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COMBINED EFFECTS OF TOTAL BODY X IRRADIATION AND RADIANT ENERGY THERMAL BURNS: STUDY OF BLOOD COAGULATION

DAVIS, W M; LEE, W; ALPEN, E L; DAVIS, A K

Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV

REPORT

1953 Oct 22

Unknown

0031

NV0754803

USNRDL-413

DEFENSE NUCLEAR AGENCY, U.S.

1998 Jun 24

2017 Dec 22

THE EFFECTS OF HIGH INTENSITY RADIANT ENERGY THERMAL BURNS, TOTAL BODY X IRRADIATIION, AND OF COMBINATIONS THERMAL BURNS AND TOTAL BODY X IRRADIATION UPON THE BLOOD COAGULATION MECHINISM HAS BEEN INVESTIGATED IN RATS. TOTAL BODY IRRAADIATION AT A DOSE OF 500 R PRODUCES A RAPIDLY DEVELOPING THROMOCYTOPENIA AND A DEFECTIVE CLOTTING MECHANISM AS MEASURED BY LEE-WHITE AND HEPARIN CLOTTING TIMES. AT A DOSE LEVEL OF 100 R A BRIEF THROMOCYTOSIS IS FOLLOWED BY A TRANSIENT MILD THROMBOCYTOPENIA. THE HIGH INTENSITY RADIENT ENERGY THERMAL BURNS ALONE PRODUCE A BRIEF FALL IN THE LEVEL OF CIRCULATING PLATELETS FOLLOWED BY A SUSTAINED THROMBOCYTOSIS. THE COMBINED EFFECT OF THERMAL BURNS AND TOTAL BODY X IRRAADIATION CONSIST OF THE SAME INTIAL FALL OF PLATELETS SEEN IN BURNS ALONE FOLLOWED BY THE SAME DEGREE OF THROMOCYTOPENIA SEEN IN ANIMALS RECIEVING TOTAL BODY X IRRADIATION AT THE PARTICULAR DOSE GIVEN. HOWEVER THE CLOTTING DEFECT, AS MEASURED BY THE LEE-WHITE AND HEPARIN CLOTTING TIMES, IS NOT AS SEVER IN THE COMBINES INJURY ANIMALS.THE OBSERVED DEFECTIVE COAGULATION MECHANISM FAILS TO ACCOUNT FOR THE REPORTED ENHANCED MORTALITY SEEN IN COMBINES INJURY ANIMALS. HOWEVER, THE THROMBOCYTOPENIA AND DEFECTIVE CLOTTING MECHANISM DOE PERMIT THE RECOGNITION OF CASUALTIES IN WHICH BURNS OR OTHER TRAUMATA ARE COMPLICATED BY THE OCCURENCE OF SUPER IMPOSED TOTAL BODY X IRRADIATION.