Document Details
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Title:
JOURNAL ARTICLE, PLUTONIUM IN MAN: A NEW LOOK AT THE OLD DATA ( PLUTONIUM INJECTION EXPERIMENT )
Author(s):
DURBIN, P W [LAWRENCE LIVERMORE NATIONAL LABORATORY]
Subject Terms:
HREX; ABSTRACT; BLOOD; EXCRETION; EXPERIMENTAL DATA; INJECTION; LIVER; PLUTONIUM; PLUTONIUM INJECTION EXPERIMENT; TISSUES
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
Declassification Status:
Never classified
Document Pages:
0002
Accession Number:
NV0703538
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2012 May 14
Description/Abstract:
"PLUTONIUM IN MAN: A NEW LOOK AT THE OLD DATA." AN ABSTRACT ON THE ARTICLE READS, "IN ORDER TO DETERMINE THE RELATIONSHIPS BETWEEN URINARY PLUTONIUM EXCRETION AND BODY PLUTONIUM CONTENT, 18 PERSONS (15 OVER THE AGE OF 45) WERE INJECTED IN 1945 AND 1946 WITH TRACER DOSES OF 239-PU. THE ORIGINALDATA HAVE BEEN CRITICALLY REVIEWED AND RE-ANALYZED. A FEW DAYS AFTER INJECTION, HUMAN SOFT TISSUES (OTHER THAN BLOOD AND LIVER) CONTAINED AS MUCH AS 20% OF THE PU DOSE. FIVE TO 15 MONTHS AFTER INJECTION THE AVERAGE LIVER PU CONTENT WAS 31% OF THE DOSE FOR THREE CASES WITH PRESUMABLY NORMAL LIVER FUNCTION. FOUR TO 457 DAYS AFTER INJECTION MEAN TOTAL SKELETAL PU WAS 49% FOR THE SEVEN CASES JUDGED TO HAVE MOST NEARLY NORMAL LIVERS AND SKELETONS. PLUTONIUM IS TRANSPORTED IN BLOOD COMBINED WITH TRANSFERRIN, THE IRON-TRANSPORT PROTEIN, AND IS STORED IN THE LIVER IN ASSOCIATION WITH STORED IRON. AFTER BEING BOUND TO TRANSFERRIN, PLUTONIUM PARTIALLY TRACES THE BEHAVIOR OF THE CARRIER PROTEIN. THE EARLY PHASES OF PLUTONIUM TRANSPORT WHICH ARE APPARENTLY ASSOCIATED WITH EXTRA-CELLULAR FLUID MISSING, WERE PROLONGED IN INDIVIDUALS WITH IMPAIRED CIRCULATION."