Document Details

PURL

(457 K)

Title:

TRACER STUDIES OF THE URINARY EXCRETION OF RADIOACTIVE MERCURY FOLLOWING ORAL ADMINISTRATION OF A MERCURIAL DIURETIC ( CIRCULATION ( U.S. ) ( CIRCA ), VOL. 1, APRIL 1950, PGS. 496-501 ) (PARTIAL)

Author(s):

BURCH, G E [TULANE UNIVERSITY]; GORDON, W H; OVERMAN, W J

Subject Terms:

HREX; MERCURY

Document Location:

Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV

Document Type:

JOURNAL ARTICLE

Publication Date:

1950 Apr 30

Declassification Status:

Never classified

Document Pages:

0007

Accession Number:

NV0702741

Originating Research Org.:

REYNOLDS ELECTRICAL AND ENGINEERING COMPANY

OpenNet Entry Date:

1994 Aug 27

OpenNet Modified Date:

2012 May 14

Description/Abstract:

BY MEANS OF TRACER METHODS THE ABSORPTION, BLOOD CONCENTRATION AND URINARY EXCRETION OF MERCURY FOLLOWING ORAL ADMINISTRATION OF STANDARDIZED SINGLE DOSES OF PLAIN AND ENTERIC-COATED CAPSULES OF A MERCURIAL DIURETIC WERE STUDIED IN 22 CONTROL SUBJECTS AND IN 5 SUBJECTS WITH CHRONIC CONGESTIVE HEART FAILURE. ENTERIC COATING OF THE CAPSULES RESULTED IN THE LOWEST BLOOD CONCENTRATIONS AND IN THE POOREST URINARY EXCRETION OF MERCURY, WHICH INDICATES THAT MAXIMUM ABSORPTION OCCURRED HIGH IN THE GASTROINTESTINAL TRACT. THE OBSERVATIONS OF POOR ABSORPTION, LOW BLOOD CONCENTRATION, AND LOW URINARY EXCRETION OF MERCURY FOLLOWING ORAL ADMINISTRATION OF THIS MERCURIAL DIURETIC PRECLUDES ITS GENERAL USE IN THE TREATMENT OF CHRONIC CONGESTIVE HEART FAILURE.

<< Return to Search Results