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Title:
IMMEDIATE EFFECTS OF 33 TO 180 RAD/MIN COBALT 60 EXPOSURE ON PERFORMANCE AND BLOOD PRESSURE IN MONKEYS
Author(s):
Document Location:
Location - NNSA/NSO Nuclear Testing Archive Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - CIC@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
1976 Sep 01
Declassification Status:
Unknown
Document Pages:
0072
Accession Number:
NV0754814
Document Number(s):
DNA 4147T
Originating Research Org.:
DEFENSE NUCLEAR AGENCY, U.S.
OpenNet Entry Date:
1998 Jun 24
Description/Abstract:
FOUR GROUPS OF MONKEYS RECIEVED 1000 RADS 60 CO AT 33, 50, 75, OR 180 RAD/MIN WHOLEBODY IRRADIATION WHILE PERFORMING A DELAYED MATCHING TO SAMPLE TASK. SYSTEMAIC DOSE RATE EFFECTS WERE OBERVED ON PERFORMANCE AND BLOOD PRESSURE WITHIN THE INTIAL 20 MIN POSTIRRADIATION. THE INCIDENCE AND SEVERITY OF PERFORMANCE DECREMENT INCREASED WITH HIGHER DOSE RATE. THE PERCENTAGE INCIDENCE OF EARLY PD WAS 7, 33, 33, 81 PERCENT RESPECTIVELY FOR THE GROUPS, INCLUDING THOSSE ANIMALS SHOWING EARLY TRANDIENT INCAPACITATION (ETI). THE APPEARENCE OF POSTIRRADIATION HYPOTENSION WAS SYSTEMATICALLY DELAYED AND ITS RATE OF FALL PROLONGED AS DOSE RATE WAS LOWER. THE HYPOTENSION LIKEWISE APPEARED LESS DEEP WITH LOWER DOSE RATE EXPOSURE. BASED ON THE CALCULATED CUMULITIVE DASE ABSORBED AT THE TIME OF APPEARENCE TWO COACTIVE THRESHOLDS WERE PROPOSED TO EXIST: A TOTAL DOSE THRESHOLD OF APPROXIMATELY 300 RADS (MIDBODY MEASUREMENT), AND A DOSE RATE THRESHOLDS OF ABOUT 25 RAD/MIN, FOR THE INDUCTION OF THE EARLY HYPOTENSION-PD/ETI SYNDROME. PD/ETI OCCURED ONLY IN THE PRESENCE OF HYPOTENSION, UNSUALLY FOLLOWING ITS NADIR BY 1 TO 4 MIN. MOREOVER AN INCREASING STRENGTH OF ASSOCIATION BETWEEN DEPTH OF HYPOTENSION AND FREQUENCY OF PD/ETI WAS DEMONSTRATED AS THE HYPOTENSION DECLINED BELOW 50 PERCENT OF BASELINE.


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