DOE PAGES title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Regulation and Function of Adult Neurogenesis. From Genes to Cognition

Abstract

Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness and potential impact on cognition but also to its localized vertical integration of different scales of neuroscience, ranging from molecular and cellular biology to behavior. Our review summarizes the recent research regarding the process of adult neurogenesis from these different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit. Arising from a local neural stem cell population, new neurons progress through several stages of maturation, ultimately integrating into the adult dentate gyrus network. Furthermore, the increased appreciation of the full neurogenesis process, from genes and cells to behavior and cognition, makes neurogenesis both a unique case study for how scales in neuroscience can link together and suggests neurogenesis as a potential target for therapeutic intervention for a number of disorders.

Authors:
 [1];  [1];  [1];  [1];  [1];  [1]
  1. Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Salt Inst. for Biological Studies, La Jolla, CA (United States)
Publication Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE National Nuclear Security Administration (NNSA)
OSTI Identifier:
1114606
Report Number(s):
SAND-2013-8756J
Journal ID: ISSN 0031-9333; 476985
Grant/Contract Number:  
AC04-94AL85000
Resource Type:
Accepted Manuscript
Journal Name:
Physiological Reviews
Additional Journal Information:
Journal Volume: 94; Journal Issue: 4; Journal ID: ISSN 0031-9333
Publisher:
American Physiological Society
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., and Gage, F. H. Regulation and Function of Adult Neurogenesis. From Genes to Cognition. United States: N. p., 2014. Web. doi:10.1152/physrev.00004.2014.
Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., & Gage, F. H. Regulation and Function of Adult Neurogenesis. From Genes to Cognition. United States. https://doi.org/10.1152/physrev.00004.2014
Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., and Gage, F. H. Wed . "Regulation and Function of Adult Neurogenesis. From Genes to Cognition". United States. https://doi.org/10.1152/physrev.00004.2014. https://www.osti.gov/servlets/purl/1114606.
@article{osti_1114606,
title = {Regulation and Function of Adult Neurogenesis. From Genes to Cognition},
author = {Aimone, J. B. and Li, Y. and Lee, S. W. and Clemenson, G. D. and Deng, W. and Gage, F. H.},
abstractNote = {Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness and potential impact on cognition but also to its localized vertical integration of different scales of neuroscience, ranging from molecular and cellular biology to behavior. Our review summarizes the recent research regarding the process of adult neurogenesis from these different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit. Arising from a local neural stem cell population, new neurons progress through several stages of maturation, ultimately integrating into the adult dentate gyrus network. Furthermore, the increased appreciation of the full neurogenesis process, from genes and cells to behavior and cognition, makes neurogenesis both a unique case study for how scales in neuroscience can link together and suggests neurogenesis as a potential target for therapeutic intervention for a number of disorders.},
doi = {10.1152/physrev.00004.2014},
journal = {Physiological Reviews},
number = 4,
volume = 94,
place = {United States},
year = {Wed Oct 01 00:00:00 EDT 2014},
month = {Wed Oct 01 00:00:00 EDT 2014}
}

Journal Article:
Free Publicly Available Full Text
Publisher's Version of Record

Citation Metrics:
Cited by: 414 works
Citation information provided by
Web of Science

Save / Share:

Works referenced in this record:

Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
journal, April 2004

  • Schmidt-Hieber, Christoph; Jonas, Peter; Bischofberger, Josef
  • Nature, Vol. 429, Issue 6988
  • DOI: 10.1038/nature02553

Optogenetic stimulation of a hippocampal engram activates fear memory recall
journal, March 2012

  • Liu, Xu; Ramirez, Steve; Pang, Petti T.
  • Nature, Vol. 484, Issue 7394
  • DOI: 10.1038/nature11028

Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo
journal, August 2002

  • Jin, K.; Zhu, Y.; Sun, Y.
  • Proceedings of the National Academy of Sciences, Vol. 99, Issue 18
  • DOI: 10.1073/pnas.182296499

The Development and Application of Optogenetics
journal, July 2011


Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus
journal, January 2007


Reversible modulations of neuronal plasticity by VEGF
journal, March 2011

  • Licht, T.; Goshen, I.; Avital, A.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 12
  • DOI: 10.1073/pnas.1007640108

Epigenetic choreographers of neurogenesis in the adult mammalian brain
journal, October 2010

  • Ma, Dengke K.; Marchetto, Maria Carolina; Guo, Junjie U.
  • Nature Neuroscience, Vol. 13, Issue 11
  • DOI: 10.1038/nn.2672

Dopaminergic Modulation of Cortical Inputs during Maturation of Adult-Born Dentate Granule Cells
journal, March 2011


Suppression of adult neurogenesis impairs population coding of similar contexts in hippocampal CA3 region
journal, January 2012

  • Niibori, Yosuke; Yu, Tzong-Shiue; Epp, Jonathan R.
  • Nature Communications, Vol. 3, Issue 1
  • DOI: 10.1038/ncomms2261

Brain-Derived Neurotrophic Factor Is Associated with Age-Related Decline in Hippocampal Volume
journal, April 2010


Development of GABAergic inputs controls the contribution of maturing neurons to the adult hippocampal network
journal, February 2012

  • Li, Y.; Aimone, J. B.; Xu, X.
  • Proceedings of the National Academy of Sciences, Vol. 109, Issue 11
  • DOI: 10.1073/pnas.1120754109

Vascular niche for adult hippocampal neurogenesis
journal, January 2000


The fate of neural progenitor cells expressing astrocytic and radial glial markers in the postnatal rat dentate gyrus
journal, October 2005


Distribution of Brain-Derived Neurotrophic Factor in Rats and Its Changes with Development in the Brain
journal, July 1997


A Distinctive layering pattern of mouse dentate granule cells is generated by developmental and adult neurogenesis
journal, September 2010

  • Mathews, Emily A.; Morgenstern, Nicolás A.; Piatti, Verónica C.
  • The Journal of Comparative Neurology, Vol. 518, Issue 22
  • DOI: 10.1002/cne.22489

Impact of diet on adult hippocampal neurogenesis
journal, August 2009


The Interesting Interplay Between Interneurons and Adult Hippocampal Neurogenesis
journal, September 2011


Synapse formation on neurons born in the adult hippocampus
journal, May 2007

  • Toni, Nicolas; Teng, E. Matthew; Bushong, Eric A.
  • Nature Neuroscience, Vol. 10, Issue 6
  • DOI: 10.1038/nn1908

Creating a False Memory in the Hippocampus
journal, July 2013


Cardiovascular responses to voluntary and treadmill exercise in rats
journal, September 1993


Paracrine Intercellular Communication by a Ca2+- and SNARE-Independent Release of GABA and Glutamate Prior to Synapse Formation
journal, December 2002


Astrocytes Negatively Regulate Neurogenesis Through the Jagged1-Mediated Notch Pathway: Astrocytes Regulate Neurogenesis
journal, September 2012

  • Wilhelmsson, Ulrika; Faiz, Maryam; de Pablo, Yolanda
  • STEM CELLS, Vol. 30, Issue 10
  • DOI: 10.1002/stem.1196

TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
journal, August 2008


Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?
journal, October 2009


Immune Influence on Adult Neural Stem Cell Regulation and Function
journal, October 2009


GABAergic Excitation Promotes Neuronal Differentiation in Adult Hippocampal Progenitor Cells
journal, September 2005


Additive neurogenesis as a strategy for avoiding interference in a sparsely-coding dentate gyrus
journal, January 2009

  • Appleby, Peter A.; Wiskott, Laurenz
  • Network: Computation in Neural Systems, Vol. 20, Issue 3
  • DOI: 10.1080/09548980902993156

Young Dentate Granule Cells Mediate Pattern Separation, whereas Old Granule Cells Facilitate Pattern Completion
journal, March 2012


Hippocampal granule cells opt for early retirement
journal, August 2010

  • Alme, C. B.; Buzzetti, R. A.; Marrone, D. F.
  • Hippocampus, Vol. 20, Issue 10
  • DOI: 10.1002/hipo.20810

Differential effects of learning on neurogenesis: learning increases or decreases the number of newly born cells depending on their birth date
journal, November 2003

  • Döbrössy, M. D.; Drapeau, E.; Aurousseau, C.
  • Molecular Psychiatry, Vol. 8, Issue 12
  • DOI: 10.1038/sj.mp.4001419

Exercise-Induced Changes in Local Cerebral Glucose Utilization in the Rat
journal, July 1996


Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
journal, February 2004

  • Sanai, Nader; Tramontin, Anthony D.; Quiñones-Hinojosa, Alfredo
  • Nature, Vol. 427, Issue 6976
  • DOI: 10.1038/nature02301

The Alpha2-Adrenoceptor Antagonist Dexefaroxan Enhances Hippocampal Neurogenesis by Increasing the Survival and Differentiation of New Granule Cells
journal, November 2005

  • Rizk, Pamela; Salazar, Julio; Raisman-Vozari, Rita
  • Neuropsychopharmacology, Vol. 31, Issue 6
  • DOI: 10.1038/sj.npp.1300954

Comparative anatomy of the hippocampal dentate gyrus in adult and developing rodents, non-human primates and humans
book, January 2007


A possible negative influence of depression on the ability to overcome memory interference
journal, November 2013


Adult hippocampal neurogenesis buffers stress responses and depressive behaviour
journal, August 2011

  • Snyder, Jason S.; Soumier, Amélie; Brewer, Michelle
  • Nature, Vol. 476, Issue 7361
  • DOI: 10.1038/nature10287

Learning-Induced Survival of New Neurons Depends on the Cognitive Status of Aged Rats
journal, May 2007


Expression cloning of a diphtheria toxin receptor: Identity with a heparin-binding EGF-like growth factor precursor
journal, June 1992


A task to assess behavioral pattern separation (BPS) in humans: Data from healthy aging and mild cognitive impairment
journal, October 2013


Is there a support vector machine hiding in the dentate gyrus?
journal, June 2003


Learning enhances adult neurogenesis in the hippocampal formation
journal, March 1999

  • Gould, Elizabeth; Beylin, Anna; Tanapat, Patima
  • Nature Neuroscience, Vol. 2, Issue 3
  • DOI: 10.1038/6365

Polyphenols: food sources and bioavailability
journal, May 2004

  • Manach, Claudine; Scalbert, Augustin; Morand, Christine
  • The American Journal of Clinical Nutrition, Vol. 79, Issue 5
  • DOI: 10.1093/ajcn/79.5.727

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
journal, March 1999

  • van Praag, Henriette; Kempermann, Gerd; Gage, Fred H.
  • Nature Neuroscience, Vol. 2, Issue 3
  • DOI: 10.1038/6368

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
journal, March 2007

  • Armbruster, B. N.; Li, X.; Pausch, M. H.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 12
  • DOI: 10.1073/pnas.0700293104

Spatial Learning Depends on Both the Addition and Removal of New Hippocampal Neurons
journal, August 2007


Adult SVZ Stem Cells Lie in a Vascular Niche: A Quantitative Analysis of Niche Cell-Cell Interactions
journal, September 2008


Neuronal domains in developing neocortex
journal, July 1992


Double dissociation of function within the hippocampus: Spatial memory and hyponeophagia.
journal, January 2002


