Document Details


PURL
View Full Text
(359 K)
Title:
PREMATURE MENOPAUSE IN XO/XX/XXX/XXXXX MOSAICISM ( AMERICAN JOURNAL OF OBST. & GYNEC., 01-10-67 )
Author(s):
GORDON, D L [UNIVERSITY OF WASHINGTON, SEATTLE]; PAULSEN, C A [UNIVERSITY OF WASHINGTON, SEATTLE]
Subject Terms:
HREX
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1967 Dec 31
Declassification Status:
Never classified
Document Pages:
0006
Accession Number:
NV0703771
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2012 May 14
Description/Abstract:
PREMATURE MENOPAUSE HAS BEEN DEFINED AS THE FAILURE OF NORMAL OVARIAN FUNCTION PRIOR TO AGE 40 IN THE PRESENCE OF LOW URINARY ESTROGEN LEVELS, ELEVATED URINARY GONADOTROPIN TITERS, AND VASOMOTOR SYMPTOMS. THE POSSIBILITY THAT SEX CHROMOSOMAL ABNORMALITIES MAY BE ONE OF THE FACTORS IN THE PATHOGENESIS OF THIS ENTITY WAS RAISED BY THE ACCOUNT WHICH DOCUMENTED THE FINDING OF AN XXX CHROMOSOMAL PATTERN IN A WOMAN WITH PREMATURE MENOPAUSE. THIS REPORT DESCRIBES A PATIENT WITH PREMATURE MENOPAUSE WHO WAS FOUND TO HAVE AN UNUSUAL FORM OF SEX CHROMOSOMAL MOSAICISM. DATA SUGGEST THE PRESENCE OF XO/XX/XXX/XXXXX MOSAICISM. SEVERAL POSSIBILITIES EXIST TO EXPLAIN THE CYTOLOGIC EVENTS THAT RESULTED IN THIS TYPE OF SEX CHROMOSOMAL MOSAICISM. THE SIMPLEST MECHANISM TAKES INTO ACCOUNT TWO SEPARATE EPISODES OF NONDISJUNCTION IN THE POSTZYGOTIC PERIOD, SO THAT THE END RESULT IS FOUR STEM-CELL LINES (XO/XX/XXX/XXXX). THIS IS THE FIRST REPORTED CASE OF THIS TYPE.


<< Return to Search Results