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Title: Measurement of Swine H1N1 Hemagglutinin Peptide binding with Piezoresistive Microcantilever Arrays

Abstract

The effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We also demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief.

Authors:
 [1];  [2];  [3];  [4]
  1. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
  2. David Grant USAF Medical Center, CA (United States)
  3. Univ. of Alberta, Edmonton, AB (Canada)
  4. Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States)
Publication Date:
Research Org.:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1133550
Grant/Contract Number:  
AC05-00OR22725
Resource Type:
Accepted Manuscript
Journal Name:
AIP Advances
Additional Journal Information:
Journal Volume: 4; Journal Issue: 3; Journal ID: ISSN 2158-3226
Publisher:
American Institute of Physics (AIP)
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Bajwa, Navdeep K, Maldonado, Carlos J., Thundat, Thomas George, and Passian, Ali. Measurement of Swine H1N1 Hemagglutinin Peptide binding with Piezoresistive Microcantilever Arrays. United States: N. p., 2014. Web. doi:10.1063/1.4869636.
Bajwa, Navdeep K, Maldonado, Carlos J., Thundat, Thomas George, & Passian, Ali. Measurement of Swine H1N1 Hemagglutinin Peptide binding with Piezoresistive Microcantilever Arrays. United States. doi:10.1063/1.4869636.
Bajwa, Navdeep K, Maldonado, Carlos J., Thundat, Thomas George, and Passian, Ali. Mon . "Measurement of Swine H1N1 Hemagglutinin Peptide binding with Piezoresistive Microcantilever Arrays". United States. doi:10.1063/1.4869636. https://www.osti.gov/servlets/purl/1133550.
@article{osti_1133550,
title = {Measurement of Swine H1N1 Hemagglutinin Peptide binding with Piezoresistive Microcantilever Arrays},
author = {Bajwa, Navdeep K and Maldonado, Carlos J. and Thundat, Thomas George and Passian, Ali},
abstractNote = {The effective detection of Swine H1N1 Hemagglutinin peptide is crucial as it could be used as a positive control to screen for highly infectious flu strains such as Swine-Origin Influenza A (H1N1). Piezoresistive microcantilever arrays present a pathway towards highly sensitive and label-free detection of biomolecules by transducing the antigen-antibody binding into change in resistivity via induced surface stress variation. We also demonstrate a mechanical transduction of Swine H1N1 Hemagglutinin peptide binding and suggest the employed technique may offer a potential platform for detection of the H1N1 virus, which could be clinically used to diagnose and provide subsequent relief.},
doi = {10.1063/1.4869636},
journal = {AIP Advances},
number = 3,
volume = 4,
place = {United States},
year = {2014},
month = {3}
}

Journal Article:
Free Publicly Available Full Text
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Cited by: 4 works
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Works referenced in this record:

Nanomechanical biosensors: a new sensing tool
journal, March 2006

  • Carrascosa, L. G.; Moreno, M.; Álvarez, M.
  • TrAC Trends in Analytical Chemistry, Vol. 25, Issue 3, p. 196-206
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