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Title: Synthetic Biology for Therapeutic Applications

Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a number of biomedical challenges, such as emerging bacterial antibiotic resistance and cancer therapy. This review discusses some synthetic biology approaches and applications that were recently used in disease mechanism investigation and disease modeling, drug discovery and production, as well as vaccine development and treatment of infectious diseases, cancer, and metabolic disorders.
Authors:
 [1] ;  [2] ;  [3]
  1. Univ. of Illinois, Urbana, IL (United States). Dept. of Biochemistry
  2. Univ. of Illinois, Urbana, IL (United States). Dept. of Chemical and Biomolecular Engineering
  3. Univ. of Illinois, Urbana, IL (United States). Dept. of Biochemistry. Dept. of Chemical and Biomolecular Engineering. Dept. of Bioengineering. Dept. of Chemistry. Center for Biophysics and Computational Biology. Inst. for Genomic Biology
Publication Date:
Grant/Contract Number:
SC0008743; GM077596
Type:
Published Article
Journal Name:
Molecular Pharmaceutics
Additional Journal Information:
Journal Volume: 12; Journal Issue: 2; Journal ID: ISSN 1543-8384
Publisher:
American Chemical Society (ACS)
Research Org:
Univ. of Illinois at Urbana-Champaign, IL (United States)
Sponsoring Org:
USDOE Office of Science (SC), Biological and Environmental Research (BER) (SC-23); National Inst. of Health (NIH) (United States); Defense Advanced Research Projects Agency (DARPA) (United States)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 60 APPLIED LIFE SCIENCES; cancer treatment; disease mechanism; drug discovery; infectious diseases; metabolic disorders; synthetic biology; therapeutic treatment; vaccine development
OSTI Identifier:
1158718
Alternate Identifier(s):
OSTI ID: 1455064

Abil, Zhanar, Xiong, Xiong, and Zhao, Huimin. Synthetic Biology for Therapeutic Applications. United States: N. p., Web. doi:10.1021/mp500392q.
Abil, Zhanar, Xiong, Xiong, & Zhao, Huimin. Synthetic Biology for Therapeutic Applications. United States. doi:10.1021/mp500392q.
Abil, Zhanar, Xiong, Xiong, and Zhao, Huimin. 2014. "Synthetic Biology for Therapeutic Applications". United States. doi:10.1021/mp500392q.
@article{osti_1158718,
title = {Synthetic Biology for Therapeutic Applications},
author = {Abil, Zhanar and Xiong, Xiong and Zhao, Huimin},
abstractNote = {Synthetic biology is a relatively new field with the key aim of designing and constructing biological systems with novel functionalities. Today, synthetic biology devices are making their first steps in contributing new solutions to a number of biomedical challenges, such as emerging bacterial antibiotic resistance and cancer therapy. This review discusses some synthetic biology approaches and applications that were recently used in disease mechanism investigation and disease modeling, drug discovery and production, as well as vaccine development and treatment of infectious diseases, cancer, and metabolic disorders.},
doi = {10.1021/mp500392q},
journal = {Molecular Pharmaceutics},
number = 2,
volume = 12,
place = {United States},
year = {2014},
month = {8}
}