Document Details
PURL
Title:
THE INFLUENCE OF PROTRACTED X-IRRADIATION ON THE INTESTINE OF RATS PROTECTED BY CYSTEINE AND PARTIAL BODY SHIELDING
Author(s):
Subject Terms:
CYSTEINERADIATION AND RADIATION PROTECTIONRATS - RADIATION EFFECTS
Document Location:
DOE Public Reading Room - Hanford Battelle P.O. Box 999 MS H2-53 Richland WA 99352 (509)372-7443
Document Type:
REPORT
Publication Date:
1964 Apr 27
Declassification Status:
Declassified
Document Pages:
19
Accession Number:
RL-1-382415
Document Number(s):
HW-SA-3498
Originating Research Org.:
GE - HAPO
OpenNet Entry Date:
2004 Feb 24
OpenNet Modified Date:
2015 Jul 17
Description/Abstract:
SURVIVAL OF RATS AFTER FRACTIONATED WHOLE-BODY X-IRRADIATION WITH INDIVIDUAL DOSES UP TO 500 R WAS NOT LIMITED BY INTESTINAL DAMAGE, NOR WAS IT INCREASED APPRECIABLY BY PRETREATMENT WITH CYSTEINE. PROTECTION OF HEMATOPOIETIC TISSUE BY SHIELDING THE THORACIC REGION OR BY SHIELDING ALL OF THE BODY, EXCEPT THE ABDOMEN, INCREASED SURVIVAL SO THE RESISITANCE OF THE INTESTINE TO PROTRACTED RADIAITON COULD BE STUDIED. CYSTEINE PROPHYLAXIS, IN THE PRESENCE OF PARTIAL-BODY SHIELDING, CAUSED A DOSE REDUCTION FACTOR OF ABOUT 2 IN DECREASING INTESTINAL DAMAGE AND INCREASING SURVIVAL FROM SEMI-WEEKLY X-IRRADIATION.