Document Details
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(841 K)
Title:
A STUDY IN DOGS OF METHODS SUITABLE FOR ESTIMATING RATE OF MYOCARDIAL UPTAKE OF RUBIDIUM-86 IN MAN & THE EFFECT OF L-NOREPINEPHRINE & PITRESSINR ON RUBIDIUM-86 UPTAKE ( CONTINUED IN ABSTRACT )
Author(s):
BURCH, G E; BURCH, G E [TULANE UNIVERSITY]; CRONVICH, J A; GORDON, W H; LOVE, W D; MILNOR, J P; OVERMAN, W J; REASER, P B; THREEFOOT, S A
Subject Terms:
HREX; RUBIDIUM 86
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1957 Mar 31
Declassification Status:
Never classified
Document Pages:
0012
Accession Number:
NV0702743
Originating Research Org.:
REYNOLDS ELECTRICAL AND ENGINEERING COMPANY
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2012 May 14
Description/Abstract:
(CONT'D FROM TITLE) (JOURNAL OF CLINICAL INVESTIGATION, VOL. 36, A MARCH 1957, PGS 468-678) (PARTIAL). THE MYOCARDIUM IN MAN. IN THE EXPERIMENTAL ANIMAL, IT WAS POSSIBLE TO COMPARE ESTIMATES THAT WERE BASED ON EXTERNAL MEASUREMENTS OF THE TYPE POSSIBLE IN MAN WITH THE ACTUAL MYOCARDIAL UPTAKE OF RUBIDIUM-86 DETERMINED BY DIRECT ANALYSIS OF THE HEART AFTER SACRIFICE. AS A PARTIAL TEST OF THE RELATIONSHIP BETWEEN CORONARY BLOOD FLOW AND RUBIDIUM-86 UPTAKE RATE IN THE HEART, 1-NOREPINEPHRINE OR PITRESSIN WERE ADMINISTERED INTRAVENOUSLY TO SEVERAL DOGS BECAUSE OF THE KNOWN EFFECTS OF THESE DRUGS ON THE CORONARY BLOOD FLOW. CHANGES IN PLASMA RUBIDIUM-86 CLEARANCE WERE IN THE DIRECTION EXPECTED FROM THE KNOWN EFFECTS OF THESE DRUGS ON CORONARY BLOOD FLOW. THE ABILITY TO DETECT SUCH CHANGES WITH A REASONABLE DEGREE OF ACCURACY IN DOGS BY EXTERNAL MONITORING OVER THE HEART SUPPORTS A TRIAL OF THESE PROCEDURES IN MAN.