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Title:
REPORT: DISTRIBUTION AND EXCRETION OF PLUTONIUM ADMINISTERED INTRAVENOUSLY TO MAN ( JOINT REPORT, LOS ALAMOS SCIENTIFIC LABORATORY OF UNIVERSITY OF CA AND AEC PROJECT OF THE UNIVERSITY OF ROCHESTER
Author(s):
BASSETT, S H [AEC-ATOMIC ENERGY COMMISSION, THE U.S.]; CARTER, R E [LOS ALAMOS SCIENTIFIC LABORATORY]; HARRIS, P S [AEC-ATOMIC ENERGY COMMISSION, THE U.S.]; LANGHAM, W H [LOS ALAMOS SCIENTIFIC LABORATORY]
Subject Terms:
HREX; EXCRETION; INTRAVENOUS; PLUTONIUM
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
REPORT
Publication Date:
1950 Sep 20
Declassification Status:
Never classified
Document Pages:
0040
Accession Number:
NV0703587
Originating Research Org.:
LOS ALAMOS SCIENTIFIC LABORATORY
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2012 May 14
Description/Abstract:
JOINT REPORT FROM LOS ALAMOS SCIENTIFIC LABORATORY OF THE UNIVERSITY OF CALIFORNIA AND THE ATOMIC ENERGY PROJECT OF THE UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY. THE REPORT COVERS A COOPERATIVE RESEARCH PROJECT INITIATED UNDER THE SUPERVISION OF THE MANHATTAN ENGINEER DISTRICT AND COMPLETED UNDER CONTRACT FOR THE ATOMIC ENERGY COMMISSION. (SEPTEMBER 20, 1950) DISTRIBUTION AND EXCRETION OF PLUTONIUM ADMINISTERED INTRAVENOUSLY TO MAN. THE DISTRIBUTION AND EXCRETION OF PLUTONIUM ADMINISTERED INTRAVENOUSLY TO MAN HAS BEEN STUDIED. THE DATA FROM TWELVE SUBJECTS HAVE BEEN CORRELATED WITH SIMILAR DATA COLLECTED BY OTHER INVESTIGATORS, MAKING A TOTAL OF 16 CASES CONSIDERED. THE DATA HAVE BEEN SUPPLEMENTED FURTHER WITH OBSERVATIONS MADE ON 3 LOS ALAMOS LABORATORY PERSONNEL WHO ABSORBED MEASURABLE AMOUNTS OF PLUTONIUM IN THE COURSE OF THEIR WORK. THE RESULTS OF THESE STUDIES IS SUMMARIZED AS FOLLOWS: INTRAVENOUS INJECTION OF A SINGLE DOSE OF 5 TO 100 UG OF PLUTONIUM IS WITHOUT ACUTE SUBJECTIVE OR OBJECTIVE EFFECTS. ANALYSIS OF TISSUE FOLLOWING PLUTONIUM INJECTION SHOWED LITTLE DIFFERENCE IN THE MODE OF DEPOSITION OF PLUTONIUM IN MAN AND IN LABORATORY ANIMALS. CONCENTRATION OF PLUTONIUM IN THE BLOOD FOLLOWING INJECTION DROPS VERY RAPIDLY. URINARY EXCRETION OF INTRAVENOUSLY ADMINISTERED PLUTONIUM WAS NOT EXPONENTIAL. EXCRETION OF PLUTONIUM IN FECES WAS NOT EXPONENTIAL.