulations.  United States.  https://doi.org/10.1021/ac503564c

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                    Chen, Tsung-Chi, Webb, Ian K., Prost, Spencer A., Harrer, Marques B., Norheim, Randolph V., Tang, Keqi, Ibrahim, Yehia M., and Smith, Richard D. Mon .  
"Rectangular Ion Funnel: A New Ion Funnel Interface for Structures for Lossless Ion Manipulations".  United States.  https://doi.org/10.1021/ac503564c.

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@article{osti_1165165,

  title        = {Rectangular Ion Funnel: A New Ion Funnel Interface for Structures for Lossless Ion Manipulations},

  author       = {Chen, Tsung-Chi and Webb, Ian K. and Prost, Spencer A. and Harrer, Marques B. and Norheim, Randolph V. and Tang, Keqi and Ibrahim, Yehia M. and Smith, Richard D.},

  abstractNote = {A recent achievement in Structures for Lossless Ion Manipulations (SLIM) is the ability for near lossless ion focusing, transfer, and trapping in sub-atmospheric pressure regions. While lossless ion manipulations are advantageously applied to the applications of ion mobility separations and gas phase reactions, ion introduction through ring electrode ion funnels or more conventional ion optics to SLIM can involve discontinuities in electric fields or other perturbations that result in ion losses. In this work, we investigated a new funnel design that aims to seamlessly couple to SLIM at the funnel exit. This rectangular ion funnel (RIF) was initially evaluated by ion simulations, fabricated utilizing printed circuit board technology and tested experimentally. The RIF was integrated to a SLIM-TOFMS system, and the operating parameters, including RF, DC bias of the RIF electrodes, and electric fields for effectively interfacing with a SLIM were characterized. The RIF provided a 2-fold sensitivity increase without significant discrimination over a wide m/z range along with greatly improved SLIM operational stability.},

  doi          = {10.1021/ac503564c},

  journal      = {Analytical Chemistry},

  number       = 1,

  volume       = 87,

  place        = {United States},

  year         = {Mon Dec 08 00:00:00 EST 2014},

  month        = {Mon Dec 08 00:00:00 EST 2014}

}

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