Document Details
PURL
(540 K)
Title:
EFFECTS OF RADIATION ON THE HUMAN HEART: AN ELECTRON MICROSCOPIC STUDY ( ARCHIVES OF INTERNAL MEDICINE, VOL. 121, MARCH 1968, PGS. 230-234 ) (PARTIAL)
Author(s):
BURCH, G E [TULANE UNIVERSITY]; COLCOLOUGH, H L; MILLER, G C; SOHAL, R S [TULANE UNIVERSITY]; SUN, S
Subject Terms:
HREX
Document Location:
Location - DOE/NNSA NUCLEAR TESTING ARCHIVE Address - P.O. Box 98521 City - Las Vegas State - NV Zip - 89193-8521 Phone - (702)794-5106 Fax - (702)862-4240 Email - NTA@NV.DOE.GOV
Document Type:
JOURNAL ARTICLE
Publication Date:
1968 Dec 31
Declassification Status:
Never classified
Document Pages:
0005
Accession Number:
NV0702738
Originating Research Org.:
REYNOLDS ELECTRICAL AND ENGINEERING COMPANY
OpenNet Entry Date:
1994 Aug 27
OpenNet Modified Date:
2012 May 14
Description/Abstract:
AN ULTRASTRUCTURAL STUDY OF THE HEART OF A PATIENT WHO DIED OF MYOCARDIAL DISEASE WITH CONGESTIVE HEART FAILURE DUE TO X-RADIATION FOLLOWING RADIOLOGICAL TREATMENT FOR CARCINOMA OF THYROID WAS MADE. THE HEART TISSUE WAS OBTAINED FOR STUDY IN 10 PERCENT BUFFERED NEUTRAL FORMALDEHYDE. FOR HISTOLOGY, SOME OF THE TISSUE WAS PROCESSED BY CONVENTIONAL METHODS FOR HEMATOXYLIN AND EOSIN STAINING. FOR ELECTRON MICROSCOPY, SMALL TISSUE BLOCKS WERE WASHED IN PHOSPHATE BUFFER AND REFIXED IN 1 PERCENT OSMIUM TETROXIDE FOR 90 MINUTES. THE LIGHT MICROSCOPIC STUDY INDICATED MYOCARDIAL DAMAGE CHARACTERISTIC FOR POSTIRRADIATION EFFECT. THE PRESENT STUDY INDICATES THAT AFTER IRRADIATION SIGNIFICANT CHANGES OCCUR AT THE SUBCELLULAR LEVEL IN THE MYOCARDIUM OF MAN. IRRADIATION OF THE HEART SEEMS TO PRODUCE EXTENSIVE DISORGANIZATION OF MITOCHONDRIA, MYOFIBRILS, NUCLEUS, AND SARCOLEMMA.