Monosynaptic inputs to new neurons in the dentate gyrus
journal, January 2012

  • Vivar, Carmen; Potter, Michelle C.; Choi, Jiwon
  • Nature Communications, Vol. 3, Issue 1
  • DOI: 10.1038/ncomms2101

Temporal associations for spatial events: The role of the dentate gyrus
journal, November 2013

  • Morris, Andrea M.; Curtis, Brian J.; Churchwell, John C.
  • Behavioural Brain Research, Vol. 256
  • DOI: 10.1016/j.bbr.2013.08.021

Neurogenesis in the Hypothalamus of Adult Mice: Potential Role in Energy Balance
journal, October 2005


Modulation of Hippocampal Plasticity and Cognitive Behavior by Short-term Blueberry Supplementation in Aged Rats
journal, October 2004

  • Casadesus, Gemma; Shukitt-Hale, Barbara; Stellwagen, Heather M.
  • Nutritional Neuroscience, Vol. 7, Issue 5-6
  • DOI: 10.1080/10284150400020482

Inferences, questions and possibilities in Toll-like receptor signalling
journal, July 2004


Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function
journal, January 2012


5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus
journal, November 2002


Hippocampal conjunctive encoding, storage, and recall: Avoiding a trade-off
journal, December 1994


Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension
journal, February 2007


Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice
journal, September 2005


Secreted Frizzled-Related Protein 3 Regulates Activity-Dependent Adult Hippocampal Neurogenesis
journal, February 2013


Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis
journal, August 2009

  • Kuwabara, Tomoko; Hsieh, Jenny; Muotri, Alysson
  • Nature Neuroscience, Vol. 12, Issue 9
  • DOI: 10.1038/nn.2360

Unique Processing During a Period of High Excitation/Inhibition Balance in Adult-Born Neurons
journal, January 2012

  • Marín-Burgin, Antonia; Mongiat, Lucas A.; Pardi, M. Belén
  • Science, Vol. 335, Issue 6073
  • DOI: 10.1126/science.1214956

Astrocytes regulate adult hippocampal neurogenesis through ephrin-B signaling
journal, September 2012

  • Ashton, Randolph S.; Conway, Anthony; Pangarkar, Chinmay
  • Nature Neuroscience, Vol. 15, Issue 10
  • DOI: 10.1038/nn.3212

Hippocampal neurogenesis and forgetting
journal, September 2013

  • Frankland, Paul W.; Köhler, Stefan; Josselyn, Sheena A.
  • Trends in Neurosciences, Vol. 36, Issue 9
  • DOI: 10.1016/j.tins.2013.05.002

Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior
journal, August 2012

  • Fitzsimons, C. P.; van Hooijdonk, L. W. A.; Schouten, M.
  • Molecular Psychiatry, Vol. 18, Issue 9
  • DOI: 10.1038/mp.2012.123

Effects of Concord grape juice on cognitive and motor deficits in aging
journal, March 2006


Fluorescence measurement and photochemical manipulation of cytosolic free calcium
journal, January 1988


Enhanced Learning and Memory and Altered GABAergic Synaptic Transmission in Mice Lacking the α5 Subunit of the GABA A Receptor
journal, July 2002


Age-related memory deficits linked to circuit-specific disruptions in the hippocampus
journal, May 2011

  • Yassa, M. A.; Mattfeld, A. T.; Stark, S. M.
  • Proceedings of the National Academy of Sciences, Vol. 108, Issue 21
  • DOI: 10.1073/pnas.1101567108

Alterations in the Thickness of Motor Cortical Subregions After Motor-Skill Learning and Exercise
journal, January 2002


Functional implications of decreases in neurogenesis following chronic mild stress in mice
journal, December 2007


Are New Neurons Formed in the Brains of Adult Mammals?
journal, March 1962


Neurogenic niche modulation by activated microglia: transforming growth factor β increases neurogenesis in the adult dentate gyrus
journal, January 2006


Neurogenesis in the adult is involved in the formation of trace memories
journal, March 2001

  • Shors, Tracey J.; Miesegaes, George; Beylin, Anna
  • Nature, Vol. 410, Issue 6826
  • DOI: 10.1038/35066584

Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels
journal, August 2008


A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation
journal, July 2009


Direct Stimulation of Adult Neural Stem Cells In Vitro and Neurogenesis In Vivo by Vascular Endothelial Growth Factor
journal, July 2004


A high signal-to-noise Ca2+ probe composed of a single green fluorescent protein
journal, February 2001

  • Nakai, Junichi; Ohkura, Masamichi; Imoto, Keiji
  • Nature Biotechnology, Vol. 19, Issue 2
  • DOI: 10.1038/84397

Fractalkine and CX3CR1 regulate hippocampal neurogenesis in adult and aged rats
journal, November 2011


Enhanced habit-based learning and decreased neurogenesis in the adult hippocampus in a murine model of chronic social stress
journal, June 2010


Diphtheria toxin: mode of action and structure.
journal, January 1975


Pattern Separation in the Human Hippocampal CA3 and Dentate Gyrus
journal, March 2008


Silencing preBötzinger Complex somatostatin-expressing neurons induces persistent apnea in awake rat
journal, April 2008

  • Tan, Wenbin; Janczewski, Wiktor A.; Yang, Paul
  • Nature Neuroscience, Vol. 11, Issue 5
  • DOI: 10.1038/nn.2104

A putative role for neurogenesis in neurocomputational terms: Inferences from a hippocampal model
journal, August 2009


A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain
journal, May 2007


Single granule cells reliably discharge targets in the hippocampal CA3 network in vivo
journal, July 2002

  • Henze, Darrell A.; Wittner, Lucia; Buzsáki, György
  • Nature Neuroscience, Vol. 5, Issue 8
  • DOI: 10.1038/nn887

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision
journal, July 2012

  • Song, Juan; Zhong, Chun; Bonaguidi, Michael A.
  • Nature, Vol. 489, Issue 7414
  • DOI: 10.1038/nature11306

Preferential incorporation of adult-generated granule cells into spatial memory networks in the dentate gyrus
journal, February 2007

  • Kee, Nohjin; Teixeira, Cátia M.; Wang, Afra H.
  • Nature Neuroscience, Vol. 10, Issue 3
  • DOI: 10.1038/nn1847

The neurogenesis hypothesis of affective and anxiety disorders: Are we mistaking the scaffolding for the building?
journal, January 2012


Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?
journal, January 2010


Neurogenesis in adult primate neocortex: an evaluation of the evidence
journal, January 2002

  • Rakic, Pasko
  • Nature Reviews Neuroscience, Vol. 3, Issue 1
  • DOI: 10.1038/nrn700

Adrenal hormones suppress cell division in the adult rat dentate gyrus
journal, September 1992


Functional neurogenesis in the adult hippocampus
journal, February 2002

  • van Praag, Henriette; Schinder, Alejandro F.; Christie, Brian R.
  • Nature, Vol. 415, Issue 6875
  • DOI: 10.1038/4151030a

Hippocampal Network Hyperactivity After Selective Reduction of Tonic Inhibition in GABA A Receptor α5 Subunit–Deficient Mice
journal, May 2006


In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics
journal, June 2011


An autoradiographic study of the organization of the efferet connections of the hippocampal formation in the rat
journal, March 1977

  • Swanson, L. W.; Cowan, W. M.
  • The Journal of Comparative Neurology, Vol. 172, Issue 1
  • DOI: 10.1002/cne.901720104

Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor.
journal, April 1995

  • Naya, F. J.; Stellrecht, C. M.; Tsai, M. J.
  • Genes & Development, Vol. 9, Issue 8
  • DOI: 10.1101/gad.9.8.1009

Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors
journal, July 2009


The Age of Olfactory Bulb Neurons in Humans
journal, May 2012


Posttraining Ablation of Adult-Generated Neurons Degrades Previously Acquired Memories
journal, October 2011


NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration
journal, November 2010


A Cre-inducible diphtheria toxin receptor mediates cell lineage ablation after toxin administration
journal, May 2005

  • Buch, Thorsten; Heppner, Frank L.; Tertilt, Christine
  • Nature Methods, Vol. 2, Issue 6
  • DOI: 10.1038/nmeth762

Inflammatory Blockade Restores Adult Hippocampal Neurogenesis
journal, December 2003


The Adult Rat Hippocampus Contains Primordial Neural Stem Cells
journal, January 1997

  • Palmer, Theo D.; Takahashi, Jun; Gage, Fred H.
  • Molecular and Cellular Neuroscience, Vol. 8, Issue 6
  • DOI: 10.1006/mcne.1996.0595

Use of fluorocitrate and fluoroacetate in the study of brain metabolism
journal, September 1997


Directional guidance of neuronal migration in the olfactory system by the protein Slit
journal, July 1999

  • Wu, Wei; Wong, Kit; Chen, Jin-hui
  • Nature, Vol. 400, Issue 6742
  • DOI: 10.1038/22477

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
journal, March 2010

  • Deng, Wei; Aimone, James B.; Gage, Fred H.
  • Nature Reviews Neuroscience, Vol. 11, Issue 5
  • DOI: 10.1038/nrn2822

The Role of Additive Neurogenesis and Synaptic Plasticity in a Hippocampal Memory Model with Grid-Cell Like Input
journal, January 2011


A computational principle for hippocampal learning and neurogenesis
journal, January 2005


Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche
journal, October 2011

  • Markwardt, Sean J.; Dieni, Cristina V.; Wadiche, Jacques I.
  • Nature Neuroscience, Vol. 14, Issue 11
  • DOI: 10.1038/nn.2935

In Vivo Simultaneous Tracing and Ca2+ Imaging of Local Neuronal Circuits
journal, March 2007


Mechanisms and Functional Implications of Adult Neurogenesis
journal, February 2008


Cell formation in the human hippocampal formation from mid-gestation to the late postnatal period
journal, August 2001


Orchestrating transcriptional control of adult neurogenesis
journal, May 2012


A hypothesis for temporal coding of young and mature granule cells
journal, January 2013


GABA Regulates Excitatory Synapse Formation in the Neocortex via NMDA Receptor Activation
journal, May 2008


MSK1 Regulates Homeostatic and Experience-Dependent Synaptic Plasticity
journal, September 2012


Signaling mechanisms regulating adult neural stem cells and neurogenesis
journal, February 2013

  • Faigle, Roland; Song, Hongjun
  • Biochimica et Biophysica Acta (BBA) - General Subjects, Vol. 1830, Issue 2
  • DOI: 10.1016/j.bbagen.2012.09.002

Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone
journal, November 2000

  • Conover, Joanne C.; Doetsch, Fiona; Garcia-Verdugo, Jose-Manuel
  • Nature Neuroscience, Vol. 3, Issue 11
  • DOI: 10.1038/80606

Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus
journal, December 2000


Endogenous Wnt Signaling Maintains Neural Progenitor Cell Potency
journal, October 2009

  • Wexler, Eric M.; Paucer, Andres; Kornblum, HArley I.
  • Stem Cells, Vol. 27, Issue 10, p. 2636-2636
  • DOI: 10.1002/stem.239

Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
journal, July 2002

  • Kempermann, Gerd; Gast, Daniela; Gage, Fred H.
  • Annals of Neurology, Vol. 52, Issue 2
  • DOI: 10.1002/ana.10262

Temporally Graded Retrograde Amnesia of Contextual Fear after Hippocampal Damage in Rats: Within-Subjects Examination
journal, February 1999


