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Title: Structural Basis for Rational Design of Inhibitors Targeting Trypanosoma cruzi Sterol 14α-Demethylase: Two Regions of the Enzyme Molecule Potentiate Its Inhibition

Authors:
 [1] ;  [1] ;  [2] ;  [2] ;  [3] ;  [4] ;  [4] ;  [1] ;  [4] ;  [2] ;  [5]
  1. Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States
  2. Department of Microbiology and Immunology, Meharry Medical College, Nashville, Tennessee 37208, United States
  3. Synchrotron Research Center, Life Science Collaborative Access Team, Northwestern University, Argonne, Illinois 60439, United States
  4. “Istituto Pasteur-Fondazione Cenci Bolognetti”, Department of “Chimica e Tecnologie del Farmaco”, Sapienza University of Rome, Rome, 00185, Italy
  5. Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232, United States, Center for Structural Biology, Vanderbilt University, Nashville, Tennessee 37232, United States
Publication Date:
Type:
Published Article
Journal Name:
Journal of Medicinal Chemistry
Additional Journal Information:
Journal Volume: 57; Journal Issue: 15; Related Information: CHORUS Timestamp: 2017-11-09 11:32:39; Journal ID: ISSN 0022-2623
Publisher:
American Chemical Society
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
OSTI Identifier:
1158716