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Title: Human Translation Initiation Factor eIF4G1 Possesses a Low-Affinity ATP Binding Site Facing the ATP-Binding Cleft of eIF4A in the eIF4G/eIF4A Complex

Authors:
 [1];  [2];  [1]
  1. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, United States
  2. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Avenue, Boston, Massachusetts 02115, United States, Department of Chemistry, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel
Publication Date:
Sponsoring Org.:
USDOE Office of Science (SC), Basic Energy Sciences (BES)
OSTI Identifier:
1160154
Grant/Contract Number:  
AC02-98CH10886
Resource Type:
Published Article
Journal Name:
Biochemistry
Additional Journal Information:
Journal Name: Biochemistry Journal Volume: 53 Journal Issue: 41; Journal ID: ISSN 0006-2960
Publisher:
American Chemical Society
Country of Publication:
United States
Language:
English

Citation Formats

Akabayov, Sabine R., Akabayov, Barak, and Wagner, Gerhard. Human Translation Initiation Factor eIF4G1 Possesses a Low-Affinity ATP Binding Site Facing the ATP-Binding Cleft of eIF4A in the eIF4G/eIF4A Complex. United States: N. p., 2014. Web. doi:10.1021/bi500600m.
Akabayov, Sabine R., Akabayov, Barak, & Wagner, Gerhard. Human Translation Initiation Factor eIF4G1 Possesses a Low-Affinity ATP Binding Site Facing the ATP-Binding Cleft of eIF4A in the eIF4G/eIF4A Complex. United States. https://doi.org/10.1021/bi500600m
Akabayov, Sabine R., Akabayov, Barak, and Wagner, Gerhard. Wed . "Human Translation Initiation Factor eIF4G1 Possesses a Low-Affinity ATP Binding Site Facing the ATP-Binding Cleft of eIF4A in the eIF4G/eIF4A Complex". United States. https://doi.org/10.1021/bi500600m.
@article{osti_1160154,
title = {Human Translation Initiation Factor eIF4G1 Possesses a Low-Affinity ATP Binding Site Facing the ATP-Binding Cleft of eIF4A in the eIF4G/eIF4A Complex},
author = {Akabayov, Sabine R. and Akabayov, Barak and Wagner, Gerhard},
abstractNote = {},
doi = {10.1021/bi500600m},
journal = {Biochemistry},
number = 41,
volume = 53,
place = {United States},
year = {Wed Oct 08 00:00:00 EDT 2014},
month = {Wed Oct 08 00:00:00 EDT 2014}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record
https://doi.org/10.1021/bi500600m

Citation Metrics:
Cited by: 2 works
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Works referenced in this record:

ATHENA , ARTEMIS , HEPHAESTUS : data analysis for X-ray absorption spectroscopy using IFEFFIT
journal, June 2005


Translation initiation: structures, mechanisms and evolution
journal, November 2004


Molecular Crowding Enhanced ATPase Activity of the RNA Helicase eIF4A Correlates with Compaction of Its Quaternary Structure and Association with eIF4G
journal, June 2013

  • Akabayov, Sabine R.; Akabayov, Barak; Richardson, Charles C.
  • Journal of the American Chemical Society, Vol. 135, Issue 27
  • DOI: 10.1021/ja404404h

A Conserved HEAT Domain within eIF4G Directs Assembly of the Translation Initiation Machinery
journal, January 2001


Crystal structure of the eIF4A-PDCD4 complex
journal, February 2009

  • Chang, J. H.; Cho, Y. H.; Sohn, S. Y.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 9
  • DOI: 10.1073/pnas.0808275106

Characterization of eukaryotic initiation factor 4A, a protein involved in ATP-dependent binding of globin mRNA.
journal, May 1982


Purification and Characterization of a New Eukaryotic Protein Translation Factor
journal, March 1998

  • Richter-Cook, Nancy J.; Dever, Thomas E.; Hensold, Jack O.
  • Journal of Biological Chemistry, Vol. 273, Issue 13
  • DOI: 10.1074/jbc.273.13.7579