Serotonin Is Required for Exercise-Induced Adult Hippocampal Neurogenesis
journal, May 2013


Regulation of adult neurogenesis in the hippocampus by stress, acetylcholine and dopamine
journal, January 2011

  • Srikumar, Bn; Veena, J.; Shankaranarayana Rao, Bs
  • Journal of Natural Science, Biology and Medicine, Vol. 2, Issue 1
  • DOI: 10.4103/0976-9668.82312

Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons
journal, April 2010

  • Tronel, Sophie; Fabre, Annabelle; Charrier, Vanessa
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 17
  • DOI: 10.1073/pnas.0914613107

A model of hippocampal neurogenesis in memory and mood disorders
journal, February 2007


Similar GABAergic inputs in dentate granule cells born during embryonic and adult neurogenesis: GABAergic inhibition in embryo- and adult-born neurons
journal, May 2007


Input-Specific GABAergic Signaling to Newborn Neurons in Adult Dentate Gyrus
journal, December 2009


Extensive training in a maze task reduces neurogenesis in the adult rat dentate gyrus probably as a result of stress
journal, April 2007


Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain
journal, October 2009


GABA stimulates chemotaxis and chemokinesis of embryonic cortical neurons via calcium-dependent mechanisms
journal, March 1996


GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis
journal, December 1995


Genetic dissection of an amygdala microcircuit that gates conditioned fear
journal, November 2010

  • Haubensak, Wulf; Kunwar, Prabhat S.; Cai, Haijiang
  • Nature, Vol. 468, Issue 7321
  • DOI: 10.1038/nature09553

Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways
journal, January 2006

  • Olson, Andrea K.; Eadie, Brennan D.; Ernst, Carl
  • Hippocampus, Vol. 16, Issue 3
  • DOI: 10.1002/hipo.20157

What's new is older
journal, March 2013


Seven principles in the regulation of adult neurogenesis: Regulation of adult neurogenesis
journal, March 2011


Why Are Some Neurons Replaced in Adult Brain?
journal, February 2002


A new touchscreen test of pattern separation: effect of hippocampal lesions
journal, January 2009


Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis
journal, October 2010


A functional hypothesis for adult hippocampal neurogenesis: Avoidance of catastrophic interference in the dentate gyrus
journal, January 2006

  • Wiskott, Laurenz; Rasch, Malte J.; Kempermann, Gerd
  • Hippocampus, Vol. 16, Issue 3
  • DOI: 10.1002/hipo.20167

Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice
journal, March 2004


Neurogenesis in a High Resolution Dentate Gyrus Model
book, January 2013

  • Vineyard, Craig M.; Aimone, James B.; Emmanuel, Glory R.
  • Biologically Inspired Cognitive Architectures 2012
  • DOI: 10.1007/978-3-642-34274-5_65

Astrocyte-derived ATP modulates depressive-like behaviors
journal, May 2013

  • Cao, Xiong; Li, Liang-Ping; Wang, Qian
  • Nature Medicine, Vol. 19, Issue 6
  • DOI: 10.1038/nm.3162

Potential role for adult neurogenesis in the encoding of time in new memories
journal, May 2006

  • Aimone, James B.; Wiles, Janet; Gage, Fred H.
  • Nature Neuroscience, Vol. 9, Issue 6
  • DOI: 10.1038/nn1707

Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus
journal, July 1994


Microglia-associated granule cell death in the normal adult dentate gyrus
journal, November 2009

  • Ribak, Charles E.; Shapiro, Lee A.; Perez, Zachary D.
  • Brain Structure and Function, Vol. 214, Issue 1
  • DOI: 10.1007/s00429-009-0231-7

Microglial Cells in Culture Express a Prominent Glutathione System for the Defense against Reactive Oxygen Species
journal, January 2000

  • Hirrlinger, Johannes; Gutterer, Jan Mirko; Kussmaul, Lothar
  • Developmental Neuroscience, Vol. 22, Issue 5-6
  • DOI: 10.1159/000017464

Changing Properties of GABA A Receptor–Mediated Signaling During Early Neocortical Development
journal, August 1999

  • Owens, David F.; Liu, Xiaolin; Kriegstein, Arnold R.
  • Journal of Neurophysiology, Vol. 82, Issue 2
  • DOI: 10.1152/jn.1999.82.2.570

Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus
journal, January 2001

  • Cameron, Heather A.; Mckay, Ronald D. G.
  • The Journal of Comparative Neurology, Vol. 435, Issue 4
  • DOI: 10.1002/cne.1040

Molecular Structure and Physiological Function of Chloride Channels
journal, April 2002


Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus
journal, September 2004

  • Schmidt-Hieber, Christoph; Jonas, Peter; Bischofberger, Josef
  • e-Neuroforum, Vol. 10, Issue 3
  • DOI: 10.1515/nf-2004-0305

Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory
journal, November 2009


A genetically encoded calcium indicator for chronic in vivo two-photon imaging
journal, August 2008

  • Mank, Marco; Santos, Alexandre Ferrão; Direnberger, Stephan
  • Nature Methods, Vol. 5, Issue 9, p. 805-811
  • DOI: 10.1038/nmeth.1243

Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene
journal, July 1987


A unifying hypothesis on mammalian neural stem cell properties in the adult hippocampus
journal, October 2012

  • Bonaguidi, Michael A.; Song, Juan; Ming, Guo-li
  • Current Opinion in Neurobiology, Vol. 22, Issue 5
  • DOI: 10.1016/j.conb.2012.03.013

Molecular layer perforant path-associated cells contribute to feed-forward inhibition in the adult dentate gyrus
journal, May 2013

  • Li, Y.; Stam, F. J.; Aimone, J. B.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 22
  • DOI: 10.1073/pnas.1306912110

Hippocampal Neurogenesis is not Required for Behavioral Effects of Environmental Enrichment
journal, August 2006


Control of microglial neurotoxicity by the fractalkine receptor
journal, June 2006

  • Cardona, Astrid E.; Pioro, Erik P.; Sasse, Margaret E.
  • Nature Neuroscience, Vol. 9, Issue 7
  • DOI: 10.1038/nn1715

The effects of stress and stress hormones on human cognition: Implications for the field of brain and cognition
journal, December 2007


Adult Spinal Cord Stem Cells Generate Neurons after Transplantation in the Adult Dentate Gyrus
journal, December 2000


Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS
journal, October 1999


Diphtheria toxin receptor–mediated conditional and targeted cell ablation in transgenic mice
journal, August 2001

  • Saito, Michiko; Iwawaki, Takao; Taya, Choji
  • Nature Biotechnology, Vol. 19, Issue 8
  • DOI: 10.1038/90795

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation
journal, March 1996


A behavioral analysis of dentate gyrus function
book, January 2007

  • Kesner, Raymond P.
  • The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications
  • DOI: 10.1016/S0079-6123(07)63030-1

NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus
journal, August 2006

  • Tashiro, Ayumu; Sandler, Vladislav M.; Toni, Nicolas
  • Nature, Vol. 442, Issue 7105
  • DOI: 10.1038/nature05028

Chronic Social Stress Inhibits Cell Proliferation in the Adult Medial Prefrontal Cortex: Hemispheric Asymmetry and Reversal by Fluoxetine Treatment
journal, December 2006

  • Czéh, Boldizsár; Müller-Keuker, Jeanine I. H.; Rygula, Rafal
  • Neuropsychopharmacology, Vol. 32, Issue 7
  • DOI: 10.1038/sj.npp.1301275

Synapse formation on adult-born hippocampal neurons: Adult neurogenesis and synaptogenesis
journal, March 2011


Paradoxical influence of hippocampal neurogenesis on working memory
journal, March 2007

  • Saxe, M. D.; Malleret, G.; Vronskaya, S.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 11
  • DOI: 10.1073/pnas.0611718104

Emergence of Individuality in Genetically Identical Mice
journal, May 2013


Plant-Derived Flavanol (-)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice
journal, May 2007


MSK activation and physiological roles
journal, January 2008

  • Arthur, J. Simon, C.
  • Frontiers in Bioscience, Vol. Volume, Issue 13
  • DOI: 10.2741/3122

Behavioral Effects of Chronic Fluoxetine in BALB/cJ Mice Do Not Require Adult Hippocampal Neurogenesis or the Serotonin 1A Receptor
journal, April 2007

  • Holick, Kerri A.; Lee, Daniel C.; Hen, René
  • Neuropsychopharmacology, Vol. 33, Issue 2
  • DOI: 10.1038/sj.npp.1301399

Computational Influence of Adult Neurogenesis on Memory Encoding
journal, January 2009


Regulation of Excitability by Extrasynaptic GABAA Receptors
book, January 2008

  • Walker, Matthew C.; Semyanov, Alexey
  • Inhibitory Regulation of Excitatory Neurotransmission
  • DOI: 10.1007/400_2007_030

Taurine Inhibits K + -Cl Cotransporter KCC2 to Regulate Embryonic Cl Homeostasis via With-no-lysine (WNK) Protein Kinase Signaling Pathway
journal, April 2012

  • Inoue, Koichi; Furukawa, Tomonori; Kumada, Tatsuro
  • Journal of Biological Chemistry, Vol. 287, Issue 25
  • DOI: 10.1074/jbc.M111.319418

Serotonergic control of the hippocampus via local inhibitory interneurons.
journal, November 1990

  • Freund, T. F.; Gulyas, A. I.; Acsady, L.
  • Proceedings of the National Academy of Sciences, Vol. 87, Issue 21
  • DOI: 10.1073/pnas.87.21.8501

In Vivo Fate Analysis Reveals the Multipotent and Self-Renewal Capacities of Sox2+ Neural Stem Cells in the Adult Hippocampus
journal, November 2007


Hippocampal neurogenesis is not required for behavioral effects of environmental enrichment
journal, April 2006

  • Meshi, Dar; Drew, Michael R.; Saxe, Michael
  • Nature Neuroscience, Vol. 9, Issue 6
  • DOI: 10.1038/nn1696

Neurogenesis in Adult Mammals: Some Progress and Problems
journal, February 2002


Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
journal, April 2005


Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient mice
journal, September 1997


Reliable Activation of Immature Neurons in the Adult Hippocampus
journal, April 2009


Genetic Regulation of Behavioral and Neuronal Responses to Fluoxetine
journal, July 2007

  • Miller, Brooke H.; Schultz, Laura E.; Gulati, Anisha
  • Neuropsychopharmacology, Vol. 33, Issue 6
  • DOI: 10.1038/sj.npp.1301497

Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus
journal, January 2008


Flavonoid Intake and Cognitive Decline over a 10-Year Period
journal, March 2007

  • Letenneur, L.; Proust-Lima, C.; Le Gouge, A.
  • American Journal of Epidemiology, Vol. 165, Issue 12
  • DOI: 10.1093/aje/kwm036

Computational constraints suggest the need for two distinct input systems to the hippocampal CA3 network
journal, April 1992


Exercise increases metabolic capacity in the motor cortex and striatum, but not in the hippocampus
journal, February 2001


Functional differentiation in the hippocampus
journal, January 1998


Chronically Increased Transforming Growth Factor-β1 Strongly Inhibits Hippocampal Neurogenesis in Aged Mice
journal, July 2006

  • Buckwalter, Marion S.; Yamane, Makiko; Coleman, Bronwen S.
  • The American Journal of Pathology, Vol. 169, Issue 1
  • DOI: 10.2353/ajpath.2006.051272

