Document Details
PURL
Title:
BRONCHIOLO-ALVEOLAR TUMORS OF THE CANINE LUNG FOLLOWING PLUTONIUM PARTICLE INHALATION (FIGURES 1,2,3 NOT INCLUDED)
Author(s):
Subject Terms:
DOGS - RADIATION EFFECTSLUNGS - RADIATION EFFECTSPLUTONIUM - BIOLOGICAL EFFECTSRADIOBIOLOGY
Document Location:
DOE Public Reading Room - Hanford Battelle P.O. Box 999 MS H2-53 Richland WA 99352 (509)372-7443
Document Type:
REPORT
Publication Date:
1964 Mar 27
Declassification Status:
Declassified
Document Pages:
7
Accession Number:
RL-1-382382
Document Number(s):
HW-SA-3445
Originating Research Org.:
GE - HAPO
OpenNet Entry Date:
2004 Feb 24
OpenNet Modified Date:
2015 Aug 24
Description/Abstract:
INHALATION OF PU PARTICLES CAUSED SPONTANEOUS DEATHS AT 55 TO 1446 DAYS POST-EXPOSURE IN BEAGLE DOGS HAVING A LUNG BURDEN OF FROM 0.6 TO 48 UC PU-239 02. 4 DOGS SURVIVING MORE THAN 1150 DAYS, AND 1 ANIMAL THAT DIED 150 DAYS AFTER EXPOSURE TO HIGH LEVELS OF PU AEROSOLS, SHOWED BRONCHIOLO-ALVEOLAR TUMORS. THOUGH MOST OF THESE NEOPLASMS WERE LOCALLY INVASIVE, AND SOME APPREARED TO BE OF MULTICENTRIC ORIGIN, NO EVIDENCE OF REGIONAL OR DISTAL METASTASIS WAS SEEN. THE PROGRESSION SEQUENCE OF TUMOR FORMATION APPREARED TO BE DESMOPLASIA, METAPLASIA, AND FINALLY NEOPLASIA.