Coupled Folding during Translation Initiation
journal, December 2003


Direct functional interaction of initiation factor eIF4G with type 1 internal ribosomal entry sites
journal, May 2009

  • de Breyne, S.; Yu, Y.; Unbehaun, A.
  • Proceedings of the National Academy of Sciences, Vol. 106, Issue 23
  • DOI: 10.1073/pnas.0900153106

Bent out of Shape: RNA Unwinding by the DEAD-Box Helicase Vasa
journal, April 2006


The ATPase Cycle Mechanism of the DEAD-box rRNA Helicase, DbpA
journal, March 2008

  • Henn, Arnon; Cao, Wenxiang; Hackney, David D.
  • Journal of Molecular Biology, Vol. 377, Issue 1
  • DOI: 10.1016/j.jmb.2007.12.046

eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism
journal, November 2010

  • Hilbert, Manuel; Kebbel, Fabian; Gubaev, Airat
  • Nucleic Acids Research, Vol. 39, Issue 6
  • DOI: 10.1093/nar/gkq1127

Helicases: amino acid sequence comparisons and structure-function relationships
journal, June 1993


Interaction between the NH2-terminal Domain of eIF4A and the Central Domain of eIF4G Modulates RNA-stimulated ATPase Activity
journal, January 2005

  • Korneeva, Nadia L.; First, Eric A.; Benoit, Clint A.
  • Journal of Biological Chemistry, Vol. 280, Issue 3
  • DOI: 10.1074/jbc.M406168200

The ATP-dependent interaction of eukaryotic initiation factors with mRNA.
journal, March 1987


Crystal structure of the yeast eIF4A-eIF4G complex: An RNA-helicase controlled by protein-protein interactions
journal, July 2008

  • Schutz, P.; Bumann, M.; Oberholzer, A. E.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 28
  • DOI: 10.1073/pnas.0800418105

Backbone resonance assignment of the HEAT1-domain of the human eukaryotic translation initiation factor 4GI
journal, January 2013


Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation
journal, February 2009


mRNA helicases: the tacticians of translational control
journal, March 2011

  • Parsyan, Armen; Svitkin, Yuri; Shahbazian, David
  • Nature Reviews Molecular Cell Biology, Vol. 12, Issue 4
  • DOI: 10.1038/nrm3083

RNA-stimulated ATPase activity of eukaryotic initiation factors.
journal, July 1984


NMRPipe: A multidimensional spectral processing system based on UNIX pipes
journal, November 1995

  • Delaglio, Frank; Grzesiek, Stephan; Vuister, GeertenW.
  • Journal of Biomolecular NMR, Vol. 6, Issue 3
  • DOI: 10.1007/BF00197809

DNA Recognition by the DNA Primase of Bacteriophage T7: A Structure−Function Study of the Zinc-Binding Domain
journal, February 2009

  • Akabayov, Barak; Lee, Seung-Joo; Akabayov, Sabine R.
  • Biochemistry, Vol. 48, Issue 8
  • DOI: 10.1021/bi802123t

Crystal structure of yeast initiation factor 4A, a DEAD-box RNA helicase
journal, November 2000

  • Caruthers, J. M.; Johnson, E. R.; McKay, D. B.
  • Proceedings of the National Academy of Sciences, Vol. 97, Issue 24
  • DOI: 10.1073/pnas.97.24.13080

Birth of the D-E-A-D box
journal, January 1989

  • Linder, Patrick; Lasko, Paul F.; Ashburner, Michael
  • Nature, Vol. 337, Issue 6203
  • DOI: 10.1038/337121a0

Structural basis for the enhancement of eIF4A helicase activity by eIF4G
journal, September 2005


The Molecular Mechanics of Eukaryotic Translation
journal, June 2004


Binding of Mn-deoxyribonucleoside triphosphates to the active site of the DNA polymerase of bacteriophage T7
journal, June 2011

  • Akabayov, Barak; Richardson, Charles C.
  • Powder Diffraction, Vol. 26, Issue 2
  • DOI: 10.1154/1.3583156