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand
text, January 2007

  • M. H., Pausch,; S., Herlitze,; B. L., Roth,
  • National Academy of Sciences
  • DOI: 10.17615/72c9-cp16

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
journal, October 1992

  • Schiavo, Giampietro G.; Benfenati, Fabio; Poulain, Bernard
  • Nature, Vol. 359, Issue 6398
  • DOI: 10.1038/359832a0

Differential Control of Learning and Anxiety along the Dorsoventral Axis of the Dentate Gyrus
journal, March 2013


Intracellular chloride concentration influences the GABAA receptor subunit composition
journal, January 2012

  • Succol, Francesca; Fiumelli, Hubert; Benfenati, Fabio
  • Nature Communications, Vol. 3, Issue 1
  • DOI: 10.1038/ncomms1744

A Genetic Method for Selective and Quickly Reversible Silencing of Mammalian Neurons
journal, July 2002


Gene-expression profile of the ageing brain in mice
journal, July 2000

  • Lee, Cheol-Koo; Weindruch, Richard; Prolla, Tomas A.
  • Nature Genetics, Vol. 25, Issue 3
  • DOI: 10.1038/77046

Neural stem and progenitor cells in nestin-GFP transgenic mice
journal, January 2004

  • Mignone, John L.; Kukekov, Valery; Chiang, Ann-Shyn
  • The Journal of Comparative Neurology, Vol. 469, Issue 3
  • DOI: 10.1002/cne.10964

Adult brain neurogenesis and psychiatry: a novel theory of depression
journal, May 2000

  • Jacobs, B. L.; van Praag, H.; Gage, F. H.
  • Molecular Psychiatry, Vol. 5, Issue 3
  • DOI: 10.1038/sj.mp.4000712

TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
journal, November 2008


Distinct Modes of Neuron Addition in Adult Mouse Neurogenesis
journal, October 2007


Neurogenesis may relate to some but not all types of hippocampal-dependent learning
journal, January 2002

  • Shors, Tracey J.; Townsend, David A.; Zhao, Mingrui
  • Hippocampus, Vol. 12, Issue 5
  • DOI: 10.1002/hipo.10103

Stress, stress hormones, and adult neurogenesis
journal, January 2012


Reversals of Age-Related Declines in Neuronal Signal Transduction, Cognitive, and Motor Behavioral Deficits with Blueberry, Spinach, or Strawberry Dietary Supplementation
journal, September 1999


Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors
journal, August 2005

  • Liu, Xiuxin; Wang, Qin; Haydar, Tarik F.
  • Nature Neuroscience, Vol. 8, Issue 9
  • DOI: 10.1038/nn1522

Spatially asymmetric reorganization of inhibition establishes a motion-sensitive circuit
journal, December 2010

  • Yonehara, Keisuke; Balint, Kamill; Noda, Masaharu
  • Nature, Vol. 469, Issue 7330
  • DOI: 10.1038/nature09711

Neural mechanisms of ageing and cognitive decline
journal, March 2010

  • Bishop, Nicholas A.; Lu, Tao; Yankner, Bruce A.
  • Nature, Vol. 464, Issue 7288
  • DOI: 10.1038/nature08983

Cortical representations of olfactory input by trans-synaptic tracing
journal, December 2010

  • Miyamichi, Kazunari; Amat, Fernando; Moussavi, Farshid
  • Nature, Vol. 472, Issue 7342
  • DOI: 10.1038/nature09714

Intermediate Progenitors in Adult Hippocampal Neurogenesis: Tbr2 Expression and Coordinate Regulation of Neuronal Output
journal, April 2008


New neurons in an aged brain
journal, February 2012

  • Lee, Star W.; Clemenson, Gregory D.; Gage, Fred H.
  • Behavioural Brain Research, Vol. 227, Issue 2
  • DOI: 10.1016/j.bbr.2011.10.009

Noradrenaline increases neural precursor cells derived from adult rat dentate gyrus through beta2 receptor
journal, January 2012

  • Masuda, Takahiro; Nakagawa, Shin; Boku, Shuken
  • Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 36, Issue 1
  • DOI: 10.1016/j.pnpbp.2011.08.019

BDNF and trkB mRNA expression in the hippocampal formation of aging rats
journal, March 1993


Prox1 expression patterns in the developing and adult murine brain
journal, January 2007

  • Lavado, Alfonso; Oliver, Guillermo
  • Developmental Dynamics, Vol. 236, Issue 2
  • DOI: 10.1002/dvdy.21024

Division-Coupled Astrocytic Differentiation and Age-Related Depletion of Neural Stem Cells in the Adult Hippocampus
journal, May 2011


Neurogenesis-Dependent and -Independent Effects of Fluoxetine in an Animal Model of Anxiety/Depression
journal, May 2009


GABA Depolarization Is Required for Experience-Dependent Synapse Unsilencing in Adult-Born Neurons
journal, April 2013


Neurogenesis in the Striatum of the Adult Human Brain
journal, February 2014


Neurogenesis in the adult human hippocampus
journal, November 1998

  • Eriksson, Peter S.; Perfilieva, Ekaterina; Björk-Eriksson, Thomas
  • Nature Medicine, Vol. 4, Issue 11
  • DOI: 10.1038/3305

Environment complexity stimulates visual cortex neurogenesis: death of a dogma and a research career
journal, October 2001


Functions for adult neurogenesis in memory: An introduction to the neurocomputational approach and to its contribution
journal, February 2012


L-655,708 enhances cognition in rats but is not proconvulsant at a dose selective for α5-containing GABAA receptors
journal, November 2006


Monosynaptic Restriction of Transsynaptic Tracing from Single, Genetically Targeted Neurons
journal, March 2007


VEGF links hippocampal activity with neurogenesis, learning and memory
journal, July 2004

  • Cao, Lei; Jiao, Xiangyang; Zuzga, David S.
  • Nature Genetics, Vol. 36, Issue 8
  • DOI: 10.1038/ng1395

Adult mammalian neurogenesis and the New Zealand white rabbit
journal, March 2008


Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation
journal, April 2011

  • Sahay, Amar; Scobie, Kimberly N.; Hill, Alexis S.
  • Nature, Vol. 472, Issue 7344
  • DOI: 10.1038/nature09817

Estimation of absolute microglial cell numbers in mouse fascia dentata using unbiased and efficient stereological cell counting principles
journal, September 2003

  • Wirenfeldt, Martin; Dalmau, Ishar; Finsen, Bente
  • Glia, Vol. 44, Issue 2
  • DOI: 10.1002/glia.10277

MSK1 regulates environmental enrichment-induced hippocampal plasticity and cognitive enhancement
journal, October 2012

  • Karelina, K.; Hansen, K. F.; Choi, Y. -S.
  • Learning & Memory, Vol. 19, Issue 11
  • DOI: 10.1101/lm.025775.112

Acute Psychosocial Stress Reduces Cell Survival in Adult Hippocampal Neurogenesis without Altering Proliferation
journal, March 2007


Increased blood-brain barrier permeability following acute short-term swimming exercise in conscious normotensive young rats
journal, April 1991

  • Shanker Sharma, Hari; Cervós-Navarro, Jorge; Kumar Dey, Prasanta
  • Neuroscience Research, Vol. 10, Issue 3
  • DOI: 10.1016/0168-0102(91)90058-7

Adherence to a Mediterranean Diet, Cognitive Decline, and Risk of Dementia
journal, August 2009


Environmental enrichment, exercise and corticosterone affect endothelial cell proliferation in adult rat hippocampus and prefrontal cortex
journal, September 2008


Norepinephrine and the dentate gyrus
book, January 2007

  • Harley, Carolyn W.
  • The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications
  • DOI: 10.1016/S0079-6123(07)63018-0

Visualization of neurogenesis in the central nervous system using nestin promoter-GFP transgenic mice
journal, January 2000


Dissociating hippocampal subregions: A double dissociation between dentate gyrus and CA1
journal, January 2001

  • Gilbert, Paul E.; Kesner, Raymond P.; Lee, Inah
  • Hippocampus, Vol. 11, Issue 6
  • DOI: 10.1002/hipo.1077

Astroglia induce neurogenesis from adult neural stem cells
journal, May 2002

  • Song, Hongjun; Stevens, Charles F.; Gage, Fred H.
  • Nature, Vol. 417, Issue 6884
  • DOI: 10.1038/417039a

Running enhances neurogenesis, learning, and long-term potentiation in mice
journal, November 1999

  • van Praag, H.; Christie, B. R.; Sejnowski, T. J.
  • Proceedings of the National Academy of Sciences, Vol. 96, Issue 23
  • DOI: 10.1073/pnas.96.23.13427

Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus
journal, March 2001


Glucocorticoids Orchestrate Divergent Effects on Mood through Adult Neurogenesis
journal, February 2013


Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells
journal, January 2006

  • Butovsky, Oleg; Ziv, Yaniv; Schwartz, Adi
  • Molecular and Cellular Neuroscience, Vol. 31, Issue 1
  • DOI: 10.1016/j.mcn.2005.10.006

Cre/loxP-mediated inactivation of the bHLH transcription factor gene NeuroD/BETA2
journal, January 2005

  • Goebbels, Sandra; Bode, Ulli; Pieper, Alexander
  • genesis, Vol. 42, Issue 4
  • DOI: 10.1002/gene.20138

Acute stress enhances adult rat hippocampal neurogenesis and activation of newborn neurons via secreted astrocytic FGF2
journal, April 2013


Neurons born in the adult dentate gyrus form functional synapses with target cells
journal, July 2008

  • Toni, Nicolas; Laplagne, Diego A.; Zhao, Chunmei
  • Nature Neuroscience, Vol. 11, Issue 8
  • DOI: 10.1038/nn.2156

Running is the neurogenic and neurotrophic stimulus in environmental enrichment
journal, August 2011

  • Kobilo, T.; Liu, Q. -R.; Gandhi, K.
  • Learning & Memory, Vol. 18, Issue 9
  • DOI: 10.1101/lm.2283011

Age-related deficits as working memory load increases: relationships with growth factors
journal, February 2003


Wnt signalling regulates adult hippocampal neurogenesis
journal, October 2005

  • Lie, Dieter-Chichung; Colamarino, Sophia A.; Song, Hong-Jun
  • Nature, Vol. 437, Issue 7063
  • DOI: 10.1038/nature04108

An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus
journal, March 2007

  • Pereira, A. C.; Huddleston, D. E.; Brickman, A. M.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 13
  • DOI: 10.1073/pnas.0611721104

Translating niche-derived signals into neurogenesis: The function of Prox1 in the adult hippocampus
journal, July 2011


More hippocampal neurons in adult mice living in an enriched environment
journal, April 1997

  • Kempermann, Gerd; Kuhn, H. Georg; Gage, Fred H.
  • Nature, Vol. 386, Issue 6624
  • DOI: 10.1038/386493a0

Optical controlling reveals time-dependent roles for adult-born dentate granule cells
journal, November 2012

  • Gu, Yan; Arruda-Carvalho, Maithe; Wang, Jia
  • Nature Neuroscience, Vol. 15, Issue 12
  • DOI: 10.1038/nn.3260

Glial conversion of SVZ-derived committed neuronal precursors after ectopic grafting into the adult brain
journal, May 2006

