Document Details
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Title:
DEOXYRIBONUCLEIC ACID SYNTHESIZING CELLS IN THE BLOOD OF MAN AND DOG EXPOSED TO TOTAL BODY RADIATION ( JOURNAL OF LAB AND CLINICAL MEDICINE, ST. LOUIS, VOL. 57, NO. 5, PP 711-171, MAY 1961 )
Author(s):
ADAMIK, E; ANDREWS, G [OAK RIDGE INSTITUTE OF NUCLEAR STUDIES]; BOND, V P [OAK RIDGE INSTITUTE OF NUCLEAR STUDIES]; CRONKITE, E P [OAK RIDGE INSTITUTE OF NUCLEAR STUDIES]; FLIEDNER, T M [OAK RIDGE INSTITUTE OF NUCLEAR STUDIES]; JOHNSON, M; MENZEL, I; SCHORK, P; WERNER, W
Subject Terms:
HREX
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1961 May 31
Declassification Status:
Never classified
Document Pages:
0007
Accession Number:
NV0704468
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2012 May 14
Description/Abstract:
WITH THE USE OF TRITIATED THYMIDINE, WHICH IS INCORPORATED ONLY INTO NEW DEOXYRIBONUCLEIC ACID, AND THE AUTORADIOGRAPHIC TECHNIQUE, IT HAS BEEN POSSIBLE TO SHOW THAT CELLS CAPABLE OF DEOXYRIBONUCLEIC ACID SYNTHESIS AND THUS, PRESUMABLY, OF DIVISION ARE PRESENT NORMALLY IN THE BLOOD. IN THE PRESENT INVESTIGATIONS THE NUMBER OF THESE CELLS WAS FOLLOWED SERIALLY IN FIVE MEN EXPOSED TO LARGE DOSES OF WHOLE BODY RADIATION IN AN ACCIDENT INVOLVING FISSIONABLE MATERIAL AT THE OAK RIDGE NATIONAL LABORATORY. SIMILAR STUDIES WERE PERFORMED ON IRRADIATED DOGS TO CONFIRM AND EXTEND THESE OBSERVATIONS. FOLLOWING EXPOSURE THE NUMBER OF CELLS FALLS DRASTICALLY WITHIN HOURS. THE VALUES THEN RISE GRADUALLY, TO ATTAIN LEVELS EXCEEDING NORMAL APPROXIMATELY TEN DAYS AFTER EXPOSURE OF THE HUMAN. A SECOND PEAK EXCEEDING NORMAL LEVELS IS NOTED AT APPROXIMATELY FORTY DAYS. THE CELLS ARE ALL OF THE LARGE MONONUCLEAR TYPE. THE POSSIBLE FATE AND FUNCTION OF THESE CELLS ARE DISCUSSED.