Document Details
PURL
Title:
DEPOSITION AND RETENTION OF RU-106 FOLLOWING ADMINISTRATION OF RU-106-O2 TO MICE BY INHALATION AND INTRATRACHEAL INJECTION
Author(s):
Subject Terms:
ATMOSHPERE EXPOSURE CHAMBERSDESIGNLUNGSPARTICLE RETENTIONRADIATION AND RADIATION PROTECTIONRUTHENIUMTISSUE DISTRIBUTION
Document Location:
DOE Public Reading Room - Hanford Battelle P.O. Box 999 MS H2-53 Richland WA 99352 (509)372-7443
Document Type:
REPORT
Publication Date:
1957 Oct 01
Declassification Status:
Declassified
Document Pages:
24
Accession Number:
RL-1-366137
Document Number(s):
HW-52285
Originating Research Org.:
GE - HAPO
OpenNet Entry Date:
2004 Feb 24
OpenNet Modified Date:
2015 Aug 10
Description/Abstract:
THE DEPOSITION AND RETENTION OF RU-106 IN MICE FOLLOWING INHALATION OF RU-106-O2 AS DUST AND AS A FOG WERE STUDIED FOR TWO DAYS FOLLOWING EXPOSURE. ALMOST 25% OF THE RUTHENIUM OXIDE INHALED WAS PRESENT IN THE LUNGS IMMEDIATELY AFTER EXPOSRUE. THIS WAS REDUCED BY HALF IN 24 HOURS. THE REMAINDER WAS REMOVED FROM THE LUNG AT A MUCH SLOWER RATE. INHALATION OF RUTHENIUM OXIDE PARTICLES WAS COMPARED WITH ADMINISTRATION BY INTRATRACHEAL INJECTION. INHALATION PRODUCED MORE UNIFORM DISTRIBUTION OF PARTICLES IN THE LUNG THAN DID ADMISISTRATION BY INTRATRACHEAL INJECTION AND MUCH GREATER DISTRIBUTION OF RU-106 TO TISSUES OTHER THAN THE LUNG. THIS WAS ATTRIBUTED TO THE LARGER QUANTITIES OF PARTICLES PASSING THROUGH THE GASTOINTESTIONAL TRACT. THE TURNOVER OF INTRATRACHEALLY ADMINISTERED PARTICLES FROM THE LUNGS WAS NEGLIGIBLE THE FIRST TWO DAYS.