  • Seidenfaden, Ralph; Desoeuvre, Angélique; Bosio, Andreas
  • Molecular and Cellular Neuroscience, Vol. 32, Issue 1-2
  • DOI: 10.1016/j.mcn.2006.04.003

Monosynaptic Rabies Virus Reveals Premotor Network Organization and Synaptic Specificity of Cholinergic Partition Cells
journal, November 2010


Adult neurogenesis: integrating theories and separating functions
journal, July 2010


Decreased neurogenesis after cholinergic forebrain lesion in the adult rat
journal, July 2004

  • Cooper-Kuhn, Christiana M.; Winkler, J�rgen; Kuhn, H. Georg
  • Journal of Neuroscience Research, Vol. 77, Issue 2
  • DOI: 10.1002/jnr.20116

Early age-related changes in adult hippocampal neurogenesis in C57 mice
journal, January 2010


Nicotine Self-Administration Impairs Hippocampal Plasticity
journal, May 2002


Endogenous Wnt Signaling Maintains Neural Progenitor Cell Potency
journal, May 2009

  • Wexler, Eric M.; Paucer, Andres; Kornblum, Harley I.
  • Stem Cells, Vol. 27, Issue 5
  • DOI: 10.1002/stem.36

Cell-Autonomous Inactivation of the Reelin Pathway Impairs Adult Neurogenesis in the Hippocampus
journal, August 2012


Ablation of hippocampal neurogenesis impairs contextual fear conditioning and synaptic plasticity in the dentate gyrus
journal, November 2006

  • Saxe, M. D.; Battaglia, F.; Wang, J. -W.
  • Proceedings of the National Academy of Sciences, Vol. 103, Issue 46
  • DOI: 10.1073/pnas.0607207103

How widespread is adult neurogenesis in mammals?
journal, June 2007

  • Gould, Elizabeth
  • Nature Reviews Neuroscience, Vol. 8, Issue 6
  • DOI: 10.1038/nrn2147

Loss of Dickkopf-1 Restores Neurogenesis in Old Age and Counteracts Cognitive Decline
journal, February 2013


Fast Synaptic Subcortical Control of Hippocampal Circuits
journal, October 2009


Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells
journal, May 2004


Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment
journal, January 2011

  • Kuzumaki, Naoko; Ikegami, Daigo; Tamura, Rie
  • Hippocampus, Vol. 21, Issue 2
  • DOI: 10.1002/hipo.20775

Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein
journal, May 1995


Neurogenesis in the Neocortex of Adult Primates
journal, October 1999


Generation of a Synthetic Memory Trace
journal, March 2012


Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation
journal, April 1997


Selective lesions of the dentate gyrus produce disruptions in place learning for adjacent spatial locations
journal, March 2012

  • Morris, Andrea M.; Churchwell, John C.; Kesner, Raymond P.
  • Neurobiology of Learning and Memory, Vol. 97, Issue 3
  • DOI: 10.1016/j.nlm.2012.02.005

Neurod1 is essential for the survival and maturation of adult-born neurons
journal, August 2009

  • Gao, Zhengliang; Ure, Kerstin; Ables, Jessica L.
  • Nature Neuroscience, Vol. 12, Issue 9
  • DOI: 10.1038/nn.2385

BDNF Promotes Differentiation and Maturation of Adult-born Neurons through GABAergic Transmission
journal, October 2012


Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling
journal, April 2007


Long-Lasting Plasticity of Hippocampal Adult-Born Neurons
journal, February 2012


Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain
journal, October 2009

  • Clark, Peter J.; Brzezinska, Weronika J.; Puchalski, Emily K.
  • Hippocampus, Vol. 19, Issue 10
  • DOI: 10.1002/hipo.20543

Microglia Modulate Hippocampal Neural Precursor Activity in Response to Exercise and Aging
journal, May 2012


Experimentelle Untersuchungen über das Tetanusgift
journal, December 1891


Neurogenesis in the adult brain: death of a dogma
journal, October 2000

  • Gross, Charles G.
  • Nature Reviews Neuroscience, Vol. 1, Issue 1
  • DOI: 10.1038/35036235

VEGF is necessary for exercise-induced adult hippocampal neurogenesis
journal, November 2003


Pattern Separation: A Common Function for New Neurons in Hippocampus and Olfactory Bulb
journal, May 2011


Transneuronal circuit tracing with neurotropic viruses
journal, December 2008


Endogenous Signaling through  7-Containing Nicotinic Receptors Promotes Maturation and Integration of Adult-Born Neurons in the Hippocampus
journal, June 2010


Neurogenesis in the Caudate Nucleus of the Adult Rabbit
journal, January 2006


Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine
journal, October 2001

  • Czeh, B.; Michaelis, T.; Watanabe, T.
  • Proceedings of the National Academy of Sciences, Vol. 98, Issue 22
  • DOI: 10.1073/pnas.211427898

Dynamics of Hippocampal Neurogenesis in Adult Humans
journal, June 2013


AMPA and NMDA receptor-mediated currents in developing dentate gyrus granule cells
journal, March 2005


Running enhances spatial pattern separation in mice
journal, January 2010

  • Creer, D. J.; Romberg, C.; Saksida, L. M.
  • Proceedings of the National Academy of Sciences, Vol. 107, Issue 5
  • DOI: 10.1073/pnas.0911725107

Identification of Astrocyte-expressed Factors That Modulate Neural Stem/Progenitor Cell Differentiation
journal, June 2006

  • Barkho, Basam Z.; Song, Hongjun; Aimone, James B.
  • Stem Cells and Development, Vol. 15, Issue 3
  • DOI: 10.1089/scd.2006.15.407

Hippocampal synaptic enhancement and information storage within a distributed memory system
journal, January 1987


Resolving New Memories: A Critical Look at the Dentate Gyrus, Adult Neurogenesis, and Pattern Separation
journal, May 2011


Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress
journal, March 1998

  • Gould, E.; Tanapat, P.; McEwen, B. S.
  • Proceedings of the National Academy of Sciences, Vol. 95, Issue 6
  • DOI: 10.1073/pnas.95.6.3168

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants
journal, August 2003


Ciliary Neurotrophic Factor Mediates Dopamine D2 Receptor-Induced CNS Neurogenesis in Adult Mice
journal, February 2008


V1 spinal neurons regulate the speed of vertebrate locomotor outputs
journal, March 2006

  • Gosgnach, Simon; Lanuza, Guillermo M.; Butt, Simon J. B.
  • Nature, Vol. 440, Issue 7081
  • DOI: 10.1038/nature04545

Endothelial Trophic Support of Neuronal Production and Recruitment from the Adult Mammalian Subependyma
journal, June 1999

  • Leventhal, Caroline; Rafii, Shahin; Rafii, Dahlia
  • Molecular and Cellular Neuroscience, Vol. 13, Issue 6
  • DOI: 10.1006/mcne.1999.0762

Bromodeoxyuridine and the Detection of Neurogenesis
journal, June 2007


Short-term and long-term survival of new neurons in the rat dentate gyrus
journal, April 2003

  • Dayer, Alexandre G.; Ford, Abigail A.; Cleaver, Kathryn M.
  • The Journal of Comparative Neurology, Vol. 460, Issue 4
  • DOI: 10.1002/cne.10675

GABAergic Signaling to Newborn Neurons in Dentate Gyrus
journal, December 2005

  • Wadiche, Linda Overstreet; Bromberg, Daniel A.; Bensen, AeSoon L.
  • Journal of Neurophysiology, Vol. 94, Issue 6
  • DOI: 10.1152/jn.00633.2005

Cell migration in the normal and pathological postnatal mammalian brain
journal, May 2009


The action of γ-Aminobutyric acid on cortical neurones
journal, May 1967

  • Krnjević, K.; Schwartz, Susan
  • Experimental Brain Research, Vol. 3, Issue 4
  • DOI: 10.1007/BF00237558

Functional convergence of developmentally and adult-generated granule cells in dentate gyrus circuits supporting hippocampus-dependent memory
journal, September 2010

  • Stone, Scellig S. D.; Teixeira, Cátia M.; Zaslavsky, Kirill
  • Hippocampus, Vol. 21, Issue 12
  • DOI: 10.1002/hipo.20845

GABA Regulates Synaptic Integration of Newly Generated Neurons in the Adult Brain
journal, April 2006


Dynamic Contribution of Nestin-Expressing Stem Cells to Adult Neurogenesis
journal, November 2007


Adult neurogenesis and the plasticity of the dentate gyrus network: Hippocampal remodeling by adult neurogenesis
journal, March 2011


Dentate gyrus neurogenesis and depression
book, January 2007

  • Sahay, Amar; Drew, Michael R.; Hen, Rene
  • The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications
  • DOI: 10.1016/S0079-6123(07)63038-6

A Comparative Approach towards the Understanding of Adult Neurogenesis
journal, January 2001

  • Zupanc, Günther K. H.
  • Brain, Behavior and Evolution, Vol. 58, Issue 5
  • DOI: 10.1159/000057568

What is the mammalian dentate gyrus good for?
journal, July 2008


Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb
journal, March 2013

  • Deshpande, A.; Bergami, M.; Ghanem, A.
  • Proceedings of the National Academy of Sciences, Vol. 110, Issue 12
  • DOI: 10.1073/pnas.1218991110

Mammalian Neural Stem Cells
journal, February 2000


Spatial selectivity of unit activity in the hippocampal granular layer
journal, April 1993


Overview of Dietary Flavonoids: Nomenclature, Occurrence and Intake
journal, October 2003


Signaling in adult neurogenesis
journal, August 2010


Free calcium in heart muscle at rest and during contraction measured with Ca2+-sensitive microelectrodes
journal, August 1980

  • Marban, Eduardo; Rink, Timothy J.; Tsien, Richard W.
  • Nature, Vol. 286, Issue 5776
  • DOI: 10.1038/286845a0

Intake of Flavonoid-Rich Wine, Tea, and Chocolate by Elderly Men and Women Is Associated with Better Cognitive Test Performance
journal, December 2008

  • Nurk, Eha; Refsum, Helga; Drevon, Christian A.
  • The Journal of Nutrition, Vol. 139, Issue 1
  • DOI: 10.3945/jn.108.095182

Modeling new neuron function: a history of using computational neuroscience to study adult neurogenesis: Modeling new neuron function
journal, March 2011


Extrinsic afferent systems to the dentate gyrus
book, January 2007

  • Leranth, Csaba; Hajszan, Tibor
  • The Dentate Gyrus: A Comprehensive Guide to Structure, Function, and Clinical Implications
  • DOI: 10.1016/S0079-6123(07)63004-0

GABA regulates synaptic integration of newly generated neurons in the adult brain
journal, December 2005

  • Ge, Shaoyu; Goh, Eyleen L. K.; Sailor, Kurt A.
  • Nature, Vol. 439, Issue 7076
  • DOI: 10.1038/nature04404

Serotonin and Hippocampal Neurogenesis
journal, August 1999


Dentate Gyrus NMDA Receptors Mediate Rapid Pattern Separation in the Hippocampal Network
journal, July 2007


A subpopulation of precursor cells in the mouse dentate gyrus receives synaptic GABAergic input
journal, June 2005

  • Wang, Li-Ping; Kempermann, Gerd; Kettenmann, Helmut
  • Molecular and Cellular Neuroscience, Vol. 29, Issue 2
  • DOI: 10.1016/j.mcn.2005.02.002

