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COMBINED EFFECTS OF TOTAL BODY X IRRADIATION AND RADIANT ENERGY THERMAL BURNS. III. OSMOTIC AND MECHANICAL FRAGILITY OF THE ERYTHROCYTE

ALPEN, E L; DAVIS, W M; DAVIS, A K; ALEXANDER, J A

Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV

REPORT

1953 Nov 23

Unknown

0036

NV0754805

USNRDL-419

DEFENSE NUCLEAR AGENCY, U.S.

1998 Jun 24

2017 Dec 22

THE OSMOTOPIC AND MECHANICAL FRAGILITY OF RAT ERYTHROCYTES HAVE BEEN MEASURED DURING THE 30 DAY INTERVAL FOLLOWING SEVERE AND MODERATELY SEVERE BURNS, 100 AND 500 R OF WHOLE BODY IONIZING RADIATION, AND COMBINATIONS OF THE TWO TRAUMATA. IT HAS BEEN FOUND THAT, ALTHOUGH IT IS DIFFICULT TO DEMONSTRATE AND INCREASED FRAGILITY AS EARLY AS 4 HR AFTER SEVER BURNS, THERE IS MOST PROBABLY AND INCREASED RESISTANCE TO OSMOTIC HEMOLYSIS 24 HR LATER AS THE RESULT OF REMOVAL OF THE MOST FRAGLE CELLS. THIS IS A TRANSIENT FINDING AND NORMAL FRAGILITIES ARE FOUND ON THE THIRD DAY. DURING THE RECOVERY PERIOD AN INCREASED RESISTANCE TO OSMOTIC HEMOLUSIS DEVELOPS WHICH IS DISCUSSED AS A POSSIBLE RESULT OF INCREASED RED CELL TURNOVER. IRRADIATION PRODUCES AN INCREASED OSMOTIC RESISTANCE AT THE 500 R DOSSE LEVEL BIT NOT AT 100 R. THIS CHANGE IS CORRELATED WITH REMOVAL OF FRAGILE CELLS AND INCREASED RED CELL TURNOVER. COMBINATION OF THE TRAUMATA BRINGS ABOUT ESSENTIALLY ADDDITIVE RESULTS INSOFAR AS THE OSMOTIC FRAGILITY IS CONCERNED. THE MECHANICAL FRAGILITY WAS FOUND TO BE INCREASED BY LETHAL DOSES OF IONIZING RADIATION AND BY LETHAL COMBINATIONS OF IONIZING RADIATION AND BY LETHAL COMBINATIONS OF IONIZING RADIATION AND BURNS WHEN NETHIER TRAUMAWAS LETHAL ALONE. IT IS THOUGHT THAT THE INCREASED MECHANICAL FRAGILITY IS A SIGN OF IMPENING DEATH IN IRRADIATED ANIMALS EITHER IN THE PRESENCE OR ABSENCE OF OTHER COMPLICATING TRAUMATA.