Extrinsic Noise Driven Phenotype Switching in a Self-Regulating Gene

Assaf, Michael; Roberts, Elijah; Luthey-Schulten, Zaida; Goldenfeld, Nigel

doi:10.1103/PhysRevLett.111.058102

Title: Extrinsic Noise Driven Phenotype Switching in a Self-Regulating Gene

Full Record
Other Related Research

Authors:: Assaf, Michael; Roberts, Elijah; Luthey-Schulten, Zaida; Goldenfeld, Nigel

Publication Date:: Tue Jul 30 00:00:00 EDT 2013

Sponsoring Org.:: USDOE

OSTI Identifier:: 1104343

Resource Type:: Publisher's Accepted Manuscript

Journal Name:: Physical Review Letters

Additional Journal Information:: Journal Volume: 111; Journal Issue: 5; Journal ID: ISSN 0031-9007

Publisher:: American Physical Society

Country of Publication:: United States

Language:: English

Citation Formats


                    Assaf, Michael, Roberts, Elijah, Luthey-Schulten, Zaida, and Goldenfeld, Nigel. Extrinsic Noise Driven Phenotype Switching in a Self-Regulating Gene.  United States: N. p., 2013. 
Web.  doi:10.1103/PhysRevLett.111.058102.

Copy to clipboard


                    Assaf, Michael, Roberts, Elijah, Luthey-Schulten, Zaida, & Goldenfeld, Nigel. Extrinsic Noise Driven Phenotype Switching in a Self-Regulating Gene.  United States.  https://doi.org/10.1103/PhysRevLett.111.058102

Copy to clipboard


                    Assaf, Michael, Roberts, Elijah, Luthey-Schulten, Zaida, and Goldenfeld, Nigel. Tue .  
"Extrinsic Noise Driven Phenotype Switching in a Self-Regulating Gene".  United States.  https://doi.org/10.1103/PhysRevLett.111.058102.

Copy to clipboard


                    
@article{osti_1104343,

  title        = {Extrinsic Noise Driven Phenotype Switching in a Self-Regulating Gene},

  author       = {Assaf, Michael and Roberts, Elijah and Luthey-Schulten, Zaida and Goldenfeld, Nigel},

  abstractNote = {},

  doi          = {10.1103/PhysRevLett.111.058102},

  journal      = {Physical Review Letters},

  number       = 5,

  volume       = 111,

  place        = {United States},

  year         = {Tue Jul 30 00:00:00 EDT 2013},

  month        = {Tue Jul 30 00:00:00 EDT 2013}

}

Copy to clipboard

Journal Article:

Free Publicly Available Full Text

Accepted Manuscript (Publisher)

Publisher's Version of Record
https://doi.org/10.1103/PhysRevLett.111.058102

Other availability

Search WorldCat to find libraries that may hold this journal

Citation Metrics:

Cited by: 65 works

Citation information provided by
Web of Science

Save / Share:

Export Metadata

Save to My Library

Similar Records in DOE PAGES and OSTI.GOV collections:

Quantifying Extrinsic Noise in Gene Expression Using the Maximum Entropy Framework

Journal Article Dixit, Purushottam D. - Biophysical Journal
https://doi.org/10.1016/j.bpj.2013.05.010
Genetic Selection for Context-Dependent Stochastic Phenotypes: Sp1 and TATA Mutations Increase Phenotypic Noise in HIV-1 Gene Expression

Journal Article Miller-Jensen, Kathryn ; Skupsky, Ron ; Shah, Priya S. ; ... - PLoS Computational Biology (Online)

The sequence of a promoter within a genome does not uniquely determine gene expression levels and their variability; rather, promoter sequence can additionally interact with its location in the genome, or genomic context, to shape eukaryotic gene expression. Retroviruses, such as human immunodeficiency virus-1 (HIV), integrate their genomes into those of their host and thereby provide a biomedically-relevant model system to quantitatively explore the relationship between promoter sequence, genomic context, and noise-driven variability on viral gene expression. Using an in vitro model of the HIV Tat-mediated positive-feedback loop, we previously demonstrated that fluctuations in viral Tattransactivating protein levels generate integration-site-dependent,more »« less
https://doi.org/10.1371/journal.pcbi.1003135

Full Text Available
Statistical ensemble analysis for simulating extrinsic noise-driven response in NF-κB signaling networks

Journal Article Joo, Jaewook ; Plimpton, Steven J. ; Faulon, Jean-Loup - BMC Systems Biology

Background: Gene expression profiles and protein dynamics in single cells have a large cell-to-cell variability due to intracellular noise. Intracellular fluctuations originate from two sources: intrinsic noise due to the probabilistic nature of biochemical reactions and extrinsic noise due to randomized interactions of the cell with other cellular systems or its environment. Presently, there is no systematic parameterization and modeling scheme to simulate cellular response at the single cell level in the presence of extrinsic noise. Results: In this paper, we propose a novel statistical ensemble method to simulate the distribution of heterogeneous cellular responses in single cells. We capturemore »« less
https://doi.org/10.1186/1752-0509-7-45

Full Text Available
MicroRNA-31 controls phenotypic modulation of human vascular smooth muscle cells by regulating its target gene cellular repressor of E1A-stimulated genes

Journal Article Wang, Jie ; Cardiovascular Research Institute and Key Laboratory of Cardiology, Shenyang Northern Hospital, Shenyang 110840 ; Yan, Cheng-Hui ; ... - Experimental Cell Research

Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a critical role in the pathogenesis of a variety of proliferative vascular diseases. The cellular repressor of E1A-stimulated genes (CREG) has been shown to play an important role in phenotypic modulation of VSMCs. However, the mechanism regulating CREG upstream signaling remains unclear. MicroRNAs (miRNAs) have recently been found to play a critical role in cell differentiation via target-gene regulation. This study aimed to identify a miRNA that binds directly to CREG, and may thus be involved in CREG-mediated VSMC phenotypic modulation. Computational analysis indicated that miR-31 bound to the CREG mRNAmore »« less
https://doi.org/10.1016/J.YEXCR.2013.03.010
Teniposide regulates the phenotype switching of vascular smooth muscle cells in a miR-21-dependent manner

Journal Article Han, Hao ; Yang, Shu ; Liang, Yu ; ... - Biochemical and Biophysical Research Communications

Highlights: • Teniposide induces expression of VSMC contractile markers in aortic lesion plaques and HASMCs. • Teniposide inhibits VSMC phenotype switching by inducing miR-21 expression. • Teniposide ameliorates ligation-induced carotid artery remodeling in C57BL/6J mice. • The anti-vascular remodeling effect of teniposide suggests the potential application of Topo II inhibitors on occlusive vascular diseases. The switch of vascular smooth muscle cells (SMCs) from the contractile phenotype to proliferative one can make contributions to atherosclerosis and neointima formation. MiR-21 can prevent the rupture of advanced lesion plaques. We previously reported the protection of DNA topoisomerase II (Topo II) inhibitors against atherosclerosismore »« less
https://doi.org/10.1016/J.BBRC.2018.10.198

Similar Records