Radiation-induced impairment of hippocampal neurogenesis is associated with cognitive deficits in young mice
journal, August 2004


Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain
journal, August 2008

  • Imayoshi, Itaru; Sakamoto, Masayuki; Ohtsuka, Toshiyuki
  • Nature Neuroscience, Vol. 11, Issue 10
  • DOI: 10.1038/nn.2185

Selective and Quickly Reversible Inactivation of Mammalian Neurons In Vivo Using the Drosophila Allatostatin Receptor
journal, July 2006


Signaling in Adult Neurogenesis
journal, November 2009


Flavonoids and cognitive function: a review of human randomized controlled trial studies and recommendations for future studies
journal, August 2009


Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
journal, May 2005


New Interneurons in the Adult Neocortex: Small, Sparse, but Significant?
journal, April 2008


Expression of BDNF and trkB as a function of age and cognitive performance
journal, November 1998


Pattern Separation in the Dentate Gyrus and CA3 of the Hippocampus
journal, February 2007


Put Them Out to Pasture? What Are Old Granule Cells Good for, Anyway…?
journal, September 2010

  • Aimone, James B.; Deng, Wei; Gage, Fred H.
  • Hippocampus, Vol. 20, Issue 10
  • DOI: 10.1002/hipo.20867

Experience Dictates Stem Cell Fate in the Adult Hippocampus
journal, June 2011


Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb
journal, October 2006


Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme.
journal, November 1979


Works referencing / citing this record:

Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction
journal, January 2019


Phosphofructokinase-1 Negatively Regulates Neurogenesis from Neural Stem Cells
journal, May 2016


The Potential of Stem Cells in Treatment of Traumatic Brain Injury
journal, January 2018


Re-evaluating the link between neuropsychiatric disorders and dysregulated adult neurogenesis
journal, October 2016

  • Yun, Sanghee; Reynolds, Ryan P.; Masiulis, Irene
  • Nature Medicine, Vol. 22, Issue 11
  • DOI: 10.1038/nm.4218

Running Changes the Brain: the Long and the Short of It
journal, November 2017


Review: adult neurogenesis contributes to hippocampal plasticity
journal, November 2017


Nippostrongylus brasiliensis infection inhibits hippocampal neurogenesis in mice
journal, September 2019

  • Sakurai, Masashi; Kurachi, Junya; Sakai, Yusuke
  • Neuropathology, Vol. 39, Issue 6
  • DOI: 10.1111/neup.12596

Revisiting adult neurogenesis and the role of erythropoietin for neuronal and oligodendroglial differentiation in the hippocampus
journal, January 2016

  • Hassouna, I.; Ott, C.; Wüstefeld, L.
  • Molecular Psychiatry, Vol. 21, Issue 12
  • DOI: 10.1038/mp.2015.212

Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells
journal, February 2016

  • Daynac, Mathieu; Morizur, Lise; Chicheportiche, Alexandra
  • Scientific Reports, Vol. 6, Issue 1
  • DOI: 10.1038/srep21505

Protein Palmitoylation Regulates Neural Stem Cell Differentiation by Modulation of EID1 Activity
journal, October 2015


Neurogenesis within the hippocampus after chronic methylphenidate exposure
journal, October 2018

  • Oakes, Hannah V.; DeVee, Carley E.; Farmer, Brandon
  • Journal of Neural Transmission, Vol. 126, Issue 2
  • DOI: 10.1007/s00702-018-1949-2

Ion-channel regulation of response decorrelation in a multi-scale model of the dentate gyrus
journal, July 2019

  • Mishra, Poonam; Narayanan, Rishikesh
  • Current Research in Neurobiology
  • DOI: 10.1101/720078

Effects of addictive drugs on adult neural stem/progenitor cells
journal, October 2015

  • Xu, Chi; Loh, Horace H.; Law, Ping-Yee
  • Cellular and Molecular Life Sciences, Vol. 73, Issue 2
  • DOI: 10.1007/s00018-015-2067-z

Adult Neurogenesis and Psychiatric Disorders
journal, January 2016

  • Kang, Eunchai; Wen, Zhexing; Song, Hongjun
  • Cold Spring Harbor Perspectives in Biology, Vol. 8, Issue 9
  • DOI: 10.1101/cshperspect.a019026

Stem‐Cell‐Driven Growth and Regrowth of the Adult Spinal Cord in Teleost Fish
journal, March 2019

  • Zupanc, Günther K. H.
  • Developmental Neurobiology, Vol. 79, Issue 5
  • DOI: 10.1002/dneu.22672

Evolutionary shifts dramatically reorganized the human hippocampal complex
journal, December 2019

  • Schilder, Brian M.; Petry, Heywood M.; Hof, Patrick R.
  • Journal of Comparative Neurology
  • DOI: 10.1002/cne.24822

Deletion of TLX and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus
journal, October 2017

  • Kozareva, Danka A.; O'Leary, Olivia F.; Cryan, John F.
  • Hippocampus, Vol. 28, Issue 1
  • DOI: 10.1002/hipo.22805

MSCs-Derived Exosomes and Neuroinflammation, Neurogenesis and Therapy of Traumatic Brain Injury
journal, February 2017


Single Cell Isolation and Analysis
journal, October 2016

  • Hu, Ping; Zhang, Wenhua; Xin, Hongbo
  • Frontiers in Cell and Developmental Biology, Vol. 4
  • DOI: 10.3389/fcell.2016.00116

Neuroinflammation and physical exercise as modulators of adult hippocampal neural precursor cell behavior
journal, December 2017

  • Pérez-Domínguez, Martha; Tovar-y-Romo, Luis B.; Zepeda, Angélica
  • Reviews in the Neurosciences, Vol. 29, Issue 1
  • DOI: 10.1515/revneuro-2017-0024

TAM receptors regulate multiple features of microglial physiology
journal, April 2016

  • Fourgeaud, Lawrence; Través, Paqui G.; Tufail, Yusuf
  • Nature, Vol. 532, Issue 7598
  • DOI: 10.1038/nature17630

Born this way: Hippocampal neurogenesis across the lifespan
journal, July 2019

  • Kozareva, Danka A.; Cryan, John F.; Nolan, Yvonne M.
  • Aging Cell, Vol. 18, Issue 5
  • DOI: 10.1111/acel.13007

Smoothened, Stem Cell Maintenance and Brain Diseases
book, January 2014

  • Ruat, Martial; Faure, Hélène; Daynac, Mathieu
  • Topics in Medicinal Chemistry
  • DOI: 10.1007/7355_2014_83

Abolition of aberrant neurogenesis ameliorates cognitive impairment after stroke in mice
journal, February 2019

  • Cuartero, María Isabel; de la Parra, Juan; Pérez-Ruiz, Alberto
  • Journal of Clinical Investigation, Vol. 129, Issue 4
  • DOI: 10.1172/JCI120412

Astrocyte-Derived Paracrine Signals: Relevance for Neurogenic Niche Regulation and Blood–Brain Barrier Integrity
journal, November 2019

  • Spampinato, Simona Federica; Bortolotto, Valeria; Canonico, Pier Luigi
  • Frontiers in Pharmacology, Vol. 10
  • DOI: 10.3389/fphar.2019.01346

RIT1 GTPase Regulates Sox2 Transcriptional Activity and Hippocampal Neurogenesis
journal, February 2017

  • Mir, Sajad; Cai, Weikang; Andres, Douglas A.
  • Journal of Biological Chemistry, Vol. 292, Issue 6
  • DOI: 10.1074/jbc.m116.749770

Gender Differences in the Neurobiology of Anxiety: Focus on Adult Hippocampal Neurogenesis
journal, January 2016

  • Marques, Alessandra Aparecida; Bevilaqua, Mário Cesar do Nascimento; da Fonseca, Alberto Morais Pinto
  • Neural Plasticity, Vol. 2016
  • DOI: 10.1155/2016/5026713

Autophagy is required for performance adaptive response to resistance training and exercise‐induced adult neurogenesis
journal, November 2019

  • Codina‐Martínez, Helena; Fernández‐García, Benjamín; Díez‐Planelles, Carlos
  • Scandinavian Journal of Medicine & Science in Sports, Vol. 30, Issue 2
  • DOI: 10.1111/sms.13586

VEGF preconditioning leads to stem cell remodeling and attenuates age-related decay of adult hippocampal neurogenesis
journal, November 2016

  • Licht, Tamar; Rothe, Gadiel; Kreisel, Tirzah
  • Proceedings of the National Academy of Sciences, Vol. 113, Issue 48
  • DOI: 10.1073/pnas.1609592113

An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury
journal, December 2018

  • Dehler, Sascha; Lou, Wilson Pak-Kin; Gao, Liang
  • Frontiers in Molecular Neuroscience, Vol. 11
  • DOI: 10.3389/fnmol.2018.00443

Adult-generated neurons born during chronic social stress are uniquely adapted to respond to subsequent chronic social stress
journal, January 2018


Human UCB-MSCs treatment upon intraventricular hemorrhage contributes to attenuate hippocampal neuron loss and circuit damage through BDNF-CREB signaling
journal, November 2018


Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF
journal, March 2018


Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures
journal, January 2019

  • Jain, Swati; LaFrancois, John J.; Botterill, Justin J.
  • Hippocampus, Vol. 29, Issue 8
  • DOI: 10.1002/hipo.23062

GSK3β Overexpression in Dentate Gyrus Neural Precursor Cells Expands the Progenitor Pool and Enhances Memory Skills
journal, February 2016

  • Jurado-Arjona, Jerónimo; Llorens-Martín, María; Ávila, Jesús
  • Journal of Biological Chemistry, Vol. 291, Issue 15
  • DOI: 10.1074/jbc.m115.674531

The roles of motor activity and environmental enrichment in intellectual disability
journal, November 2016


Heterogeneities in intrinsic excitability and frequency-dependent response properties of granule cells across the blades of the rat dentate gyrus
journal, February 2020

  • Mishra, Poonam; Narayanan, Rishikesh
  • Journal of Neurophysiology, Vol. 123, Issue 2
  • DOI: 10.1152/jn.00443.2019

Development of Depotentiation in Adult-Born Dentate Granule Cells
journal, October 2019

  • Tao, Xiaoqing; Sun, Ning; Mu, Yangling
  • Frontiers in Cell and Developmental Biology, Vol. 7
  • DOI: 10.3389/fcell.2019.00236

Targeting hippocampal adult neurogenesis using transcription factors to reduce Alzheimer's disease-associated memory impairments
journal, November 2018

  • Dard, Robin F.; Dahan, Lionel; Rampon, Claire
  • Hippocampus, Vol. 29, Issue 7
  • DOI: 10.1002/hipo.23052

T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells
journal, November 2017

  • Beining, Marcel; Mongiat, Lucas Alberto; Schwarzacher, Stephan Wolfgang
  • eLife, Vol. 6
  • DOI: 10.7554/elife.26517

Knockout of Atg5 delays the maturation and reduces the survival of adult-generated neurons in the hippocampus
journal, March 2016


Modulation of Adult Hippocampal Neurogenesis by Sleep: Impact on Mental Health
journal, October 2017

  • Navarro-Sanchis, Cristina; Brock, Olivier; Winsky-Sommerer, Raphaelle
  • Frontiers in Neural Circuits, Vol. 11
  • DOI: 10.3389/fncir.2017.00074

MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation
journal, May 2017


Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus
journal, December 2014

  • Le Bail, Matildé; Martineau, Magalie; Sacchi, Silvia
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 2
  • DOI: 10.1073/pnas.1416668112

Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer’s Disease
journal, December 2019

  • Parodi-Rullán, Rebecca; Sone, Je Yeong; Fossati, Silvia
  • Journal of Alzheimer's Disease, Vol. 72, Issue 4
  • DOI: 10.3233/jad-190357

Neuroplasticity and Clinical Practice: Building Brain Power for Health
journal, July 2016


Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles
journal, February 2016


Prdm16 is required for the maintenance of neural stem cells in the postnatal forebrain and their differentiation into ependymal cells
journal, June 2017

  • Shimada, Issei S.; Acar, Melih; Burgess, Rebecca J.
  • Genes & Development, Vol. 31, Issue 11
  • DOI: 10.1101/gad.291773.116

Rhythms and blues: modulation of oscillatory synchrony and the mechanism of action of antidepressant treatments: Oscillatory synchrony and antidepressant treatments
journal, March 2015

  • Leuchter, Andrew F.; Hunter, Aimee M.; Krantz, David E.
  • Annals of the New York Academy of Sciences, Vol. 1344, Issue 1
  • DOI: 10.1111/nyas.12742

Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways
journal, October 2019

  • Horgusluoglu-Moloch, Emrin; Risacher, Shannon L.; Crane, Paul K.
  • Scientific Reports, Vol. 9, Issue 1
  • DOI: 10.1038/s41598-019-50507-3

Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity
journal, December 2014

  • Calabrese, Francesca; Rossetti, Andrea C.; Racagni, Giorgio
  • Frontiers in Cellular Neuroscience, Vol. 8
  • DOI: 10.3389/fncel.2014.00430

Development of Microplatforms to Mimic the In Vivo Architecture of CNS and PNS Physiology and Their Diseases
journal, June 2018


Neurogenesis: remembering all or forgetting some
journal, June 2018


Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained: Aerobic exercise promotes adult neurogenesis
journal, February 2016

  • Nokia, Miriam S.; Lensu, Sanna; Ahtiainen, Juha P.
  • The Journal of Physiology, Vol. 594, Issue 7
  • DOI: 10.1113/jp271552

The systemic environment: at the interface of aging and adult neurogenesis
journal, November 2017

  • Smith, Lucas K.; White, Charles W.; Villeda, Saul A.
  • Cell and Tissue Research, Vol. 371, Issue 1
  • DOI: 10.1007/s00441-017-2715-8

Developmental dynamics of neurogenesis and gliogenesis in the postnatal mammalian brain in health and disease: Historical and future perspectives
journal, December 2019

  • Nakafuku, Masato; Águila, Ángela
  • WIREs Developmental Biology, Vol. 9, Issue 3
  • DOI: 10.1002/wdev.369

A Combinatorial Model for Dentate Gyrus Sparse Coding
journal, January 2017

  • Severa, William; Parekh, Ojas; James, Conrad D.
  • Neural Computation, Vol. 29, Issue 1
  • DOI: 10.1162/neco_a_00905

Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain
journal, January 2020


The systemic environment: at the interface of aging and adult neurogenesis
journal, November 2017

  • Smith, Lucas K.; White, Charles W.; Villeda, Saul A.
  • Cell and Tissue Research, Vol. 371, Issue 1
  • DOI: 10.1007/s00441-017-2715-8

BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
journal, June 2017

  • Kowiański, Przemysław; Lietzau, Grażyna; Czuba, Ewelina
  • Cellular and Molecular Neurobiology, Vol. 38, Issue 3
  • DOI: 10.1007/s10571-017-0510-4

Ischemic Injury Does Not Stimulate Striatal Neuron Replacement Even during Periods of Active Striatal Neurogenesis
journal, June 2020


MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke
journal, January 2018


Microglia-derived IL-1β triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells
journal, June 2015


Knockout of Atg5 delays the maturation and reduces the survival of adult-generated neurons in the hippocampus
journal, March 2016


TAM receptors regulate multiple features of microglial physiology
journal, April 2016

  • Fourgeaud, Lawrence; Través, Paqui G.; Tufail, Yusuf
  • Nature, Vol. 532, Issue 7598
  • DOI: 10.1038/nature17630

Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors
journal, March 2017

  • Jongbloets, Bart C.; Lemstra, Suzanne; Schellino, Roberta
  • Nature Communications, Vol. 8, Issue 1
  • DOI: 10.1038/ncomms14666

Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
journal, March 2020


Spatial geometry of stem cell proliferation in the adult hippocampus
journal, February 2018


BMP and WNT signalling cooperate through LEF1 in the neuronal specification of adult hippocampal neural stem and progenitor cells
journal, June 2018


Growth Differentiation Factor 11 treatment leads to neuronal and vascular improvements in the hippocampus of aged mice
journal, November 2018


Genome-wide association analysis of hippocampal volume identifies enrichment of neurogenesis-related pathways
journal, October 2019

  • Horgusluoglu-Moloch, Emrin; Risacher, Shannon L.; Crane, Paul K.
  • Scientific Reports, Vol. 9, Issue 1
  • DOI: 10.1038/s41598-019-50507-3

RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function
journal, December 2015

  • Wang, Han-Ying; Hsieh, Pei-Fen; Huang, De-Fong
  • Scientific Reports, Vol. 5, Issue 1
  • DOI: 10.1038/srep17383

Age-related neurogenesis decline in the subventricular zone is associated with specific cell cycle regulation changes in activated neural stem cells
journal, February 2016

  • Daynac, Mathieu; Morizur, Lise; Chicheportiche, Alexandra
  • Scientific Reports, Vol. 6, Issue 1
  • DOI: 10.1038/srep21505

Time-lapse imaging reveals highly dynamic structural maturation of postnatally born dentate granule cells in organotypic entorhino-hippocampal slice cultures
journal, March 2017

  • Radic, Tijana; Jungenitz, Tassilo; Singer, Mathias
  • Scientific Reports, Vol. 7, Issue 1
  • DOI: 10.1038/srep43724

Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis
journal, April 2017

  • Lugert, S.; Kremer, T.; Jagasia, R.
  • Scientific Reports, Vol. 7, Issue 1
  • DOI: 10.1038/srep46543

Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus
journal, December 2014

  • Le Bail, Matildé; Martineau, Magalie; Sacchi, Silvia
  • Proceedings of the National Academy of Sciences, Vol. 112, Issue 2
  • DOI: 10.1073/pnas.1416668112

Noggin rescues age-related stem cell loss in the brain of senescent mice with neurodegenerative pathology
journal, October 2018

  • Díaz-Moreno, María; Armenteros, Tomás; Gradari, Simona
  • Proceedings of the National Academy of Sciences, Vol. 115, Issue 45
  • DOI: 10.1073/pnas.1813205115

Dlk1 dosage regulates hippocampal neurogenesis and cognition
journal, March 2021

  • Montalbán-Loro, Raquel; Lassi, Glenda; Lozano-Ureña, Anna
  • Proceedings of the National Academy of Sciences, Vol. 118, Issue 11
  • DOI: 10.1073/pnas.2015505118

Neural stem cell lineage-specific cannabinoid type-1 receptor regulates neurogenesis and plasticity in the adult mouse hippocampus
journal, October 2018

  • Zimmermann, Tina; Maroso, Mattia; Beer, Annika
  • Cerebral Cortex, Vol. 28, Issue 12
  • DOI: 10.1093/cercor/bhy258

Top-down inputs drive neuronal network rewiring and context-enhanced sensory processing in olfaction
journal, February 2018

  • Adams, Wayne; Graham, James N.; Han, Xuchen
  • PLOS Computational Biology
  • DOI: 10.1101/271197

Resilience to cognitive aging is associated with responsiveness of dentate neurons generated throughout adult life
posted_content, January 2020

  • Montaron, Marie-Francoise; Charrier, VAnessa; Blin, Nicolas
  • BioRxiv
  • DOI: 10.1101/290676

An immune-CNS axis activates remote hippocampal stem cells following Spinal Transection Injury
journal, July 2018

  • Dehler, Sascha; Lou, Pak-Kin; Skabkin, Maxim
  • Frontiers in Molecular Neuroscience
  • DOI: 10.1101/361535

Evidence for reduced neurogenesis in the aging human hippocampus despite stable stem cell markers
journal, August 2017

  • Mathews, Kathryn J.; Allen, Katherine M.; Boerrigter, Danny
  • Aging Cell, Vol. 16, Issue 5
  • DOI: 10.1111/acel.12641

Born this way: Hippocampal neurogenesis across the lifespan
journal, July 2019

  • Kozareva, Danka A.; Cryan, John F.; Nolan, Yvonne M.
  • Aging Cell, Vol. 18, Issue 5
  • DOI: 10.1111/acel.13007

Heterogeneities in intrinsic excitability and frequency-dependent response properties of granule cells across the blades of the rat dentate gyrus
journal, February 2020

  • Mishra, Poonam; Narayanan, Rishikesh
  • Journal of Neurophysiology, Vol. 123, Issue 2
  • DOI: 10.1152/jn.00443.2019

Human UCB-MSCs treatment upon intraventricular hemorrhage contributes to attenuate hippocampal neuron loss and circuit damage through BDNF-CREB signaling
journal, November 2018


Transmembrane protein 108 involves in adult neurogenesis in the hippocampal dentate gyrus
journal, January 2019


Single cell sequencing of radial glia progeny reveals diversity of newborn neurons in the adult zebrafish brain
journal, January 2020


ADrosophilamodel to investigate the neurotoxic side effects of radiation exposure
journal, July 2015

  • Sudmeier, Lisa J.; Howard, Steven P.; Ganetzky, Barry
  • Disease Models & Mechanisms, Vol. 8, Issue 7
  • DOI: 10.1242/dmm.019786

Aerobic Fitness and Neurocognitive Function Scores in Young Faroese Adults and Potential Modification by Prenatal Methylmercury Exposure
journal, April 2017

  • Oulhote, Youssef; Debes, Frodi; Vestergaard, Sonja
  • Environmental Health Perspectives, Vol. 125, Issue 4
  • DOI: 10.1289/ehp274

Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory
journal, June 2015


MiR-338-3p regulates neuronal maturation and suppresses glioblastoma proliferation
journal, May 2017


Hippocampal neurogenesis and volume in migrating and wintering semipalmated sandpipers (Calidris pusilla)
journal, June 2017

  • de Morais Magalhães, Nara Gyzely; Guerreiro Diniz, Cristovam; Guerreiro Diniz, Daniel
  • PLOS ONE, Vol. 12, Issue 6
  • DOI: 10.1371/journal.pone.0179134

Dominance behaviour in a non-aggressive flatfish, Senegalese sole (Solea senegalensis) and brain mRNA abundance of selected transcripts
journal, September 2017


Impaired neuronal maturation of hippocampal neural progenitor cells in mice lacking CRAF
journal, March 2018


Functional Integration of Adult-Born Hippocampal Neurons after Traumatic Brain Injury
journal, September 2015


BACE1 Regulates Proliferation and Neuronal Differentiation of Newborn Cells in the Adult Hippocampus in Mice
journal, July 2018


Switching roles: the functional plasticity of adult tissue stem cells
journal, March 2015


