Document Details
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(432 K)
Title:
TOTAL BODY IRRADIATION AND HUMAN CHROMOSOMES. II CYTOGENETIC STUDIES OF THE CULTURED BONE MARROW CELLS SEVEN YEARS AFTER TOTAL BODY IRRADIATION ( MEDICAL DIVISION, OAK RIDGE ASSOC. UNIVERSITIES )
Author(s):
KONGOO, G [OAK RIDGE ASSOCIATED UNIVERSITIES]
Subject Terms:
HREX
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
Declassification Status:
Never classified
Document Pages:
0007
Accession Number:
NV0704449
Originating Research Org.:
OAK RIDGE ASSOCIATED UNIVERSITIES
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2012 May 14
Description/Abstract:
CHROMOSOMAL BREAKS AND CELLS WITH ABNORMAL CHROMOSOMES WERE FOUND IN THE CULTURES OF BONE MARROW OBTAINED FROM SIX PATIENTS WHO HAD BEEN EXPOSED TO TOTAL BODY IRRADIATION SEVEN YEARS PREVIOUSLY. THE FREQUENCIES OF CHROMOSOMAL BREAKS AND THE ABNORMAL CELLS ARE HIGHER THAN THE NORMALS. HOWEVER, THE FREQUENCIES OF THESE ABNORMALITIES ARE SIMILAR TO THOSE FOUND IN THESE PATIENTS' CULTURED PERIPHERAL LEUKOCYTES REPORTED PREVIOUSLY. DIFFERENT STEM-CELL LINES WITH DIFFERENT MARKER CHROMOSOMES WERE FOUND IN THESE PATIENTS, SPECIFICALLY A SMALLER G AND AN ABNORMALLY LARGE ACROCENTRIC CHROMOSOME. STEM-CELL LINES WITH THE ABNORMAL MORPHOLOGIC CHROMOSOMES HAVE BEEN SEEN IN PATIENTS WITH LEUKEMIA OR CANCER, BUT NONE OF THE PRESENT PATIENTS HAD THESE DISEASES. THUS, IT SEEMS IMPORTANT TO DETERMINE WHY CYTOLOGICALLY DETECTABLE ABNORMAL STEM-CELL LINES DEVELOP INTO LEUKEMIA OR CANCER IN SOME PEOPLE BUT NOT OTHERS.