Document Details

(55 K)

STUDIES OF HUMAN SUBJECTS ABSTRACT ( COMPANION TO 703712-703714, 703716 )

BASSETT, S H; FRANKEL, A

HREX; ABSTRACT; DOSE; HUMAN SUBJECTS; INTRAVENOUSLY; ISOTOPES; STUDIES; URANIUM

Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV

MISCELLANEOUS

Declassified

0001

NV0703715

1994 Aug 27

2017 Dec 15

STUDIES ON HUMAN SUBJECTS - THIS IS ABSTRACT FROM BOOK TITLED THE EXCRETION OF HEXAVALENT URANIUM FOLLOWING INTRAVENOUS ADMINISTRATION. THE STUDIES EMPLOYING URANIUM ENRICHED IN THE ISOTOPES U-234 AND U-235 HAVE BEEN CARRIED OUT IN SIX HUMAN SUBJECTS; FOUR MALES AND TWO FEMALES. THE URANIUM WAS GIVEN INTRAVENOUSLY IN THE HEXAVALENT STATE AS URENAL NITRATE IN AMOUNTS RANGING FROM 6 MICROGRAMS TO 70 MICROGRAMS PER KILOGRAM OF BODY WEIGHT. EACH INDIVIDUAL OF THE SERIES RECEIVED A SINGLE INJECTION OF THE METAL EXCEPT FOR SUBJECT 6 WHO WAS GIVEN TWO WIDELY SPACED DOSES. THE FIRST OF THESE WAS WHEN HIS CONDITION WAS NORMAL AND THE SECOND AFTER AN ACIDOSIS HAD BEEN PRODUCED BY INGESTION OF AMMONIUM CHLORIDE. RENAL FUNCTION THAT INCLUDED URINARY CATALASO, PROTEIN AMINO N TO CREATININE N RATIO, AND CLEARANCES OF MANNITEL AND P - AMINOHIPPURATE WERE DONE BEFORE AND AFTER ADMINISTRATION OF URANIUM. ONLY AT THE 70 MICROGRAM PER KILOGRAM LEVEL IN SUBJECT 6 WAS THERE A SLIGHT RISE IN URINARY CATALASO AND PROTEIN SUGGESTING THAT TOLERANCE HAD BEEN REACHED. ALL OTHER TESTS WERE NEGATIVE. THE EXCRETION OF URANIUM WAS MAINLY IN THE URINE, WHERE FROM 70 TO 85 PER CENT OF THE ADMINISTERED DOSE APPEARED IN THE FIRST TWENTY-FOUR HOURS. URINE OF THE SECOND TWENTY-FOURS CONTAINED ABOUT 4 PER CENT, AND IN THE THIRD 24-HOUR URINE, 1.5 PER CENT OF THE ADMINISTERED DOSE. DETECTABLE AMOUNTS WERE EXCRETED FOR AT LEAST TWO WEEKS. IT IS SURMISED THAT THIS LATE EXCRETION REPRESENTED URANIUM ORIGINALLY STORED IN THE BONES. NEGLIGIBLE AMOUNTS OF URANIUM WERE FOUND IN THE FECES.