The rostral migratory stream generates hippocampal CA1 pyramidal-like neurons in a novel organotypic slice co-culture model
text, January 2015


Impact of Swiprosin-1/Efhd2 on Adult Hippocampal Neurogenesis
text, January 2018

  • Regensburger, Martin; Prots, Iryna; Reimer, Dorothea
  • Charité - Universitätsmedizin Berlin
  • DOI: 10.17169/refubium-24279

Chronic pain and adult hippocampal neurogenesis: translational implications from preclinical studies
journal, September 2017


Stress, Depression, Resilience and Ageing: A Role for the LPA-LPA1 Pathway
journal, March 2018


Mitochondrial Metabolism-Mediated Regulation of Adult Neurogenesis
journal, November 2017


Single Cell Isolation and Analysis
journal, October 2016

  • Hu, Ping; Zhang, Wenhua; Xin, Hongbo
  • Frontiers in Cell and Developmental Biology, Vol. 4
  • DOI: 10.3389/fcell.2016.00116

Rewiring of Memory Circuits: Connecting Adult Newborn Neurons With the Help of Microglia
journal, March 2019

  • Rodríguez-Iglesias, Noelia; Sierra, Amanda; Valero, Jorge
  • Frontiers in Cell and Developmental Biology, Vol. 7
  • DOI: 10.3389/fcell.2019.00024

Development of Depotentiation in Adult-Born Dentate Granule Cells
journal, October 2019

  • Tao, Xiaoqing; Sun, Ning; Mu, Yangling
  • Frontiers in Cell and Developmental Biology, Vol. 7
  • DOI: 10.3389/fcell.2019.00236

The Mineralocorticoid Agonist Fludrocortisone Promotes Survival and Proliferation of Adult Hippocampal Progenitors
journal, June 2016

  • Gesmundo, Iacopo; Villanova, Tania; Gargantini, Eleonora
  • Frontiers in Endocrinology, Vol. 7
  • DOI: 10.3389/fendo.2016.00066

Role of physical and mental training in brain network configuration
journal, June 2015


Differential Change in Hippocampal Radial Astrocytes and Neurogenesis in Shorebirds With Contrasting Migratory Routes
journal, September 2019

  • Mendes de Lima, Camila; Douglas Corrêa Pereira, Patrick; Pereira Henrique, Ediely
  • Frontiers in Neuroanatomy, Vol. 13
  • DOI: 10.3389/fnana.2019.00082

Social Plasticity Relies on Different Neuroplasticity Mechanisms across the Brain Social Decision-Making Network in Zebrafish
journal, February 2016

  • Teles, Magda C.; Cardoso, Sara D.; Oliveira, Rui F.
  • Frontiers in Behavioral Neuroscience, Vol. 10
  • DOI: 10.3389/fnbeh.2016.00016

Sex Differences in Stress and Group Housing Effects on the Number of Newly Proliferated Cells and Neuroblasts in Middle-Aged Dentate Gyrus
journal, January 2017

  • Tzeng, Wen-Yu; Wu, Hsin-Hua; Wang, Ching-Yi
  • Frontiers in Behavioral Neuroscience, Vol. 10
  • DOI: 10.3389/fnbeh.2016.00249

Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity
journal, December 2014

  • Calabrese, Francesca; Rossetti, Andrea C.; Racagni, Giorgio
  • Frontiers in Cellular Neuroscience, Vol. 8
  • DOI: 10.3389/fncel.2014.00430

Involvement of calpains in adult neurogenesis: implications for stroke
journal, February 2015

  • Machado, Vanessa M.; Morte, Maria I.; Carreira, Bruno P.
  • Frontiers in Cellular Neuroscience, Vol. 9
  • DOI: 10.3389/fncel.2015.00022

Osteogenic and Neurogenic Stem Cells in Their Own Place: Unraveling Differences and Similarities Between Niches
journal, November 2015

  • Lattanzi, Wanda; Parolisi, Roberta; Barba, Marta
  • Frontiers in Cellular Neuroscience, Vol. 9
  • DOI: 10.3389/fncel.2015.00455

Exosomes as Novel Regulators of Adult Neurogenic Niches
journal, January 2016

  • Bátiz, Luis Federico; Castro, Maite A.; Burgos, Patricia V.
  • Frontiers in Cellular Neuroscience, Vol. 9
  • DOI: 10.3389/fncel.2015.00501

MSCs-Derived Exosomes and Neuroinflammation, Neurogenesis and Therapy of Traumatic Brain Injury
journal, February 2017


Abnormal Development of Dendrites in Adult-Born Rat Hippocampal Granule Cells Induced by Cyclophosphamide
journal, June 2017


Adult neurogenesis 20 years later: physiological function vs. brain repair
journal, March 2015


Altered Hippocampal Neurogenesis and Amygdalar Neuronal Activity in Adult Mice with Repeated Experience of Aggression
journal, December 2015

  • Smagin, Dmitry A.; Park, June-Hee; Michurina, Tatyana V.
  • Frontiers in Neuroscience, Vol. 9
  • DOI: 10.3389/fnins.2015.00443

Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles
journal, February 2016


Adult Neurogenesis 50 Years Later: Limits and Opportunities in Mammals
journal, February 2016


Tamoxifen Activation of Cre-Recombinase Has No Persisting Effects on Adult Neurogenesis or Learning and Anxiety
journal, February 2017

  • Rotheneichner, Peter; Romanelli, Pasquale; Bieler, Lara
  • Frontiers in Neuroscience, Vol. 11
  • DOI: 10.3389/fnins.2017.00027

From Mice to Mole-Rats: Species-Specific Modulation of Adult Hippocampal Neurogenesis
journal, October 2017


Decreased Hippocampal Neuroplasticity and Behavioral Impairment in an Animal Model of Inhalant Abuse
journal, February 2018


Radiation Induces Distinct Changes in Defined Subpopulations of Neural Stem and Progenitor Cells in the Adult Hippocampus
journal, January 2019

  • Mineyeva, Olga A.; Bezriadnov, Dmitri V.; Kedrov, Alexander V.
  • Frontiers in Neuroscience, Vol. 12
  • DOI: 10.3389/fnins.2018.01013

Ginseng-Angelica-Sansheng-Pulvis Boosts Neurogenesis Against Focal Cerebral Ischemia-Induced Neurological Deficiency
journal, May 2019


Calpastatin Overexpression Preserves Cognitive Function Following Seizures, While Maintaining Post-Injury Neurogenesis
journal, March 2017

  • Machado, Vanessa M.; Lourenço, Ana Sofia; Florindo, Cláudia
  • Frontiers in Molecular Neuroscience, Vol. 10
  • DOI: 10.3389/fnmol.2017.00060

RNA-Sequencing Reveals Unique Transcriptional Signatures of Running and Running-Independent Environmental Enrichment in the Adult Mouse Dentate Gyrus
journal, April 2018

  • Grégoire, Catherine-Alexandra; Tobin, Stephanie; Goldenstein, Brianna L.
  • Frontiers in Molecular Neuroscience, Vol. 11
  • DOI: 10.3389/fnmol.2018.00126

An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury
journal, December 2018

  • Dehler, Sascha; Lou, Wilson Pak-Kin; Gao, Liang
  • Frontiers in Molecular Neuroscience, Vol. 11
  • DOI: 10.3389/fnmol.2018.00443

Intrinsic Cholinergic Neurons in the Hippocampus: Fact or Artifact?
journal, March 2016


DISC1-mediated dysregulation of adult hippocampal neurogenesis in rats
journal, June 2015

  • Lee, Heekyung; Kang, Eunchai; GoodSmith, Douglas
  • Frontiers in Systems Neuroscience, Vol. 9
  • DOI: 10.3389/fnsys.2015.00093

Adult hippocampal neurogenesis and pattern separation in DG: a role for feedback inhibition in modulating sparseness to govern population-based coding
journal, August 2015

  • McAvoy, Kathleen; Besnard, Antoine; Sahay, Amar
  • Frontiers in Systems Neuroscience, Vol. 9
  • DOI: 10.3389/fnsys.2015.00120

Opiate Analgesics as Negative Modulators of Adult Hippocampal Neurogenesis: Potential Implications in Clinical Practice
journal, May 2017


Astrocyte-Derived Paracrine Signals: Relevance for Neurogenic Niche Regulation and Blood–Brain Barrier Integrity
journal, November 2019

  • Spampinato, Simona Federica; Bortolotto, Valeria; Canonico, Pier Luigi
  • Frontiers in Pharmacology, Vol. 10
  • DOI: 10.3389/fphar.2019.01346

Neuroplasticity and Clinical Practice: Building Brain Power for Health
journal, July 2016


Thinking after Drinking: Impaired Hippocampal-Dependent Cognition in Human Alcoholics and Animal Models of Alcohol Dependence
journal, September 2016


Brain Plasticity in Mammals: An Example for the Role of Comparative Medicine in the Neurosciences
journal, November 2018


The Possible Roles of the Dentate Granule Cell’s Leptin and Other Ciliary Receptors in Alzheimer’s Neuropathology
journal, July 2015

  • Whitfield, James; Chiarini, Anna; Dal Prà, Ilaria
  • Cells, Vol. 4, Issue 3
  • DOI: 10.3390/cells4030253

Development of Microplatforms to Mimic the In Vivo Architecture of CNS and PNS Physiology and Their Diseases
journal, June 2018


α-Tocopherol and Hippocampal Neural Plasticity in Physiological and Pathological Conditions
journal, December 2016

  • Ambrogini, Patrizia; Betti, Michele; Galati, Claudia
  • International Journal of Molecular Sciences, Vol. 17, Issue 12
  • DOI: 10.3390/ijms17122107

Newly Generated and Non-Newly Generated “Immature” Neurons in the Mammalian Brain: A Possible Reservoir of Young Cells to Prevent Brain Aging and Disease?
journal, May 2019

  • La Rosa, Chiara; Ghibaudi, Marco; Bonfanti, Luca
  • Journal of Clinical Medicine, Vol. 8, Issue 5
  • DOI: 10.3390/jcm8050685

Protective effects of ethyl pyruvate on lipopolysaccharide-induced acute lung injury through inhibition of autophagy in neutrophils
journal, January 2017

  • Zhu, Qingteng; Wang, Hui; Wang, Hairong
  • Molecular Medicine Reports, Vol. 15, Issue 3
  • DOI: 10.3892/mmr.2017.6118

Novel insights into the role of NF-κB p50 in astrocyte-mediated fate specification of adult neural progenitor cells
journal, January 2017


Molecular Mechanism of Adult Neurogenesis and its Association with Human Brain Diseases
journal, January 2016


The Role of Adult Hippocampal Neurogenesis in Learning and Memory Function
journal, December 2016

  • Kaptan, Zülal; Üzüm, Gülay
  • Turkish Journal Of Neurology, Vol. 22, Issue 4
  • DOI: 10.4274/tnd.68889

Repeated restraint stress promotes hippocampal neuronal cell ciliogenesis and proliferation in mice
journal, January 2018


T2N as a new tool for robust electrophysiological modeling demonstrated for mature and adult-born dentate granule cells
journal, November 2017

  • Beining, Marcel; Mongiat, Lucas Alberto; Schwarzacher, Stephan Wolfgang
  • eLife, Vol. 6
  • DOI: 10.7554/elife.26517