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THE EXCRETION OF HEXAVALENT URANIUM FOLLOWING INTRAVENOUS ADMINISTRATION, UNIVERSITY OF ROCHESTER HEALTH AND BIOLOGY PROJECT REPORT ( PLUTONIUM INJECTION EXPERIMENTS )

BASSETT, S H [UNIVERSITY OF ROCHESTER]; CODARO, N [UNIVERSITY OF ROCHESTER]; CUSSON, K [UNIVERSITY OF ROCHESTER]; FRENKEL, A [UNIVERSITY OF ROCHESTER]; VANALSTINE, A [UNIVERSITY OF ROCHESTER]; WATERHOUSE, C [UNIVERSITY OF ROCHESTER]

HREX; EXCRETION; HEXAVALENT; STUDIES; URANIUM

Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV

REPORT

Never classified

0055

NV0703575

1994 Aug 27

2012 May 14

PLUTONIUM INJECTION STUDIES - A REPORT- THE EXCRETION OF HEXAVALENT URANIUM FOLLOWING INTRAVENOUS ADMINISTRATION BY SAMUEL H. BASSETT, ALBERT FRENKEL, NATHAN CEDARS, HELEN VANALSTINE, CHRISTINE WATERHOUSE, AND KATHERINE CUSSON. STUDIES EMPLOYING URANIUM ENRICHED IN THE ISOTOPES URANIUM 234, URANIUM 235 HAVE BEEN CARRIED OUT IN SIX HUMAN SUBJECTS; FOUR MALES AND TWO FEMALES. THE URANIUM WAS GIVEN INTRAVENOUSLY IN THE HEXAVALENT STATE AS URENYL NITRATE IN AMOUNTS RANGING FROM 6 MICROGRAMS TO 70 MICROGRAMS PER KILOGRAM OF BODY WEIGHT. EACH INDIVIDUAL IN THE SERIES RECEIVED A SINGLE INJECTION OF THE METAL EXCEPT FOR SUBJECT 6 WHO WAS GIVEN 2 WIDELY SPACED DOSES. THE FIRST OF THESE WAS WHEN HIS CONDITION WAS NORMAL AND THE SECOND AFTER AN ACIDOSIS HAD BEEN PRODUCED BY INGESTION OF AMMONIUM CHLORIDE. RENAL FUNCTION TESTS INCLUDING URINARY CATALASO, PROTEIN, AMINO N TO CREATININE N RATIO, AND CLEARANCES OF MANNITOL AND P - AMINOHIPPURATE WERE DONE BEFORE AND AFTER ADMINISTRATION OF URANIUM. ONLY AT THE 70 MICROGRAM PER KILOGRAM LEVEL IN SUBJECT 6 WAS THERE A SLIGHT RISE IN URINARY CATALASO AND PROTEIN SUGGESTING THAT TOLERANCE HAD BEEN REACHED. ALL OTHER TESTS WERE NEGATIVE. THE EXCRETION OF URANIUM WAS MAINLY IN THE URINE, WHERE FROM 70 TO 85 PERCENT OF THE ADMINISTERED DOSE APPEARED IN THE FIRST 24 HOURS. URINE OF THE SECOND 24 HOURS CONTAINED ABOUT 4 PERCENT AND THE THIRD 24 HOUR URINE, 1.5 PERCENT OF THE ADMINISTERED DOSE. DETECTABLE AMOUNTS WERE EXCRETED FOR AT LEAST TW0 WEEKS. IT IS SURMISED THAT THIS LATE EXCRETION REPRESENTED URANIUM ORIGINALLY STORED IN THE BONES. NEGLIGIBLE AMOUNTS OF URANIUM WERE FOUND IN THE FECES.